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• Clinical Article •
Evaluation of rest-state fMRI in patients with lumbar disc herniation based on ALFF
XUE Qin  TU Jianchun  DAI Dechun  LÜ Ying  XU Ting 

Cite this article as: XUE Q, TU J C, DAI D C, et al. Evaluation of rest-state fMRI in patients with lumbar disc herniation based on ALFF[J]. Chin J Magn Reson Imaging, 2024, 15(8): 78-83. DOI:10.12015/issn.1674-8034.2024.08.012.


[Abstract] Objective To analyze the changes in resting-state functional magnetic resonance imaging (rs-fMRI) in patients with lumbar disc herniation (LDH) and explore potential neuroimaging mechanisms.Materials and Methods A total of 24 LDH patients were prospectively included, along with 30 chronic nonspecific low back pain patients (CNLBP) and 27 healthy controls (HC) as the control group. First, the LDH group and CNLBP group underwent Visual Analog Scale (VAS), Oswestry Disability Index (ODI), and Japanese Orthopedic Association (JOA) assessments. Then, all three groups underwent rs-fMRI scanning, and the differences in amplitude of low-frequency fluctuation (ALFF) values among the three groups were compared. Finally, the ALFF values of the brain regions differed between the LDH group and CNLBP group were extracted and correlated with the clinical scales.Results The clinical scale evaluation results showed that there was no difference in VAS scores between the LDH group and CNLBP group, but there were differences in ODI and JOA scores, indicating that LDH patients had more severe lumbar dysfunction. The brain regions with altered ALFF values among the three groups were bilateral calcarine/cuneus cortex, left thalamus (GRF correction, P<0.005 at voxel level, P<0.01 at cluster level). Compared with the HC group, the LDH group had decreased ALFF values in the bilateral calcarine/cuneus cortex, and increased ALFF values in the left thalamus; the CNLBP group had decreased ALFF values in the bilateral calcarine/cuneus cortex but no increased ALFF values. Compared with the CNLBP group, the LDH group had increased ALFF values in the left thalamus but no decreased ALFF values. No correlation was found between the ALFF values of the brain regions differed between the LDH group and CNLBP group and the clinical scales.Conclusions Patients with LDH have both shared and unique pain central regulatory mechanisms with CNLBP patients.The change of left thalamic functional activity may be an important characteristic of the LDH central mechanism.
[Keywords] lumbar disc herniation；chronic nonspecific low back pain；resting-state functional magnetic resonance imaging；magnetic resonance imaging；amplitude of low-frequency fluctuation

XUE Qin1   TU Jianchun1   DAI Dechun2   LÜ Ying2   XU Ting1*  

1 Department of Radiology, Kunshan Traditional Chinese Medicine Hospital, Suzhou 215300, China

2 Department of Acupuncture Massage and Rehabilitation, Kunshan Hospital of Traditional Chinese Medicine, Suzhou 215300, China

Corresponding author: XU T, E-mail: xut0618@163.com

Conflicts of interest   None.

Received  2024-02-28
Accepted  2024-08-02
DOI: 10.12015/issn.1674-8034.2024.08.012
Cite this article as: XUE Q, TU J C, DAI D C, et al. Evaluation of rest-state fMRI in patients with lumbar disc herniation based on ALFF[J]. Chin J Magn Reson Imaging, 2024, 15(8): 78-83. DOI:10.12015/issn.1674-8034.2024.08.012.

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