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Evaluation of glymphatic system activity and disease state by diffusion tensor image analysis along the perivascular space index in children with benign Rolandic epilepsy
GAO Lu  ZHANG Na  WANG Xiaoyu  FENG Yuying  LI Xianjun  BIAN Yitong  LIU Zhe  YANG Jian 

Cite this article as: GAO L, ZHANG N, WANG X Y, et al. Evaluation of glymphatic system activity and disease state by diffusion tensor image analysis along the perivascular space index in children with benign Rolandic epilepsy[J]. Chin J Magn Reson Imaging, 2024, 15(9): 6-10. DOI:10.12015/issn.1674-8034.2024.09.002.


[Abstract] Objective To investigate the value of diffusion tensor image analysis along the perivascular space index (DTI-ALPS index) on glymphatic system (GS) activity and disease state in children with benign Rolandic epilepsy (RE).Materials and Methods Twenty patients aged 6-12 years with RE and 20 children matched in gender and age underwent conventional MRI and diffusion tensor imaging (DTI). Quantitative analysis DTI-ALPS index between two groups. Meanwhile, correlation of DTI-ALPS index with seizure duration, epileptic frequency and cognitive development were respectively explored via Pearson's coefficient (r).Results Compared with control group, DTI-ALPS index was higher in control group than patient group (RE: 1.41±0.20, Control: 1.56±0.16; t=-2.620, P=0.013). DTI-ALPS index positively correlated with age (r_patient=0.483, P=0.002; r_control=0.534, P<0.001), full intelligence quotient (FIQ) and verbal intelligence quotient (VIQ) (r_FIQ=0.523, P=0.014; r_VIQ=0.563, P=0.001). However, DTI-ALPS index gradually decreased with seizure duration and epileptic frequency (r_seizure duration=-0.743, P<0.001; r_epileptic frequency=-0.460, P=0.044). There was no significant associations between DTI-ALPS index and practical intelligence quotient (PIQ).Conclusions DTI-ALPS index can be used to evaluated impairment of the GS in RE, which has a good prospect for exploring the state of RE.
[Keywords] benign Rolandic epilepsy；glymphatic system；magnetic resonance imaging；diffusion tensor imaging, perivascular space

GAO Lu   ZHANG Na   WANG Xiaoyu   FENG Yuying   LI Xianjun   BIAN Yitong   LIU Zhe   YANG Jian*  

Department of Radiology, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, China

Corresponding author: YANG J, E-mail: yj1118@xjtu.edu.cn

Conflicts of interest   None.

Received  2023-11-29
Accepted  2024-02-26
DOI: 10.12015/issn.1674-8034.2024.09.002
Cite this article as: GAO L, ZHANG N, WANG X Y, et al. Evaluation of glymphatic system activity and disease state by diffusion tensor image analysis along the perivascular space index in children with benign Rolandic epilepsy[J]. Chin J Magn Reson Imaging, 2024, 15(9): 6-10. DOI:10.12015/issn.1674-8034.2024.09.002.

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