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• Clinical Article •
Value of intravoxel incoherent motion diffusion in the clinical diagnosis of Alzheimer's disease
XING Peiqiu  CHEN Qiuyan  ZHENG Tianxiu  ZHENG Yushan  QIU Yanhua  WEI Dingtai 

Cite this article as: XING P Q, CHEN Q Y, ZHENG T X, et al. Value of intravoxel incoherent motion diffusion in the clinical diagnosis of Alzheimer's disease[J]. Chin J Magn Reson Imaging, 2024, 15(9): 33-40. DOI:10.12015/issn.1674-8034.2024.09.007.


[Abstract] Objective To investigate the application value of intravoxel incoherent motion (IVIM) in the clinical diagnosis of Alzheimer's disease (AD).Materials and Methods A total of 60 subjects were included in this study, including 23 in the AD group, 22 in the mild cognitive impairment (MCI) group and 15 in the normal control (NC) group. The standard apparent diffusion coefficient (ADCst) and IVIM measures IVIM measures of hippocampal head, hippocampus and hippocampal tail among the three groups were compared for statistical significance, and the correlation between clinically relevant cognitive scores and MRI measures was analyzed.Results Compared with NC group, ADCst in hippocampus and hippocampus of MCI group and AD group showed an increased trend, but only the right hippocampal head and bilateral hippocampus of AD group and the left hippocampus of MCI group had statistical differences (P<0.05). The increase of IVIM-D value in MCI group and AD group was more obvious. Compared with NC group, the statistical difference was found in the bilateral hippocampus of MCI group (P<0.05), bilateral hippocampal head of AD group (P≤0.001) and bilateral hippocampus of AD group (P<0.001). The IVIM-D values of both hippocampal head and hippocampus in AD group were higher than those in MCI group, with statistical difference (P<0.01). There was no statistically significant difference in the hippocampal tail among the three groups (P>0.05).The ADCst values of the right hippocampus and the IVIM-D values of the bilateral hippocampal head and hippocampus were moderately correlated with the total score of MMSE (0.4<|r|<0.7), while the ADCst values of the bilateral hippocampal head and the left hippocampus were weakly correlated with the total score of MMSE (0.2<|r|<0.4). Further use the receiver operating characteristic, ROC curve analysis showed that ADCst values of bilateral hippocampal head and right hippocampus and IVIM-D values of bilateral hippocampal head and hippocampus had certain diagnostic efficiency in distinguishing AD (AUC=0.664-0.866, P<0.05). The AUC of IVIM-D in the right hippocampus was the largest (P<0.001). By combining the IVIM-D values of bilateral hippocampal head and hippocampus to establish a diagnostic prediction model, the AUC could be further improved to 0.961. The prediction model based on IVIM-D values shows a closer fit to the standard curve in actual observations and demonstrates a higher net yield.Conclusions IVIM imaging is a promising imaging method to distinguish AD from NC, and the IVIM-ADC of hippocampal head and hippocampus may be effective biomarkers to diagnose MCI and AD.
[Keywords] Alzheimer's disease, mild cognitive impairment, intravoxel incoherent motion diffusion, magnetic resonance imaging；hippocampus

XING Peiqiu1, 2   CHEN Qiuyan1, 2   ZHENG Tianxiu1, 2   ZHENG Yushan1, 2   QIU Yanhua1, 3   WEI Dingtai1, 2*  

1 Department of Imaging, Ningde Hospital Affiliated to Ningde Normal University, Ningde 352100, China

2 Functional and Molecular Imaging Laboratory for Cerebral Vascular Diseases, Ningde Hospital Affiliated to Ningde Normal University, Ningde 352100, China

3 Department of Imaging, Zhangzhou Affiliated Hospital of Fujian Medical University, Zhangzhou 363000, China

Corresponding author: WEI D T, E-mail: wdtai83@163.com

Conflicts of interest   None.

Received  2024-05-12
Accepted  2024-09-10
DOI: 10.12015/issn.1674-8034.2024.09.007
Cite this article as: XING P Q, CHEN Q Y, ZHENG T X, et al. Value of intravoxel incoherent motion diffusion in the clinical diagnosis of Alzheimer's disease[J]. Chin J Magn Reson Imaging, 2024, 15(9): 33-40. DOI:10.12015/issn.1674-8034.2024.09.007.

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