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• Clinical Article •
The effect of methadone maintenance treatment on degree centrality in heroin dependent patients: a resting state fMRI study
CHEN Jiajie  WANG Zhidong  JIN Long  LI Wei  LI Qiang  Wang Wei  DAI Xiaofeng 

Cite this article as: CHEN J J, WANG Z D, JIN L, et al. The effect of methadone maintenance treatment on degree centrality in heroin dependent patients: a resting state fMRI study[J]. Chin J Magn Reson Imaging, 2024, 15(9): 47-52. DOI:10.12015/issn.1674-8034.2024.09.009.


[Abstract] Objective To explore the effect of methadone maintenance treatment (MMT) on the degree centrality (DC) of topological characteristics of heroin dependence (HD) and its correlation with psychological behavior.Materials and Methods A retrospective analysis was conducted on forty-one HD patients undergoing MMT program were recruited at Methadone Clinic in Baqiao District of Xi'an City from January 2016 to December 2017. The resting state functional magnetic resonance imaging (fMRI) data were collected. Protracted withdrawal symptoms and craving scores were assessed. The patients were followed longitudinally for one year. DC analysis was performed on the image data, and the paired sample t test was used for longitudinal comparison, and the correlation between different brain regions and psychological indicators was analyzed.Results There was significant difference in the scores of protracted withdrawal symptoms of HD patients after MMT for one year (Z=3.004, P=0.003), but there was no significant difference in the scores of cravings (Z=0.872, P=0.383). Compared with baseline, one year after MMT, the DC of the bilateral thalamus, caudate nucleus, putamen, and left pallidum decreased in HD patients (Gaussian random field correction, voxel level P<0.001, cluster level P<0.01, clusters sizes>95). The DC value of the right lingual gyrus and calcarine gyrus increased after the same correction method. The DC value of bilateral caudate nucleus and left pallidum was negatively correlated with withdrawal symptoms (r=-0.417, P=0.030; r=-0.392, P=0.043; r=-0.383, P=0.049), and the change of DC value of bilateral putamen nucleus and left pallidum was positively correlated with the change of craving (r=0.410, P=0.008; r=0.332, P=0.034; r=0.395, P=0.011).Conclusions Methadone may regulate the protracted withdrawal symptoms and psychological craving of HD patients by reducing the centrality of striatum in addiction reward brain network. It may inhibit impulsiveness and enhance the activity of the visual core brain area. These could provide imaging evidence for the neural mechanism of methadone in the treatment of HD patients.
[Keywords] heroin dependence；methadone；degree centrality；corpus striatum；reward；craving；magnetic resonance imaging

CHEN Jiajie1   WANG Zhidong1   JIN Long1   LI Wei1   LI Qiang1   Wang Wei2   DAI Xiaofeng3*  

1 Department of Diagnostic Radiology, the Second Affiliated Hospital of Air Force Medical University, Xi'an 710038, Chian

2 Department of Nuclear Medicine, the Second Affiliated Hospital of Air Force Medical University, Xi'an 710038, China

3 Department of Medical Imaging, 96604 Military Hospital of China People's Liberation Army, Lanzhou 730030, China

Corresponding author: DAI X F, E-mail: 154458713@qq.com

Conflicts of interest   None.

Received  2024-02-20
Accepted  2024-09-02
DOI: 10.12015/issn.1674-8034.2024.09.009
Cite this article as: CHEN J J, WANG Z D, JIN L, et al. The effect of methadone maintenance treatment on degree centrality in heroin dependent patients: a resting state fMRI study[J]. Chin J Magn Reson Imaging, 2024, 15(9): 47-52. DOI:10.12015/issn.1674-8034.2024.09.009.

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