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• Clinical Article •
Value of cardiac magnetic resonance left atrial strain analysis based on tissue feature tracking in the assessment of left ventricular diastolic dysfunction in hypertrophic cardiomyopathy
YUE Xuantong  YANG Kai  LI Jinghui  YIN Gang  ZHAO Shihua  LU Minjie 

Cite this article as: YUE X T, YANG K, LI J H, et al. Value of cardiac magnetic resonance left atrial strain analysis based on tissue feature tracking in the assessment of left ventricular diastolic dysfunction in hypertrophic cardiomyopathy[J]. Chin J Magn Reson Imaging, 2024, 15(9): 60-67. DOI:10.12015/issn.1674-8034.2024.09.011.


[Abstract] Objective To explore the value of cardiac magnetic resonance (CMR) left atrial strain (LAS) in the diagnosis of left ventricular diastolic dysfunction (LVDD) in hypertrophic cardiomyopathy (HCM).Materials and Methods The clinical data, echocardiography and CMR parameters of 103 patients with HCM diagnosed in Beijing Fuwai Hospital from February 2021 to August 2022 were retrospectively analyzed. According to the results of echocardiography, the patients were divided into 28 patients with LVDD group (group A) and 75 patients with no obvious LVDD group (group B). Independent sample t test, non-parametric test, Chi-square test and other statistical methods were mainly used to compare clinical baseline data, basic parameters of CMR, left ventricular strain (LVS) and LAS parameters of group A and group B, respectively. Meanwhile, logistic regression analysis was used to screen independent related factors of LVDD.Results Patients in group A were older [median age 53.0 (43.2, 66.8) years], had higher rates of New York Heart Association (NYHA) Ⅲ-Ⅳ (60.7%), and higher rates of clinical symptoms such as syncope (32.1%) and sudden cardiac death (32.1%). Compared with group B, left atrial anteroposterior diameter (LAD-AP), left ventricular end-systolic volume index (ESVi), left ventricular mass index (LVMi) and the proportion of left ventricular outflow tract obstruction (LVOTO) were significantly increased in group A (P<0.05). The passive strain (εe), peak positive strain rate (SRs), early peak negative strain rate (SRe) and late peak negative strain rate (SRa) were significantly decreased (P<0.05). Multivariate logistic regression analysis showed that LVOTO [odds ratio (OR)=4.127, 95% confidence interval (CI): 1.488-11.450, P=0.006] and SRa (OR=4.672, 95% CI: 1.624-13.441, P=0.004) were independently correlated with LVDD, and SRa had high diagnostic efficacy, the area under the curve (AUC) of the receiver operator characteristic (ROC) that distinguishes LVDD is 0.717.Conclusions CMR LAS can reflect LVDD in patients with HCM. SRa has a certain diagnostic efficacy for LVDD, which is a potential diagnostic index.
[Keywords] hypertrophic cardiomyopathy；strain；magnetic resonance imaging；feature tracking；left ventricular diastolic function

YUE Xuantong1, 2   YANG Kai1   LI Jinghui1   YIN Gang1   ZHAO Shihua1   LU Minjie1*  

1 Department of Magnetic Resonance Imaging, Fuwai Hospital, State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China

2 Department of Radiology, Sichuan Science City Hospital, Mianyang 621000, China

Corresponding author: LU M J, E-mail: coolkan@163.com

Conflicts of interest   None.

Received  2024-04-20
Accepted  2024-09-10
DOI: 10.12015/issn.1674-8034.2024.09.011
Cite this article as: YUE X T, YANG K, LI J H, et al. Value of cardiac magnetic resonance left atrial strain analysis based on tissue feature tracking in the assessment of left ventricular diastolic dysfunction in hypertrophic cardiomyopathy[J]. Chin J Magn Reson Imaging, 2024, 15(9): 60-67. DOI:10.12015/issn.1674-8034.2024.09.011.

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