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• Clinical Article •
Correlation of full-volume IVIM quantitative parameters with neurovascular invasion, MSI status, and Ki-67 index in rectal adenocarcinoma
JIANG Wenli  JIANG Wei  WEI Xin  CHEN Yuanyuan  LIU Xinjie  CHEN Jinhua  CHEN Weijuan 

Cite this article as: JIANG W L, JIANG W, WEI X, et al. Correlation of full-volume IVIM quantitative parameters with neurovascular invasion, MSI status, and Ki-67 index in rectal adenocarcinoma[J]. Chin J Magn Reson Imaging, 2024, 15(9): 80-85, 93. DOI:10.12015/issn.1674-8034.2024.09.014.


[Abstract] Objective To investigate the correlation of intravoxel incoherent motion (IVIM) whole-tumor volume parameter with perineural invasion (PNI), lymphovascular invasion (LVI), microsatellite instability (MSI) status and Ki-67 index in patients with rectal adenocarcinoma.Materials and Methods Imaging and clinical data of 136 patients with rectal adenocarcinoma were retrospectively analyzed, and the true diffusion coefficient (D), pseudo-diffusion coefficient (D*), and perfusion fraction (f) of the full volume parameter of IVIM of the lesion were measured. The patients were grouped according to pathological reports of PNI status, LVI status, MSI and Ki-67 index, and the relationship between each quantitative parameter and the pathological characteristics of the tumors was analyzed by using independent samples t-test or Mann-Whitney U test.Results The D value in the PNI-negative group of rectal adenocarcinoma [(1.174±0.164) ×10-3 mm2/s] was significantly lower than that in the positive group [(1.270±0.206) ×10-3 mm2/s] (t=-3.033, P=0.003), the f value in the LVI-negative group 0.172 (0.158, 0.193) was significantly lower than that in the positive group 0.188 (0.168, 0.237) (Z =-2.435, P=0.015), and the f-value of the Ki-67 low expression group (0.175±0.035) was significantly lower than that of the high expression group (0.188±0.038) (t=-2.097, P=0.038). The difference in D, D*, and f values between the high microsatellite instability group and the low microsatellite instability group was not statistically significant (P>0.05).Conclusions The full volume quantitative parameters of IVIM can reflect the pathological characteristics of rectal adenocarcinoma to a certain extent, and can be used as an important imaging index for preoperative assessment of the biological behavior of rectal adenocarcinoma.
[Keywords] rectal tumor；adenocarcinoma；magnetic resonance imaging；intravoxel incoherent motion；perineural invasion；lymphovascular invasion；microsatellite instability state；Ki-67

JIANG Wenli   JIANG Wei   WEI Xin   CHEN Yuanyuan   LIU Xinjie   CHEN Jinhua   CHEN Weijuan*  

Department of Radiology, Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China

Corresponding author: CHEN W J, E-mail: chenweijuan@hospital.cqmu.edu.cn

Conflicts of interest   None.

ACKNOWLEDGMENTS  ACKNOWLEDGMENTS 2022 Chongqing Science and Health Joint Medical (including Traditional Chinese Medicine) Research Project 2022MSXM136
Received  2024-05-06
Accepted  2024-08-26
DOI: 10.12015/issn.1674-8034.2024.09.014
Cite this article as: JIANG W L, JIANG W, WEI X, et al. Correlation of full-volume IVIM quantitative parameters with neurovascular invasion, MSI status, and Ki-67 index in rectal adenocarcinoma[J]. Chin J Magn Reson Imaging, 2024, 15(9): 80-85, 93. DOI:10.12015/issn.1674-8034.2024.09.014.

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