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• Clinical Article •
Application of high b-value DWI generated based on diffusion model to assess local recurrence after radical treatment of prostate cancer
DENG Wenyou  GUO Xiaofang  HU Kui  HU Lei 

Cite this article as: DENG W Y, GUO X F, HU K, et al. Application of high b-value DWI generated based on diffusion model to assess local recurrence after radical treatment of prostate cancer[J]. Chin J Magn Reson Imaging, 2024, 15(9): 86-93. DOI:10.12015/issn.1674-8034.2024.09.015.


[Abstract] Objective To investigate the value of generating high b-value diffusion weighted imaging (DWI) based on diffusion model for the assessment of local recurrence after radical treatment of prostate cancer.Materials and Methods Retrospective analysis of the clinical and imaging data of 63 patients with biochemical recurrence (BCR) after radical radiotherapy (RT) or radical prostatectomy (RP) for prostate cancer, including 21 patients in the RT group and 42 patients in the RP group. DWI images calculated using the patient's initial apparent diffusion coefficient (ADC) maps were input into the prostate DWI generated model to obtain the generated high b-value (b=2000 s/mm2) DWI maps. The image quality of the calculated DWI and the generated DWI was evaluated by 3 readers, and the risk of recurrence was scored in all cases according to the Prostate Imaging for Recurrence Reporting (PI-RR) system score. Multi-reader multi-case receiver operating characteristic (MRMC-ROC) curve were used to compare the differences in diagnostic efficacy between different readers. Grade score agreement was tested using intragroup correlation coefficients.Results All three readers rated the image quality of the generated DWI group better than that of the calculated DWI group (P=0.002, 0.003, 0.002). The difference in the total PI-RR scores between the generated DWI and calculated DWI groups of the RT group by the three readers was statistically significant (P=0.031, 0.049, 0.041). The difference in PI-RR total score between the generated DWI and calculated DWI groups was statistically significant (P=0.034, 0.049, 0.036). The range of area under the curve (AUC) values for PI-RR total score prediction of the occurrence of localized recurrence in the RT and RP groups by the three readers using the generated DWI was categorized as 0.884-0.924 and 0.926-0.947; the range of AUC value for PI- RR total score prediction of the occurrence of local recurrence in the RT and RP groups by the three readers using the calculated DWI was categorized as 0.783-0.792 and 0.843-0.893. After combining the cases in RT and RP groups, the PI-RR total score was used to predict the status of local recurrence in all the patients, and the range of AUC values for the generated DWI group and the calculated DWI group were 0.912-0.930 and 0.797-0.858.Conclusions High b-value DWI generated based on the diffusion model can significantly improve the diagnostic efficacy of local recurrence after radical treatment of prostate cancer.
[Keywords] prostate cancer；magnetic resonance imaging；diffusion model；diffusion weighted imaging；radical treatment；local recurrence

DENG Wenyou1   GUO Xiaofang1   HU Kui1   HU Lei2*  

1 Department of Radiology, Hubei Cancer Hospital, Wuhan 430079, China

2 Department of Radiology, Guangdong Provincial People's Hospital, Guangzhou 510080, China

Corresponding author: HU L, E-mail: hulei@gdph.org.cn

Conflicts of interest   None.

Received  2024-05-15
Accepted  2024-08-09
DOI: 10.12015/issn.1674-8034.2024.09.015
Cite this article as: DENG W Y, GUO X F, HU K, et al. Application of high b-value DWI generated based on diffusion model to assess local recurrence after radical treatment of prostate cancer[J]. Chin J Magn Reson Imaging, 2024, 15(9): 86-93. DOI:10.12015/issn.1674-8034.2024.09.015.

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