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Research progress on the hyperarousal of insomnia treated by acupuncture based on the default mode network
LI Mufeng  LIU Chengyong  WAN Qingyun  WANG Xiaoqiu  LIU Yongkang  CAO Ziqiong  ZHANG Yuting  WU Wenzhong 

Cite this article as: LI M F, LIU C Y, WAN Q Y, et al. Research progress on the hyperarousal of insomnia treated by acupuncture based on the default mode network[J]. Chin J Magn Reson Imaging, 2024, 15(9): 130-134, 145. DOI:10.12015/issn.1674-8034.2024.09.022.


[Abstract] The hyperarousal model is one of the important theories explaining the occurrence and maintenance of insomnia disorder (ID), yet few studies have explored the neuroimaging mechanisms of hyperarousal in ID. Research has found that ID patients often exhibit symptoms of emotional abnormalities and memory impairment, which are closely related to the functional abnormalities of the default mode network (DMN). Therefore, damage to the DMN may be one of the mechanisms of ID pathogenesis. Acupuncture may regulate the activity and functional connectivity changes of the DMN, suppress the state of cerebral hyperarousal, and thus improve ID symptoms. This article systematically reviews the mechanisms of hyperarousal in ID from molecular genetics, neuroendocrinology, heart rate variability, polysomnography, and neuroimaging perspectives. It explores the relationship between hyperarousal and the DMN, synthesizes the neuroimaging evidence of acupuncture regulation of hyperarousal in ID patients, and analyzes the connection between hyperarousal and the DMN. The aim is to provide neuroimaging evidence for the study of acupuncture intervention mechanisms in ID and to offer insights for future research directions, such as exploring from the levels of brain network connections and neuronal cells, increasing sample sizes, employing multimodal imaging techniques, and combining emerging analytical methods to more comprehensively reveal the brain effect mechanisms of acupuncture treatment for ID.
[Keywords] insomnia；hyperarousal；default mode network；acupuncture；mechanism of brain effect；magnetic resonance imaging

LI Mufeng1   LIU Chengyong2   WAN Qingyun2   WANG Xiaoqiu3   LIU Yongkang4   CAO Ziqiong1   ZHANG Yuting1   WU Wenzhong2*  

1 The First School of Clinical Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, China

2 Department of Acupuncture and Moxibustion Rehabilitation, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing 210029, China

3 Physical Examination Center, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing 210029, China

4 Department of Radiology, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing 210029, China

Corresponding author: WU W Z, E-mail: Maerta_zhong@hotmail.com

Conflicts of interest   None.

Received  2024-06-07
Accepted  2024-09-10
DOI: 10.12015/issn.1674-8034.2024.09.022
Cite this article as: LI M F, LIU C Y, WAN Q Y, et al. Research progress on the hyperarousal of insomnia treated by acupuncture based on the default mode network[J]. Chin J Magn Reson Imaging, 2024, 15(9): 130-134, 145. DOI:10.12015/issn.1674-8034.2024.09.022.

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