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Research progress on brain structure and functional magnetic resonance imaging in patients with knee osteoarthritis pain
ZHOU Peng  CHEN Fei  DAI Zhenyu 

Cite this article as: ZHOU P, CHEN F, DAI Z Y. Research progress on brain structure and functional magnetic resonance imaging in patients with knee osteoarthritis pain[J]. Chin J Magn Reson Imaging, 2024, 15(9): 140-145. DOI:10.12015/issn.1674-8034.2024.09.024.


[Abstract] Knee osteoarthritis (KOA) is a very common and disabling joint disease. Pain is the main clinical symptom and the pathological mechanism is complex. With the application and development of neuroimaging technology in KOA pain research, the central nervous system is considered to play a crucial role in the occurrence and development of KOA pain. MRI is a cutting-edge technology to study the central nervous system. It is widely used in the study of brain central remodeling of pain, and can more intuitively show the changes of brain structure and function in patients with KOA pain. This article reviews the research on the KOA pain using structural MRI (sMRI) and resting-state functional MRI (rs-fMRI). It mainly including changes in gray matter volume and cortical thickness in patients with KOA pain, abnormalities in white matter microstructure integrity, and rs-fMRI studies on brain low-frequency amplitude (ALFF), regional homogeneity (ReHo), functional connectivity (FC), and brain network changes in KOA pain patients. The aim of this study is to evaluate the association between neuroimaging markers and KOA pain, and to enrich the understanding of the changes of brain sMRI and rs-fMRI in patients with KOA pain.
[Keywords] knee osteoarthritis；magnetic resonance imaging；structural magnetic resonance imaging；resting-state functional magnetic resonance imaging；pain

ZHOU Peng   CHEN Fei   DAI Zhenyu*  

Department of Radiology, Sixth Affiliated Hospital of Nantong University (Yancheng Third People's Hospital), Yancheng 224008, China

Corresponding author: DAI Z Y, E-mail: ycsydzy@163.com

Conflicts of interest   None.

Received  2024-03-05
Accepted  2024-08-02
DOI: 10.12015/issn.1674-8034.2024.09.024
Cite this article as: ZHOU P, CHEN F, DAI Z Y. Research progress on brain structure and functional magnetic resonance imaging in patients with knee osteoarthritis pain[J]. Chin J Magn Reson Imaging, 2024, 15(9): 140-145. DOI:10.12015/issn.1674-8034.2024.09.024.

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