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• Clinical Article •
Imaging study of real-time fMRI neurofeedback training based on the nucleus ambiguus to improve obesity
QIAO Qi  ZHOU Jing  HE Junya  LI Xin  ZHOU Yang  SUN Yongbing  LI Zhonglin  ZOU Zhi  WU Xiaoling  LI Hao  LI Yongli 

Cite this article as: QIAO Q, ZHOU J, HE J Y, et al. Imaging study of real-time fMRI neurofeedback training based on the nucleus ambiguus to improve obesity[J]. Chin J Magn Reson Imaging, 2024, 15(10): 56-61. DOI:10.12015/issn.1674-8034.2024.10.010.


[Abstract] Objective Exploring the role of functional magnetic resonance imaging neurofeedback (rtfMRI-NF) to modulate bilateral nucleus ambiguus to improve obesity.Materials and Methods A total of 24 obese patients from December 2022 to December 2023 were recruited as study subjects. A 3-week rtfMRI-NF training intervention was conducted on the obese subjects, the Barratt Impulsiveness Scale Version 11 (BIS-11), three-factor eating questionnaire (TFEQ) with its three subscales: Uncontrolled Eating (UE), Cognitive Restriction (CR), and Emotional Eating (EE), the Food Grade Rating Scale, and resting-state functional magnetic resonance imaging datawere collected before and after the intervention. Paired-samples t-tests were used to compare changes in clinical scales before and after the subjects' intervention. Paired-sample t-tests were used to analyse the functional connectivity (FC) values of the obese subjects before and after the 3-week rtfMRI-NF intervention using SPM12 software. Pearson's correlation analysis was performed between the FC values of the statistically significant differences in brain regions and the scores of the clinical scales.Results BIS-11, TFEQ-UE, TFEQ-EE, and food grade scores decreased and TFEQ-CR scores increased after the intervention in obese patients (P<0.05). FC values of the left nucleus ambiguus with the left middle temporal gyrus decreased and those with the left middle frontal gyrus increased after the intervention in obese subjects (P<0.05, GRF-corrected). FC values of the right nucleus ambiguus with the right cerebellum and the right inferior frontal gyrus increased and FC values with the left precuneus decreased (P<0.05, GRF corrected). FC values in the right nucleus ambiguus-right cerebellar area 8 were negatively correlated with TFEQ-UE scores after intervention (r=-0.549, P=0.008), and FC values in the right nucleus ambiguus-left precuneus were positively correlated with BIS-11 scores (r=0.658, P<0.001).Conclusions The rtfMRI-NF intervention may ameliorate poor eating habits in obese patients by altering functional connectivity of the nucleus ambiguus with distributed brain regions of cognitive control, attentional bias, and emotional memory.
[Keywords] obesity；magnetic resonance imaging；real-time functional magnetic resonance imaging of neurofeedback；resting-state functional magnetic resonance imaging；nucleus ambiguus；functional connectivity

QIAO Qi1   ZHOU Jing2   HE Junya3   LI Xin3   ZHOU Yang1   SUN Yongbing1   LI Zhonglin1   ZOU Zhi1   WU Xiaoling4   LI Hao5   LI Yongli2*  

1 Medical Imaging Department, Zhengzhou University People's Hospital/Henan Provincial People's Hospital, Zhengzhou 450003, China

2 Health Management Department, Zhengzhou University People's Hospital/Henan Provincial People's Hospital, Zhengzhou 450003, China

3 Medical Imaging Department, Henan University People's Hospital/Henan Provincial People's Hospital, Zhengzhou 450003, China

4 Nuclear Medicine Department, Zhengzhou University People's Hospital/Henan Provincial People's Hospital, Zhengzhou 450003, China

5 Health Management Department, Fuwai Central China Cardiovascular Hospital, Zhengzhou 450003, China

Corresponding author: LI Y L, E-mail: shyliyongli@126.com

Conflicts of interest   None.

Received  2024-07-05
Accepted  2024-10-10
DOI: 10.12015/issn.1674-8034.2024.10.010
Cite this article as: QIAO Q, ZHOU J, HE J Y, et al. Imaging study of real-time fMRI neurofeedback training based on the nucleus ambiguus to improve obesity[J]. Chin J Magn Reson Imaging, 2024, 15(10): 56-61. DOI:10.12015/issn.1674-8034.2024.10.010.

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