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• Clinical Article •
Assessment of mechanisms of brain functional impairment in adolescent males with internet gaming disorder based on intra- and interhemispheric functional connectivity density
MA Longyao  ZHANG Yong  TAO Qiuying  SUN Jieping  DANG Jinghan  WANG Weijian  CHENG Jingliang 

Cite this article as: MA L Y, ZHANG Y, TAO Q Y, et al. Assessment of mechanisms of brain functional impairment in adolescent males with internet gaming disorder based on intra- and interhemispheric functional connectivity density[J]. Chin J Magn Reson Imaging, 2024, 15(10): 69-73, 79. DOI:10.12015/issn.1674-8034.2024.10.012.


[Abstract] Objective To assess the mechanism of brain functional impairment, the intra- and interhemispheric functional connectivity density (FCD) analysis was applied to investigate abnormal alterations in functional connectivity within brain regions in adolescent males with internet gaming disorder.Materials and Methods Global FCD calculation on resting-state functional magnetic resonance images of 55 individuals with internet gaming disorder and demographically matched 50 healthy controls. The global FCD was then divided into ipsilateral and contralateral components. The global, intrahemisphere, and interhemispheric FCD between internet gaming disorder group and healthy control group were analyzed using a two-sample t-test. Finally, Pearson correlation analyses were performed between alternations of global, intrahemisphere, and interhemispheric FCD value in individuals with internet gaming disorder and clinical behavior.Results The global FCD differences between the internet gaming disorder and the healthy control were mainly located in the left precuneus, the left posterior cingulate gyrus and the left middle temporal gyrus. Compared to healthy controls, individuals with internet gaming disorder showed decreased interhemispheric FCD in the left precuneus and left posterior cingulate gyrus (t=-5.317, -3.556). In addition, individuals with internet gaming disorder also demonstrated decreased intrahemispheric FCD in the left middle temporal gyrus, the left precuneus, and the left posterior cingulate gyrus (t =-5.044, -5.359, -4.183) (voxel level P<0.005, cluster level P<0.05, Gaussian random fields corrected).Conclusions Functional intrahemispheric and interhemispheric connectivity abnormalities within default mode network regions are observed in individuals with internet gaming disorder. This study will provide new insights into the pathophysiologic mechanisms and clinical diagnosis and treatment of individuals with internet gaming disorder.
[Keywords] internet gaming disorder；magnetic resonance imaging；functional connectivity density；asymmetry；resting-state functional magnetic resonance imaging；default mode network

MA Longyao   ZHANG Yong*   TAO Qiuying   SUN Jieping   DANG Jinghan   WANG Weijian   CHENG Jingliang  

Department of MRI, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450002, China

Corresponding author: ZHANG Y, E-mail: zzuzhangyong2013@163.com

Conflicts of interest   None.

Received  2024-06-03
Accepted  2024-10-10
DOI: 10.12015/issn.1674-8034.2024.10.012
Cite this article as: MA L Y, ZHANG Y, TAO Q Y, et al. Assessment of mechanisms of brain functional impairment in adolescent males with internet gaming disorder based on intra- and interhemispheric functional connectivity density[J]. Chin J Magn Reson Imaging, 2024, 15(10): 69-73, 79. DOI:10.12015/issn.1674-8034.2024.10.012.

[1]
PAULUS F W, OHMANN S, VON GONTARD A, et al. Internet gaming disorder in children and adolescents: a systematic review[J]. Dev Med Child Neurol, 2018, 60(7): 645-659. DOI: 10.1111/dmcn.13754.
[2]
LIU F, DENG H J, ZHANG Q, et al. Symptoms of Internet gaming disorder among male college students in Nanchong, China[J/OL]. BMC Psychiatry, 2022, 22(1): 142 [2024-06-02]. https://pubmed.ncbi.nlm.nih.gov/35193532/. DOI: 10.1186/s12888-022-03778-6.
[3]
FIRST M B. Diagnostic and statistical manual of mental disorders, 5th edition, and clinical utility[J]. J Nerv Ment Dis, 2013, 201(9): 727-729. DOI: 10.1097/NMD.0b013e3182a2168a.
[4]
SALERNO L, BECHERI L, PALLANTI S. ADHD-gaming disorder comorbidity in children and adolescents: a narrative review[J/OL]. Children, 2022, 9(10): 1528 [2024-06-02]. https://pubmed.ncbi.nlm.nih.gov/36291464/. DOI: 10.3390/children9101528.
[5]
BERLOFFA S, SALVATI A, D'ACUNTO G, et al. Internet gaming disorder in children and adolescents with attention deficit hyperactivity disorder[J/OL]. Children, 2022, 9(3): 428 [2024-06-02]. https://pubmed.ncbi.nlm.nih.gov/35327800/. DOI: 10.3390/children9030428.
[6]
DONG H H, WANG M, ZHANG J L, et al. Reduced frontostriatal functional connectivity and associations with severity of Internet gaming disorder[J/OL]. Addict Biol, 2021, 26(4): e12985 [2024-06-02]. https://pubmed.ncbi.nlm.nih.gov/33236526/. DOI: 10.1111/adb.12985.
[7]
MESTRE-BACH G, GRANERO R, FERNÁNDEZ-ARANDA F, et al. Independent component analysis for Internet gaming disorder[J]. Dialogues Clin Neurosci, 2023, 25(1): 14-23. DOI: 10.1080/19585969.2023.2168135.
[8]
XU X F, MA X F, NI H S, et al. Mindfulness meditation training reduces gaming cravings by reshaping the functional connectivity between the default mode network and executive control-related brain regions[J]. Biol Psychiatry Cogn Neurosci Neuroimaging, 2024, 9(8): 827-836. DOI: 10.1016/j.bpsc.2024.04.011.
[9]
TOMASI D, VOLKOW N D. Functional connectivity density mapping[J]. Proc Natl Acad Sci USA, 2010, 107(21): 9885-9890. DOI: 10.1073/pnas.1001414107.
[10]
WEI Y R, HAN S Q, CHEN J L, et al. Abnormal interhemispheric and intrahemispheric functional connectivity dynamics in drug-naïve first-episode schizophrenia patients with auditory verbal hallucinations[J]. Hum Brain Mapp, 2022, 43(14): 4347-4358. DOI: 10.1002/hbm.25958.
[11]
CHENG B C, ZHOU Y S, KWOK V P Y, et al. Altered functional connectivity density and couplings in postpartum depression with and without anxiety[J]. Soc Cogn Affect Neurosci, 2022, 17(8): 756-766. DOI: 10.1093/scan/nsab127.
[12]
JIANG Y, CHEN Y, ZHENG R P, et al. More than just statics: temporal dynamic changes in inter- and intrahemispheric functional connectivity in first-episode, drug-naive patients with major depressive disorder[J/OL]. Front Hum Neurosci, 2022, 16: 868135 [2024-06-02]. https://pubmed.ncbi.nlm.nih.gov/35463932/. DOI: 10.3389/fnhum.2022.868135.
[13]
DU X, YANG Y X, GAO P H, et al. Compensatory increase of functional connectivity density in adolescents with Internet gaming disorder[J]. Brain Imaging Behav, 2017, 11(6): 1901-1909. DOI: 10.1007/s11682-016-9655-x.
[14]
CHEN C Y, YEN J Y, WANG P W, et al. Altered functional connectivity of the Insula and nucleus accumbens in Internet gaming disorder: a resting state fMRI study[J]. Eur Addict Res, 2016, 22(4): 192-200. DOI: 10.1159/000440716.
[15]
YOUH J, HONG J S, HAN D H, et al. Comparison of electroencephalography (EEG) coherence between major depressive disorder (MDD) without comorbidity and MDD comorbid with Internet gaming disorder[J]. J Korean Med Sci, 2017, 32(7): 1160-1165. DOI: 10.3346/jkms.2017.32.7.1160.
[16]
GUO X N, DUAN X J, CHEN H, et al. Altered inter- and intrahemispheric functional connectivity dynamics in autistic children[J]. Hum Brain Mapp, 2020, 41(2): 419-428. DOI: 10.1002/hbm.24812.
[17]
BATTLE D E. Diagnostic and statistical manual of mental disorders (DSM)[J]. CoDAS, 2013, 25(2): 191-192. DOI: 10.1590/s2317-17822013000200017.
[18]
WIDYANTO L, MCMURRAN M. The psychometric properties of the Internet addiction test[J]. Cyberpsychol Behav, 2004, 7(4): 443-450. DOI: 10.1089/cpb.2004.7.443.
[19]
CAVANNA A E, TRIMBLE M R. The precuneus: a review of its functional anatomy and behavioural correlates[J]. Brain, 2006, 129(3): 564-583. DOI: 10.1093/brain/awl004.
[20]
SOLDEVILA-MATÍAS P, ALBAJES-EIZAGIRRE A, RADUA J, et al. Precuneus and insular hypoactivation during cognitive processing in first-episode psychosis: systematic review and meta-analysis of fMRI studies[J/OL]. Rev Psiquiatr Salud Ment, 2020: S1888-S9891(20)30100-2 [2024-06-02]. https://pubmed.ncbi.nlm.nih.gov/32988773/. DOI: 10.1016/j.rpsm.2020.08.001.
[21]
ZHOU B Q, CHEN Y, ZHENG R P, et al. Alterations of static and dynamic functional connectivity of the nucleus accumbens in patients with major depressive disorder[J/OL]. Front Psychiatry, 2022, 13: 877417 [2024-06-02]. https://pubmed.ncbi.nlm.nih.gov/35615457/. DOI: 10.3389/fpsyt.2022.877417.
[22]
ROLLS E T. The cingulate cortex and limbic systems for emotion, action, and memory[J]. Brain Struct Funct, 2019, 224(9): 3001-3018. DOI: 10.1007/s00429-019-01945-2.
[23]
SUN J T, HU B, CHEN T Q, et al. Internet addiction-induced brain structure and function alterations: a systematic review and meta-analysis of voxel-based morphometry and resting-state functional connectivity studies[J]. Brain Imaging Behav, 2023, 17(3): 329-342. DOI: 10.1007/s11682-023-00762-w.
[24]
KING D L, DELFABBRO P H. The cognitive psychology of Internet gaming disorder[J]. Clin Psychol Rev, 2014, 34(4): 298-308. DOI: 10.1016/j.cpr.2014.03.006.
[25]
KIM S J, EOM H, JUNG Y H, et al. Brain functional connectivity during and after imagery of gaming and alternative leisure activities in patients with Internet gaming disorder[J/OL]. Neurosci Lett, 2022, 772: 136451 [2024-06-02]. https://pubmed.ncbi.nlm.nih.gov/35041909/. DOI: 10.1016/j.neulet.2022.136451.
[26]
ZHANG J T, YAO Y W, POTENZA M N, et al. Effects of craving behavioral intervention on neural substrates of cue-induced craving in Internet gaming disorder[J/OL]. Neuroimage Clin, 2016, 12: 591-599 [2024-06-02]. https://pubmed.ncbi.nlm.nih.gov/27699148/. DOI: 10.1016/j.nicl.2016.09.004.
[27]
LYU D, STIEGER J R, XIN C, et al. Causal evidence for the processing of bodily self in the anterior precuneus[J/OL]. Neuron, 2023, 111(16): 2502-2512.e4 [2024-06-02]. https://pubmed.ncbi.nlm.nih.gov/37295420/. DOI: 10.1016/j.neuron.2023.05.013.
[28]
MENON V. 20 years of the default mode network: a review and synthesis[J]. Neuron, 2023, 111(16): 2469-2487. DOI: 10.1016/j.neuron.2023.04.023.
[29]
ZHEN S J, ZHANG X L, YE S M, et al. The proportion of peer players and online game addiction in adolescents: a moderated mediation model[J]. Educ Meas Eval, 2017(8): 46-52. DOI: 10.16518/j.cnki.emae.2017.08.010.
[30]
WANG M, ZHENG H, DU X X, et al. Mapping Internet gaming disorder using effective connectivity: a spectral dynamic causal modeling study[J/OL]. Addict Behav, 2019, 90: 62-70 [2024-06-02]. https://pubmed.ncbi.nlm.nih.gov/30366150/. DOI: 10.1016/j.addbeh.2018.10.019.
[31]
BURIANOVÁ H, FAIZO N L, GRAY M, et al. Altered functional connectivity in mesial temporal lobe epilepsy[J/OL]. Epilepsy Res, 2017, 137: 45-52 [2024-06-02]. https://pubmed.ncbi.nlm.nih.gov/28923408/. DOI: 10.1016/j.eplepsyres.2017.09.001.
[32]
KIEHL K A, SMITH A M, MENDREK A, et al. Temporal lobe abnormalities in semantic processing by criminal psychopaths as revealed by functional magnetic resonance imaging[J]. Psychiatry Res, 2004, 130(3): 297-312. DOI: 10.1016/j.pscychresns.2004.02.002.
[33]
WOOLNOUGH O, DONOS C, MURPHY E, et al. Spatiotemporally distributed frontotemporal networks for sentence reading[J/OL]. Proc Natl Acad Sci U S A, 2023, 120(17): e2300252120 [2024-06-02]. https://pubmed.ncbi.nlm.nih.gov/37068244/. DOI: 10.1073/pnas.2300252120.
[34]
WANG G J, SHOKRI KOJORI E, YUAN K, et al. Inhibition of food craving is a metabolically active process in the brain in obese men[J]. Int J Obes, 2020, 44(3): 590-600. DOI: 10.1038/s41366-019-0484-z.
[35]
CHEN X L, CHEN H, LIU J L, et al. Functional connectivity alterations in reward-related circuits associated with non-suicidal self-injury behaviors in drug-naïve adolescents with depression[J/OL]. J Psychiatr Res, 2023, 163: 270-277 [2024-06-02]. https://pubmed.ncbi.nlm.nih.gov/37244065/. DOI: 10.1016/j.jpsychires.2023.05.068.
[36]
GAO X Y, ZHANG M Z, YANG Z G, et al. Explore the effects of overweight and smoking on spontaneous brain activity: independent and reverse[J/OL]. Front Neurosci, 2022, 16: 944768 [2024-06-02]. https://pubmed.ncbi.nlm.nih.gov/36312021/. DOI: 10.3389/fnins.2022.944768.
[37]
DONG G H, POTENZA M N. Risk-taking and risky decision-making in Internet gaming disorder: implications regarding online gaming in the setting of negative consequences[J/OL]. J Psychiatr Res, 2016, 73: 1-8 [2024-06-02]. https://pubmed.ncbi.nlm.nih.gov/26656573/. DOI: 10.1016/j.jpsychires.2015.11.011.
[38]
DUBOC V, DUFOURCQ P, BLADER P, et al. Asymmetry of the brain: development and implications[J/OL]. Annu Rev Genet, 2015, 49: 647-672 [2024-06-02]. https://pubmed.ncbi.nlm.nih.gov/26442849/. DOI: 10.1146/annurev-genet-112414-055322.
[39]
PINTO D, MARTINS R, MACEDO A, et al. Brain hemispheric asymmetry in schizophrenia and bipolar disorder[J]. J Clin Med, 2023, 12(10): 3421. DOI: 10.3390/jcm12103421.
[40]
MESULAM M M. Temporopolar regions of the human brain[J]. Brain, 2023, 146(1): 20-41. DOI: 10.1093/brain/awac339.
[41]
GOLDBERG E, TULVISTE J. Large-scale distributed networks and cerebral hemispheres[J/OL]. Cortex, 2022, 152: 53-58 [2024-06-02]. https://pubmed.ncbi.nlm.nih.gov/35525128/. DOI: 10.1016/j.cortex.2022.03.010.
[42]
LIU G F, HUO E D, LIU H H, et al. Development and emergence of functional network asymmetry in 3- to 9-month-old infants[J/OL]. Cortex, 2022, 154: 390-404 [2024-06-02]. https://pubmed.ncbi.nlm.nih.gov/35930891/. DOI: 10.1016/j.cortex.2022.06.009.
[43]
KIM H, KIM Y K, GWAK A R, et al. Resting-state regional homogeneity as a biological marker for patients with Internet gaming disorder: a comparison with patients with alcohol use disorder and healthy controls[J/OL]. Prog Neuropsychopharmacol Biol Psychiatry, 2015, 60: 104-111 [2024-06-02]. https://pubmed.ncbi.nlm.nih.gov/25689820/. DOI: 10.1016/j.pnpbp.2015.02.004.
[44]
WANG L, WU L, LIN X, et al. Dysfunctional default mode network and executive control network in people with Internet gaming disorder: independent component analysis under a probability discounting task[J/OL]. Eur Psychiatry, 2016, 34: 36-42 [2024-06-02]. https://pubmed.ncbi.nlm.nih.gov/26928344/. DOI: 10.1016/j.eurpsy.2016.01.2424.
[45]
ZHOU W R, ZHANG Z J, YANG B, et al. Sex difference in neural responses to gaming cues in Internet gaming disorder: implications for why males are more vulnerable to cue-induced cravings than females[J/OL]. Neurosci Lett, 2021, 760: 136001 [2024-06-02]. https://pubmed.ncbi.nlm.nih.gov/34090939/. DOI: 10.1016/j.neulet.2021.136001.

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