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• Clinical Article •
Assessment of mechanisms of brain functional impairment in adolescent males with internet gaming disorder based on intra- and interhemispheric functional connectivity density
MA Longyao  ZHANG Yong  TAO Qiuying  SUN Jieping  DANG Jinghan  WANG Weijian  CHENG Jingliang 

Cite this article as: MA L Y, ZHANG Y, TAO Q Y, et al. Assessment of mechanisms of brain functional impairment in adolescent males with internet gaming disorder based on intra- and interhemispheric functional connectivity density[J]. Chin J Magn Reson Imaging, 2024, 15(10): 69-73, 79. DOI:10.12015/issn.1674-8034.2024.10.012.


[Abstract] Objective To assess the mechanism of brain functional impairment, the intra- and interhemispheric functional connectivity density (FCD) analysis was applied to investigate abnormal alterations in functional connectivity within brain regions in adolescent males with internet gaming disorder.Materials and Methods Global FCD calculation on resting-state functional magnetic resonance images of 55 individuals with internet gaming disorder and demographically matched 50 healthy controls. The global FCD was then divided into ipsilateral and contralateral components. The global, intrahemisphere, and interhemispheric FCD between internet gaming disorder group and healthy control group were analyzed using a two-sample t-test. Finally, Pearson correlation analyses were performed between alternations of global, intrahemisphere, and interhemispheric FCD value in individuals with internet gaming disorder and clinical behavior.Results The global FCD differences between the internet gaming disorder and the healthy control were mainly located in the left precuneus, the left posterior cingulate gyrus and the left middle temporal gyrus. Compared to healthy controls, individuals with internet gaming disorder showed decreased interhemispheric FCD in the left precuneus and left posterior cingulate gyrus (t=-5.317, -3.556). In addition, individuals with internet gaming disorder also demonstrated decreased intrahemispheric FCD in the left middle temporal gyrus, the left precuneus, and the left posterior cingulate gyrus (t =-5.044, -5.359, -4.183) (voxel level P<0.005, cluster level P<0.05, Gaussian random fields corrected).Conclusions Functional intrahemispheric and interhemispheric connectivity abnormalities within default mode network regions are observed in individuals with internet gaming disorder. This study will provide new insights into the pathophysiologic mechanisms and clinical diagnosis and treatment of individuals with internet gaming disorder.
[Keywords] internet gaming disorder；magnetic resonance imaging；functional connectivity density；asymmetry；resting-state functional magnetic resonance imaging；default mode network

MA Longyao   ZHANG Yong*   TAO Qiuying   SUN Jieping   DANG Jinghan   WANG Weijian   CHENG Jingliang  

Department of MRI, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450002, China

Corresponding author: ZHANG Y, E-mail: zzuzhangyong2013@163.com

Conflicts of interest   None.

Received  2024-06-03
Accepted  2024-10-10
DOI: 10.12015/issn.1674-8034.2024.10.012
Cite this article as: MA L Y, ZHANG Y, TAO Q Y, et al. Assessment of mechanisms of brain functional impairment in adolescent males with internet gaming disorder based on intra- and interhemispheric functional connectivity density[J]. Chin J Magn Reson Imaging, 2024, 15(10): 69-73, 79. DOI:10.12015/issn.1674-8034.2024.10.012.

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