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• Clinical Article •
To study the brain function of patients with neuropsychiatric lupus based on the functional connectivity of large-scale brain networks
MA Yue  MA Xueying  NI Sha  AN Ning  YANG Chao  QIAO Pengfei 

Cite this article as: MA Y, MA X Y, NI S, et al. To study the brain function of patients with neuropsychiatric lupus based on the functional connectivity of large-scale brain networks[J]. Chin J Magn Reson Imaging, 2024, 15(10): 74-79. DOI:10.12015/issn.1674-8034.2024.10.013.


[Abstract] Objective To analyze the brain function of patients with neuropsychiatric systemic lupus erythematosus (NPSLE) using independent component analysis (ICA), investigating the appearance of cognitive impairment in NPSLE from the perspective of imaging.Materials and Methods Tixty-seven patients with NPSLE admitted to the Rheumatology Department of the Affiliated Hospital of Inner Mongolia Medical University from September 2021 to December 2023 were included, along with 33 healthy controls (HC) recruited during the same period. Resting-state and structural data were collected, and the data were preprocessed using the Dpabi based on the MATLAB. The GIFT was used to analyze the data of both groups of subjects, extracting 30 independent components. After strict matching according to the Yeo 7 network template and confirmation by experienced doctors, 8 networks were constructed by selecting independent components, and the work between different brain networks was calculated. The connectivity between different brain networks was calculated, and the functional connectivity (FC) values between different brain networks were correlated with clinical data and cognitive assessments.Results Compared with HC, the FC between the left frontoparietal network (LFPN) and the sensorimotor network (SMN), the default network (DMN) was reduced in the NPSLE group (P<0.05), and the FC between DMN and SMN, executive control network (ECN) was also reduced (P<0.05). The FC between the LFPN and the visual network (VN) was increased (P<0.05), and the FC between the SMN and the auditory network (AN), salience network (SN), and VN was increased (P<0.05). The correlation results show that the FC between the DMN_SMN was negatively correlated with anti-ds DNA (P=0.028, r=-0.270), the FC between the SMN_SN was negatively correlated with AVL_first 3 times (P=0.006, r=-0.275), and the FC value between the DMN_ECN was positively correlated with hematocrit (P=0.043, r=0.250) and negatively correlated with AVL_first 3 times (P=0.025, r=-0.224).Conclusions In NPSLE, there are varying degrees of changes in functional connectivity between different brain networks, which are related to the presence of lupus autoantibodies, hematological indicators, and neuropsychological assessments, suggesting that changes in brain networks in lupus patients may be related to cognitive impairment.
[Keywords] neuropsychiatric lupus；magnetic resonance imaging；brain network；brain function；cognitive impairment；independent component analysis

MA Yue1, 3   MA Xueying2   NI Sha1   AN Ning1   YANG Chao1   QIAO Pengfei2*  

1 The First Clinical Medical College, Inner Mongolia Medical University, Hohhot 010050, China

2 Department of Imaging Diagnosis, Affiliated Hospital of Inner Mongolia Medical University, Hohhot 010050, China

3 Department of Medical Imaging, Inner Mongolia Aerospace Hospital, Hohhot 010050, China

Corresponding author: QIAO P F, E-mail: qpfff@126.com

Conflicts of interest   None.

Received  2024-06-28
Accepted  2024-10-10
DOI: 10.12015/issn.1674-8034.2024.10.013
Cite this article as: MA Y, MA X Y, NI S, et al. To study the brain function of patients with neuropsychiatric lupus based on the functional connectivity of large-scale brain networks[J]. Chin J Magn Reson Imaging, 2024, 15(10): 74-79. DOI:10.12015/issn.1674-8034.2024.10.013.

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