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• Clinical Article •
Analysis of thalamic glutamate-glutamine complex metabolism and related factors in patients with vestibular migraine
WANG Weitao  LI Xiaozhen  ZHONG Liqun  HUANG Lixian  XU Dan  SHE Wenlong  ZHANG Daopei  ZHANG Huailiang  CHEN Zhengguang 

Cite this article as: WANG W T, LI X Z, ZHONG L Q, et al. Analysis of thalamic glutamate-glutamine complex metabolism and related factors in patients with vestibular migraine[J]. Chin J Magn Reson Imaging, 2024, 15(10): 93-97, 114. DOI:10.12015/issn.1674-8034.2024.10.016.


[Abstract] Objective To explore the metabolic status and bilateral thalamic glutamate-glutamine complex (Glx) in patients with vestibular migraine (vestibular migraine, VM).Materials and Methods Twenty VM patients and 20 healthy controls were selected to detect thalamic Glx in VM group and healthy controls by magnetic resonance spectroscopy (MRS) imaging technology. Relevant data between two groups to analyze the metabolic differences of Glx and their risk factors.Results The healthy controls (n=20) had 2 513.60 ± 998.20 and the left thalamic Glx were 2 386.50 ± 862.03. The right thalamic Glx metabolic values in the VM group (n=20) were 3 712.00 ± 980.80 and 3 350.40 ± 944.20 for the left thalamic Glx. The t-test analysis showed statistical differences in Glx values in the left and left thalamus in the VM group compared with healthy controls (P<0.05). Spearman correlation analysis showed duration of disease, diabetes, hypertension, sleep disturbance, headache and no statistically significant correlation with VM thalamic Glx; Pearson correlation analysis showed that vertigo disorder scale (DHI), SAS anxiety scale and SDS depression scale showed no statistically significant correlation with VM thalamic Glx, and age was statistically associated with left thalamic Glx (r=0.570, P<0.001).Conclusions VM patients had higher bilateral thalamic Glx values than healthy controls. Age was the relevant contributing factor for the elevated Glx in the left thalamus.
[Keywords] vestibular migraine；thalamic；glutamate-glutamine；magnetic resonance spectroscopy；magnetic resonance imaging；cerebral metabolism

WANG Weitao1   LI Xiaozhen2*   ZHONG Liqun3   HUANG Lixian3   XU Dan3   SHE Wenlong3   ZHANG Daopei4   ZHANG Huailiang4   CHEN Zhengguang2*  

1 Beijing University of Chinese Medicine First Clinical College of Medicine, Beijing 100700, China

2 Department of Radiology, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100700, China

3 Department of Neurology, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100700, China

4 Department of Neurology, the First Affiliated Hospital of Henan University of Chinese Medicine/Center for Diagnosis and Treatment of Vertigo in Henan Province/Institute of Vertigo in Henan University of Chinese Medicine, Zhengzhou 450000, China

Corresponding author: CHEN Z G, E-mail: guangchen999@sina.com LI X Z, E-mail: lixiaozhen79@163.com

Conflicts of interest   None.

Received  2024-03-12
Accepted  2024-10-10
DOI: 10.12015/issn.1674-8034.2024.10.016
Cite this article as: WANG W T, LI X Z, ZHONG L Q, et al. Analysis of thalamic glutamate-glutamine complex metabolism and related factors in patients with vestibular migraine[J]. Chin J Magn Reson Imaging, 2024, 15(10): 93-97, 114. DOI:10.12015/issn.1674-8034.2024.10.016.

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