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• Clinical Article •
The value of the magnetic resonance mDIXON-Quant technique in the assessment of alterations in the proton density fat fraction of the infrapatellar fat pad in knee osteoarthritis
ZHAO Baogen  WANG Xiaoying  WANG Shuo  ZHANG Yujin  JI Gang  ZHANG Li 

Cite this article as: ZHAO B G, WANG X Y, WANG S, et al. The value of the magnetic resonance mDIXON-Quant technique in the assessment of alterations in the proton density fat fraction of the infrapatellar fat pad in knee osteoarthritis[J]. Chin J Magn Reson Imaging, 2024, 15(10): 123-128. DOI:10.12015/issn.1674-8034.2024.10.021.


[Abstract] Objective Analysis of alterations in the proton density fat fraction (PDFF) of the infrapatellar fat pad using magnetic resonance-based mDIXON-Quant technique in patients with knee osteoarthritis (KOA), and its correlation with KOA severity.Materials and Methods Prospectively recruited 44 patients with KOA, performing conventional MRI and mDIXON-Quant sequence scans on a total of 70 knees, to measure the PDFF of the infrapatellar fat pad in KOA patients. The severity of the subjects' KOA was evaluated using the whole-organ magnetic resonance imaging score (WORMS). The correlation between the PDFF of the infrapatellar fat pad and the independent scores of the 11 features of the WORMS, and the total scores of each knee were analysed.Results The PDFF of the infrapatellar fat pad was found to be negatively correlated with a number of variables, including the total knee WORMS scores, articular cartilage integrity, marginal osteophytes, subarticular bone attrition, subarticular bone marrow abnormality, subarticular cysts, medial and lateral meniscal integrity, loose bodies, periarticular cysts/bursitis, anterior and posterior cruciate ligament integrity, and synovitis/effusion WORMS (r=-0.94, -0.85, -0.83, -0.80, -0.72, -0.52, -0.54, -0.39, -0.27, -0.27, -0.24, P<0.05). There was no significant correlation with the medial and lateral collateral ligament integrity (r=0.27, P=0.826). The inter-observer agreement was found to be excellent, with an ICC value of 0.793 (P<0.001), and a 95% confidence interval of (0.667-0.875).Conclusions Magnetic resonance mDIXON-Quant technology enables quantitative evaluation of changes in the PDFF of the infrapatellar fat pad in patients with KOA. The PDFF of the infrapatellar fat pad decreases with the progression of KOA severity, suggesting its potential as an objective indicator to reflect the severity of KOA.
[Keywords] knee joint；osteoarthritis；mDIXON-Quant；infrapatellar fat pad；magnetic resonance imaging

ZHAO Baogen   WANG Xiaoying   WANG Shuo   ZHANG Yujin   JI Gang   ZHANG Li*  

Department of Radiology and Nuclear Medicine, the First Hospital of Hebei Medical University, Shijiazhuang 050011, China

Corresponding author: ZHANG L, E-mail:2501799636@qq.com

Conflicts of interest   None.

Received  2024-04-23
Accepted  2024-10-10
DOI: 10.12015/issn.1674-8034.2024.10.021
Cite this article as: ZHAO B G, WANG X Y, WANG S, et al. The value of the magnetic resonance mDIXON-Quant technique in the assessment of alterations in the proton density fat fraction of the infrapatellar fat pad in knee osteoarthritis[J]. Chin J Magn Reson Imaging, 2024, 15(10): 123-128. DOI:10.12015/issn.1674-8034.2024.10.021.

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