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• Clinical Article •
Study on the correlation between DWI, IVIM, and DCE-MRI parameters and Ki-67 expression in soft tissue tumors
ZHANG Yu  CHAI Rongxin  WANG Dezhi 

Cite this article as: ZHANG Y, CHAI R X, WANG D Z. Study on the correlation between DWI, IVIM, and DCE-MRI parameters and Ki-67 expression in soft tissue tumors[J]. Chin J Magn Reson Imaging, 2024, 15(10): 136-140, 147. DOI:10.12015/issn.1674-8034.2024.10.023.


[Abstract] Objective To investigate the correlation between diffusion weighted imaging (DWI), intravoxel incoherent motion (IVIM), and dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) parameters and the expression of Ki-67 in soft tissue tumors.Materials and Methods A retrospective study included 56 patients with pathologically confirmed soft tissue tumors, divided into a high expression group (n=22) with a Ki-67 index of >20% and a low expression group (n=34) with a Ki-67 index of ≤20% according to the Ki-67 index. The study compared DWI, IVIM, and DCE-MRI parameters between the groups, including apparent diffusion coefficient (ADC), pure diffusion coefficient (D), pseudo-diffusion coefficient (D*), perfusion fraction (f), rate constant (Kep), volume transfer constant (Ktrans), and extracellular extravascular space volume fraction (Ve), and analyzed their correlation with Ki-67 index. It also applied the Pearson correlation coefficient to analyze the significant correlation of parameters with the Ki-67 index that showed significant differences between the groups.Results The ADC and D values were significantly higher in the low Ki-67 expression group than in the high expression group, while Ktrans and Kep values were significantly lower (P<0.05 for all). ADC and D values showed a negative correlation with Ki-67 index (r=-0.637, -0.625, P<0.001), whereas Ktrans showed a positive correlation (r=0.263, P=0.050). ADC had the highest area under the curve (AUC) in distinguishing Ki-67 expression status in soft tissue tumors, at 0.920 (0.845-0.994).Conclusions ADC, D, Ktrans, and Kep can effectively predict Ki-67 expression in soft tissue tumors, with ADC and D being the best parameters for predicting the Ki-67 expression status, providing assistance in clinical diagnosis, treatment, and prognosis assessment.
[Keywords] soft tissue tumors；intravoxel incoherent motion；dynamic contrast-enhanced magnetic resonance imaging；Ki-67；magnetic resonance imaging

ZHANG Yu1   CHAI Rongxin2   WANG Dezhi1*  

1 Department of Medical imaging, Zhucheng people's hospital, Weifang 262200, China

2 Department of Radiology, the Affiliated Hospital of Qingdao University, Qingdao 266000, China

Corresponding author: WANG D Z, E-mail: wang6189_cn@163.com

Conflicts of interest   None.

Received  2024-04-24
Accepted  2024-09-10
DOI: 10.12015/issn.1674-8034.2024.10.023
Cite this article as: ZHANG Y, CHAI R X, WANG D Z. Study on the correlation between DWI, IVIM, and DCE-MRI parameters and Ki-67 expression in soft tissue tumors[J]. Chin J Magn Reson Imaging, 2024, 15(10): 136-140, 147. DOI:10.12015/issn.1674-8034.2024.10.023.

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