Functional magnetic resonance imaging research progress of the 5-HT neural circuit to amygdala in the multimorbidity of insomnia disorder and depression

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ZHANG Xueyi JIA Shulei GU Yuang ZHANG Miao CHEN Keke SUN Yongbing ZHOU Jing WU Xiaoling LI Zhonglin ZOU Zhi SHANG Feifei LI Huiqiang YANG Zhiping YOU Yang LI Yongli

Cite this article as: ZHANG X Y, JIA S L, GU Y A, et al. Functional magnetic resonance imaging research progress of the 5-HT neural circuit to amygdala in the multimorbidity of insomnia disorder and depression[J]. Chin J Magn Reson Imaging, 2024, 15(10): 165-170. DOI:10.12015/issn.1674-8034.2024.10.028.

Abstract

[Abstract] Insomnia disorder (ID) and depression are common diseases that affect patients' daily life and physical and mental health. There is a bidirectional relationship between ID and depression, and they often present as multimorbidity, but the mechanism is unclear. The amygdala is a key center of the emotional circuit, and 5-hydroxytryptamine (5-HT) participates in emotion regulation by regulating amygdala activity. 5-HT neural circuit to amygdala is involved in ID and depression. In this review, we illustrated the changes in the structure and function of the amygdala and 5-HT neural circuit to amygdala in patients with ID and depression through functional magnetic resonance imaging (fMRI), with the aim of providing an objective neuroimaging basis for exploring the possible mechanisms of the 5-HT neural circuit to amygdala in the multimorbidity of ID and depression.

[Keywords] insomnia disorder；depression；amygdala；5-hydroxytryptamine；magnetic resonance imaging；positron emission tomography

Contributor Information

ZHANG Xueyi¹ JIA Shulei² GU Yuang² ZHANG Miao¹ CHEN Keke² SUN Yongbing¹ ZHOU Jing³ WU Xiaoling⁴ LI Zhonglin¹ ZOU Zhi¹ SHANG Feifei³ LI Huiqiang⁴ YANG Zhiping⁴ YOU Yang⁴ LI Yongli^3*

¹ Department of Medical Imaging, People's Hospital of Zhengzhou University/Henan Provincial People's Hospital, Zhengzhou 450003, China

² Department of Medical Imaging, Xinxiang Medical University/Henan Provincial People's Hospital, Zhengzhou 450003, China

³ Department of Health Management, People's Hospital of Zhengzhou University/Henan Provincial People's Hospital, Henan Key Laboratory of Chronic Disease Health Management, Zhengzhou 450003, China

⁴ Department of Nuclear Medicine, Henan Provincial People's Hospital/Zhengzhou University People's Hospital, Zhengzhou 450003, China

Corresponding author: LI Y L, E-mail: shyliyongli@126.com

Conflicts of interest None.

Publication Information

Received 2024-06-24

Accepted 2024-10-10

DOI: 10.12015/issn.1674-8034.2024.10.028

Text

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