Share：
Share this content in WeChat
X
[Chinese][PDF]441
• Review •
Progress on brain magnetic resonance imaging in migraine secondary to patent foramen ovale
LI Yuxuan  LIU Yangyingqiu  CAO Jinfeng  SHANG Qun  LUO Xin 

Cite this article as: LI Y X, LIU Y Y Q, CAO J F, et al. Progress on brain magnetic resonance imaging in migraine secondary to patent foramen ovale[J]. Chin J Magn Reson Imaging, 2024, 15(10): 171-175, 216. DOI:10.12015/issn.1674-8034.2024.10.029.


[Abstract] Patent foramen ovale (PFO) is a congenital structural variation of the heart. In recent years, an increasing number of researchers have paid attention to the close relationship between PFO and migraine. MRI has been widely used in neuroscience. Structural magnetic resonance imaging (sMRI) can be used to investigate the anatomy and structure of the brain and further explore the brain structural changes in patients with migraine secondary to PFO. Resting-state functional magnetic resonance imaging (rs-fMRI) offers noninvasive brain functional activity measurement, which provides a possibility to explore the changes of brain function in patients with PFO and migraine. This article reviews the research progress of the correlation between PFO and migraine, the pathophysiological mechanism of migraine caused by PFO, and the application of MRI in migraine secondary to PFO, hoping to provide ideas for clinical diagnosis and treatment, and provide relevant references for follow-up research.
[Keywords] patent foramen ovale；migraine；resting-state functional magnetic resonance imaging；magnetic resonance imaging；brain function；structural magnetic resonance imaging

LI Yuxuan1, 2   LIU Yangyingqiu2   CAO Jinfeng2   SHANG Qun2   LUO Xin2*  

1 School of Medical Imaging, Shandong Second Medical University, Weifang 261053, China

2 Department of Radiology, Zibo Central Hospital, Zibo 255000, China

Corresponding author: LUO X, E-mail: asd0601@126.com

Conflicts of interest   None.

Received  2024-04-24
Accepted  2024-08-02
DOI: 10.12015/issn.1674-8034.2024.10.029
Cite this article as: LI Y X, LIU Y Y Q, CAO J F, et al. Progress on brain magnetic resonance imaging in migraine secondary to patent foramen ovale[J]. Chin J Magn Reson Imaging, 2024, 15(10): 171-175, 216. DOI:10.12015/issn.1674-8034.2024.10.029.

[1]
CALVERT P A, RANA B S, KYDD A C, et al. Patent foramen ovale: anatomy, outcomes, and closure[J]. Nat Rev Cardiol, 2011, 8(3): 148-160. DOI: 10.1038/nrcardio.2010.224.
[2]
Special Committee of Structural Heart Disease of China Human Health Science and Technology Promotion Association, Neurology Branch of Chinese Medical Doctor Association. Chinese expert consensus on the prevention and treatment of patent foramen oval related non-apoplectic disease[J]. Chin Heart J, 2024, 36(2): 125-134. DOI: 10.12125/j.chj.202307041.
[3]
MA W, YUAN Y, WANG S, et al. Neurocardiology: a pressing subject to be developed[J]. Chin J Intern Med, 2024, 63(3): 225-229. DOI: 10.3760/cma.j.cn112138-20231103-00292.
[4]
SPOSATO L A, ALBIN C S W, ELKIND M S V, et al. Patent foramen ovale management for secondary stroke prevention: state-of-the-art appraisal of current evidence[J]. Stroke, 2024, 55(1): 236-247. DOI: 10.1161/STROKEAHA.123.040546.
[5]
SONG J K. Pearls and pitfalls in the transesophageal echocardiographic diagnosis of patent foramen ovale[J/OL]. J Am Soc Echocardiogr, 2023, 36(9): 895-905.e3 [2024-04-23]. https://pubmed.ncbi.nlm.nih.gov/37196905/. DOI: 10.1016/j.echo.2023.05.004.
[6]
LI X L, LIU C, YOU Z S, et al. Experimental study of flexible lumbar single riveting patent foramen ovale occluder implantation under the guidance of intracardiac ultrasound[J]. Chin J Cardiovasc Res, 2024, 22(2): 178-184. DOI: 10.3969/j.issn.1672-5301.2024.02.015.
[7]
LIU K M, WANG B Z, HAO Y S, et al. The correlation between migraine and patent foramen ovale[J/OL]. Front Neurol, 2020, 11: 543485 [2024-04-23]. https://pubmed.ncbi.nlm.nih.gov/33335507/. DOI: 10.3389/fneur.2020.543485.
[8]
ROMANO V, GALLINORO C M, MOTTOLA R, et al. Patent foramen ovale-a not so innocuous septal atrial defect in adults[J/OL]. J Cardiovasc Dev Dis, 2021, 8(6): 60 [2024-04-23]. https://pubmed.ncbi.nlm.nih.gov/34070460/. DOI: 10.3390/jcdd8060060.
[9]
ORSINELLI D A, RAJPAL S. Doing a deep dive on PatentForamenOvale: stay tuned in the PFO world[J]. JACC Cardiovasc Imaging, 2022, 15(2): 190-192. DOI: 10.1016/j.jcmg.2021.09.012.
[10]
ZHANG N S, ROBBINS M S. Migraine[J/OL]. Ann Intern Med, 2023, 176(1): ITC1-ITC16 [2024-04-23]. https://pubmed.ncbi.nlm.nih.gov/36623287/. DOI: 10.7326/aitc202301170.
[11]
KALKMAN D N, COUTURIER E G M, BOUZIANI A E, et al. Migraine and cardiovascular disease: what cardiologists should know[J]. Eur Heart J, 2023, 44(30): 2815-2828. DOI: 10.1093/eurheartj/ehad363.
[12]
ELGENDY I Y, NADEAU S E, BAIREY MERZ C N, et al. Migraine headache: an under-appreciated risk factor for cardiovascular disease in women[J/OL]. J Am Heart Assoc, 2019, 8(22): e014546 [2024-04-23]. https://pubmed.ncbi.nlm.nih.gov/31707945/. DOI: 10.1161/JAHA.119.014546.
[13]
RAIMONDO L, OLIVEIRA Ĺ A F, HEIJ J, et al. Advances in resting state fMRI acquisitions for functional connectomics[J/OL]. Neuroimage, 2021, 243: 118503 [2024-04-23]. https://pubmed.ncbi.nlm.nih.gov/34479041/. DOI: 10.1016/j.neuroimage.2021.118503.
[14]
HE Y J, YAN S Z, LU J. Research advance on resting-state functional magnetic resonance imaging in the early diagnosis of Alzheimer's disease[J]. Chin J Magn Reson Imag, 2024, 15(1): 173-178. DOI: 10.12015/issn.1674-8034.2024.01.029.
[15]
ASHINA S, BENTIVEGNA E, MARTELLETTI P, et al. Structural and functional brain changes in migraine[J]. Pain Ther, 2021, 10(1): 211-223. DOI: 10.1007/s40122-021-00240-5.
[16]
TANG Y S, SUN H Q, PLUMMER C, et al. Association between patent foramen ovale and migraine: evidence from a resting-state fMRI study[J]. Brain Imaging Behav, 2024, 18(4): 720-729. DOI: 10.1007/s11682-024-00868-9.
[17]
CAO W F, SHEN Y B, ZHONG J Q, et al. The patent foramen ovale and migraine: associated mechanisms and perspectives from MRI evidence[J/OL]. Brain Sci, 2022, 12(7): 941 [2024-04-23]. https://pubmed.ncbi.nlm.nih.gov/35884747/. DOI: 10.3390/brainsci12070941.
[18]
SOMMER R J, ROBBINS B T. Migraine and patent foramen ovale: is platelet hyperactivity the underlying mechanism?[J]. JACC Basic Transl Sci, 2022, 7(6): 541-543. DOI: 10.1016/j.jacbts.2022.04.001.
[19]
AHMED Z, SOMMER R J. Reassessing the PFO-migraine trials: are we closer to closure?[J]. J Am Coll Cardiol, 2021, 77(6): 677-679. DOI: 10.1016/j.jacc.2020.12.017.
[20]
TRABATTONI D, BRAMBILLA M, CANZANO P, et al. Migraine in patients undergoing PFO closure: characterization of a platelet-associated pathophysiological mechanism: the LEARNER study[J]. JACC Basic Transl Sci, 2022, 7(6): 525-540. DOI: 10.1016/j.jacbts.2022.02.002.
[21]
DEL SETTE M, ANGELI S, LEANDRI M, et al. Migraine with aura and right-to-left shunt on transcranial Doppler: a case-control study[J]. Cerebrovasc Dis, 1998, 8(6): 327-330. DOI: 10.1159/000015875.
[22]
TRUONG T, SLAVIN L, KASHANI R, et al. Prevalence of migraine headaches in patients with congenital heart disease[J]. Am J Cardiol, 2008, 101(3): 396-400. DOI: 10.1016/j.amjcard.2007.08.047.
[23]
WANG Y L, WANG F Z, ZHANG Y, et al. Association of migraine with patent foramen ovale closure: a systematic review and meta-analysis[J/OL]. Int J Cardiol Heart Vasc, 2022, 39: 100992 [2024-04-23]. https://pubmed.ncbi.nlm.nih.gov/35330668/. DOI: 10.1016/j.ijcha.2022.100992.
[24]
SHI F F, SHA L H, LI H, et al. Recent progress in patent foramen ovale and related neurological diseases: a narrative review[J/OL]. Front Neurol, 2023, 14: 1129062 [2024-04-23]. https://pubmed.ncbi.nlm.nih.gov/37051056/. DOI: 10.3389/fneur.2023.1129062.
[25]
WILMSHURST P T, NIGHTINGALE S, WALSH K P, et al. Effect on migraine of closure of cardiac right-to-left shunts to prevent recurrence of decompression illness or stroke or for haemodynamic reasons[J]. Lancet, 2000, 356(9242): 1648-1651. DOI: 10.1016/s0140-6736(00)03160-3.
[26]
MOJADIDI M K, KUMAR P, MAHMOUD A N, et al. Pooled analysis of PFO occluder device trials in patients with PFO and migraine[J]. J Am Coll Cardiol, 2021, 77(6): 667-676. DOI: 10.1016/J.JACC.2020.11.068.
[27]
DOWSON A, MULLEN M J, PEATFIELD R, et al. Migraine Intervention With STARFlex Technology (MIST) trial: a prospective, multicenter, double-blind, sham-controlled trial to evaluate the effectiveness of patent foramen ovale closure with STARFlex septal repair implant to resolve refractory migraine headache[J]. Circulation, 2008, 117(11): 1397-1404. DOI: 10.1161/CIRCULATIONAHA.107.727271.
[28]
MATTLE H P, EVERS S, HILDICK-SMITH D, et al. Percutaneous closure of patent foramen ovale in migraine with aura, a randomized controlled trial[J]. Eur Heart J, 2016, 37(26): 2029-2036. DOI: 10.1093/eurheartj/ehw027.
[29]
TOBIS J M, CHARLES A, SILBERSTEIN S D, et al. Percutaneous closure of patent foramen ovale in patients with migraine: the PREMIUM trial[J]. J Am Coll Cardiol, 2017, 70(22): 2766-2774. DOI: 10.1016/j.jacc.2017.09.1105.
[30]
QI Y, ZHANG Y S, LUO X H, et al. Efficacy of patent foramen ovale closure for treating migraine: a prospective follow-up study[J]. J Investig Med, 2021, 69(1): 7-12. DOI: 10.1136/jim-2020-001323.
[31]
LING Y Y, WANG M, PAN X D, et al. Clinical features of right-to-left shunt in the different subgroups of migraine[J/OL]. Brain Behav, 2020, 10(3): e01553 [2024-04-23]. https://pubmed.ncbi.nlm.nih.gov/32011802/. DOI: 10.1002/brb3.1553.
[32]
SACCO S, HARRIOTT A M, AYATA C, et al. Microembolism and other links between migraine and stroke: clinical and pathophysiologic update[J]. Neurology, 2023, 100(15): 716-726. DOI: 10.1212/WNL.0000000000201699.
[33]
RAVI D, PARIKH R V, ABOULHOSN J, et al. A new syndrome of patent foramen ovale inducing vasospastic angina andMigraine[J/OL]. JACC Case Rep, 2023, 28: 102132 [2024-04-23]. https://pubmed.ncbi.nlm.nih.gov/38204551/. DOI: 10.1016/j.jaccas.2023.102132.
[34]
GUO Z N, QU Y, GAO Y S, et al. Changes in cerebral autoregulation, stroke-related blood biomarkers, and autonomic regulation after patent foramen ovale closure in severe migraine patients[J]. CNS Neurosci Ther, 2023, 29(10): 3031-3042. DOI: 10.1111/cns.14244.
[35]
CHI N F, HU H H, WANG C Y, et al. Dynamic cerebral autoregulation is an independent functional outcome predictor of mild acute ischemic stroke[J]. Stroke, 2018, 49(11): 2605-2611. DOI: 10.1161/STROKEAHA.118.022481.
[36]
SUDERSHAN A, PUSHAP A C, KUMAR H, et al. A comprehensive investigation into the association between mthfr C677t, A1298c, and ace I/D variants and risk of migraine: an updated meta-analysis of genetic association studies with trial sequential analysis and meta-regression[J]. J Mol Neurosci, 2023, 73(11/12): 884-911. DOI: 10.1007/s12031-023-02164-5.
[37]
BONANNO L, BUONO V L, SALVO S D, et al. Brain morphologic abnormalities in migraine patients: an observational study[J/OL]. J Headache Pain, 2020, 21(1): 39 [2024-04-23]. https://pubmed.ncbi.nlm.nih.gov/32334532/. DOI: 10.1186/s10194-020-01109-2.
[38]
CHRISTENSEN R H, ASHINA H, AL-KHAZALI H M, et al. Differences in cortical morphology in people with and without migraine: a registry for migraine (REFORM) MRI study[J/OL]. Neurology, 2024, 102(9): e209305 [2024-04-23]. https://pubmed.ncbi.nlm.nih.gov/38630960/. DOI: 10.1212/WNL.0000000000209305.
[39]
HU S, HAO Z Q, LI M T, et al. Resting-state abnormalities in functional connectivity of the default mode network in migraine: a meta-analysis[J/OL]. Front Neurosci, 2023, 17: 1136790 [2024-04-23]. https://pubmed.ncbi.nlm.nih.gov/36937687/. DOI: 10.3389/fnins.2023.1136790.
[40]
SHI Y H, ZENG W M, NIE W F, et al. Multi-channel hierarchy functional integration analysis between large-scale brain networks for migraine: an fMRI study[J/OL]. Neuroimage Clin, 2020, 28: 102462 [2024-04-23]. https://pubmed.ncbi.nlm.nih.gov/33395958/. DOI: 10.1016/j.nicl.2020.102462.
[41]
CHOU B C, LERNER A, BARISANO G, et al. Functional MRI and diffusion tensor imaging in migraine: a review of migraine functional and white matter microstructural changes[J/OL]. J Cent Nerv Syst Dis, 2023, 15: 11795735231205413 [2024-04-23]. https://pubmed.ncbi.nlm.nih.gov/37900908/. DOI: 10.1177/11795735231205413.
[42]
SIGNORIELLO E, CIRILLO M, PUOTI G, et al. Migraine as possible red flag of PFO presence in suspected demyelinating disease[J/OL]. J Neurol Sci, 2018, 390: 222-226 [2024-04-23]. https://pubmed.ncbi.nlm.nih.gov/29801894/. DOI: 10.1016/j.jns.2018.04.042.
[43]
YEO J Y P, GOH C X Y, TAN Y K, et al. Evaluating the relationship between right-to-left shunt and white matter hyperintensities in migraine patients: a systematic review and meta-analysis[J/OL]. Front Neurol, 2022, 13: 972336 [2024-04-23]. https://pubmed.ncbi.nlm.nih.gov/36061988/. DOI: 10.3389/fneur.2022.972336.
[44]
IWASAKI A, SUZUKI K, TAKEKAWA H, et al. The relationship between right-to-left shunt and brain white matter lesions in Japanese patients with migraine: a single center study[J/OL]. J Headache Pain, 2017, 18(1): 3 [2024-04-23]. https://pubmed.ncbi.nlm.nih.gov/28063107/. DOI: 10.1186/s10194-016-0714-x.
[45]
ZHANG X Y, ZHOU J, GUO M Y, et al. A systematic review and meta-analysis of voxel-based morphometric studies of migraine[J]. J Neurol, 2023, 270(1): 152-170. DOI: 10.1007/s00415-022-11363-w.
[46]
NEEB L, BASTIAN K, VILLRINGER K, et al. Structural gray matter alterations in chronic migraine: implications for a progressive disease?[J]. Headache, 2017, 57(3): 400-416. DOI: 10.1111/head.13012.
[47]
LI X C. Preliminary study on brain structure and function of multimodal MRI in migraine with patent foramen ovale [D]. Dalian: Dalian Medical University, 2023.
[48]
SHI M, LUO D Q, GUO J, et al. The function of the autonomic nervous system in Asian patients with chronic migraine[J/OL]. Front Neurosci, 2022, 16: 773321 [2024-04-23]. https://pubmed.ncbi.nlm.nih.gov/35495060/. DOI: 10.3389/fnins.2022.773321.
[49]
WEI H L, LI J, GUO X, et al. Functional connectivity of the visual cortex differentiates anxiety comorbidity from episodic migraineurs without aura[J/OL]. J Headache Pain, 2021, 22(1): 40 [2024-04-23]. https://pubmed.ncbi.nlm.nih.gov/34020591/. DOI: 10.1186/s10194-021-01259-x.
[50]
LI Z J, ZHOU J, LAN L, et al. Concurrent brain structural and functional alterations in patients with migraine without aura: an fMRI study[J/OL]. J Headache Pain, 2020, 21(1): 141 [2024-04-23]. https://pubmed.ncbi.nlm.nih.gov/33287704/. DOI: 10.1186/s10194-020-01203-5.
[51]
CAI M J, LIU J W, WANG X X, et al. Spontaneous brain activity abnormalities in migraine: a meta-analysis of functional neuroimaging[J]. Hum Brain Mapp, 2023, 44(2): 571-584. DOI: 10.1002/hbm.26085.
[52]
WEI H L, CHEN J, CHEN Y C, et al. Impaired effective functional connectivity of the sensorimotor network in interictal episodic migraineurs without aura[J/OL]. J Headache Pain, 2020, 21(1): 111 [2024-04-23]. https://pubmed.ncbi.nlm.nih.gov/32928098/. DOI: 10.1186/s10194-020-01176-5.
[53]
QIN Z X, SU J J, HE X W, et al. Disrupted functional connectivity between sub-regions in the sensorimotor areas and cortex in migraine without aura[J/OL]. J Headache Pain, 2020, 21(1): 47 [2024-04-23]. https://pubmed.ncbi.nlm.nih.gov/32375638/. DOI: 10.1186/s10194-020-01118-1.
[54]
TSAI C L, CHOU K H, LEE P L, et al. Shared alterations in hippocampal structural covariance in subjective cognitive decline and migraine[J/OL]. Front Aging Neurosci, 2023, 15: 1191991 [2024-04-23]. https://pubmed.ncbi.nlm.nih.gov/37409010/. DOI: 10.3389/fnagi.2023.1191991.
[55]
RUSSO A, TESSITORE A, SILVESTRO M, et al. Advanced visual network and cerebellar hyperresponsiveness to trigeminal nociception in migraine with aura[J/OL]. J Headache Pain, 2019, 20(1): 46 [2024-04-23]. https://pubmed.ncbi.nlm.nih.gov/31053057/. DOI: 10.1186/s10194-019-1002-3.
[56]
YOUNIS S, HOUGAARD A, NOSEDA R, et al. Current understanding of thalamic structure and function in migraine[J]. Cephalalgia, 2019, 39(13): 1675-1682. DOI: 10.1177/0333102418791595.
[57]
BUCKNER R L, DINICOLA L M. The brain's default network: updated anatomy, physiology and evolving insights[J]. Nat Rev Neurosci, 2019, 20(10): 593-608. DOI: 10.1038/s41583-019-0212-7.
[58]
HAYNE D P, MARTIN P R. Relating photophobia, visual aura, and visual triggers of headache and migraine[J]. Headache, 2019, 59(3): 430-442. DOI: 10.1111/head.13486.

PREV Functional magnetic resonance imaging research progress of the 5-HT neural circuit to amygdala in the multimorbidity of insomnia disorder and depression
NEXT Research progress of brain MRI on the central thalamo-frontal-somatosensory cortex circuit in lifelong premature ejaculation
  


LINK


Tel & Fax: +8610-67113815    E-mail: editor@cjmri.cn