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• Clinical Article •
A study of the seed-point functional connectivity network for the default mode network in patients with mild hepatic encephalopathy
NIU Fang  ZHENG Jiarui  MA Wenfu  MA Wanlong  JIN Yixuan  SUN Meng  DING Xiangchun  WANG Xiaodong 

Cite this article as: NIU F, ZHENG J R, MA W F, et al. A study of the seed-point functional connectivity network for the default mode network in patients with mild hepatic encephalopathy[J]. Chin J Magn Reson Imaging, 2024, 15(11): 1-5, 11. DOI:10.12015/issn.1674-8034.2024.11.001.


[Abstract] Objective Resting-state functional magnetic resonance imaging (rs-fMRI) combined with seed-based functional connectivity (FC) analysis was used to investigate whether there was a difference between the default network (DMN) and the whole brain functional connectivity between patients with hepatitis B virus-related acute-on-chronic liver failure (HBV-ACLF) and minimal hepatic encephalopathy (MHE) and healthy controls (HCs), in order to further explore the underlying mechanism of cognitive dysfunction in HBV-ACLF with MHE patients and HCs, and to provide imaging markers for early diagnosis of HBV-ACLF with MHE.Materials and Methods Rs-fMRI was used to observed the FC of the DMN with the whole brain in 27 patients with HBV-ACLF with MHE and 22 HCs in the resting state, and analyze the differences between the two groups, and correlation analysis was performed with Digit Symbol Test (DST), Number Connection Test A (NCT-A), Montreal Cognitive Assessment (MoCA) scores, blood ammonia and white blood cell count.Results Compared with the HCs group, the FC of the right temporal pole (middle temporal gyrus), left inferior temporal gyrus, right inferior occipital gyrus and left middle occipital gyrus was reduced in the MHE group (P<0.005), the FC value of the right temporal pole was significantly negatively correlated with the MoCA score in the MHE group (r=-0.394, P<0.05), and the FC score of the left inferior temporal gyrus in the MHE group was significantly negatively correlated with blood ammonia (r=-0.456, P<0.05).Conclusions The internal functional integration of DMN in patients with HBV-ACLF with MHE is altered, and the reduction or interruption of FC may be the pathophysiological mechanism of early cognitive decline in patients with HBV-ACLF with MHE.
[Keywords] minimal hepatic encephalopathy；magnetic resonance imaging；resting state functional connectivity；psychometric tests；default mode network；cognitive function

NIU Fang1   ZHENG Jiarui2   MA Wenfu1   MA Wanlong3   JIN Yixuan1   SUN Meng1   DING Xiangchun3   WANG Xiaodong4, 5*  

1 Clinical Medical College of Ningxia Medical University, Yinchuan750004, China

2 Department of Radiology, Yinchuan Maternal and Child Health Care Hospital (Yinchuan Children's Hospital), Yinchuan750004, China

3 Department of Infectious Diseases, the General Hospital of Ningxia Medical University, Yinchuan750004, China

4 Department of Radiology, the General Hospital of Ningxia Medical University, Yinchuan750004, China

5 Key Laboratory of Brain Diseases, the General Hospital of Ningxia Medical University, Yinchuan750004, China

Corresponding author: WANG X D, E-mail: xdw80@yeah.net

Conflicts of interest   None.

Received  2024-04-17
Accepted  2024-10-11
DOI: 10.12015/issn.1674-8034.2024.11.001
Cite this article as: NIU F, ZHENG J R, MA W F, et al. A study of the seed-point functional connectivity network for the default mode network in patients with mild hepatic encephalopathy[J]. Chin J Magn Reson Imaging, 2024, 15(11): 1-5, 11. DOI:10.12015/issn.1674-8034.2024.11.001.

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