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• Clinical Article •
The application value of brain functional network topology properties in evaluating tDCS in improving cognitive impairment after ischemic stroke
ZHONG Jiali  JING Xiaoshan  LIANG Ying  PENG Ruchen  XIN Ruiqiang 

Cite this article as: ZHONG J L, JING X S, LIANG Y, et al. The application value of brain functional network topology properties in evaluating tDCS in improving cognitive impairment after ischemic stroke[J]. Chin J Magn Reson Imaging, 2024, 15(11): 6-11. DOI:10.12015/issn.1674-8034.2024.11.002.


[Abstract] Objective To explore the application value of brain functional network topology properties in evaluating transcranial Direct Current Stimulation (tDCS) in improving cognitive impairment after ischemic stroke (IS).Materials and Methods Prospective inclusion of 51 IS patients with mild or above cognitive impairment, randomly assigned to an electrical stimulation group (26 cases) and a control group (25 cases) for 15 days of routine rehabilitation treatment, as well as tDCS treatment or sham stimulation. Collect cognitive scale scores and resting state functional magnetic resonance imaging (rs-fMRI) data from two groups of subjects before and after treatment. Constructing a brain functional network based on graph theory analysis methods, comparing the differences in global and local topological properties between two groups of subjects before and after treatment, as well as their correlation with cognitive scale scores.Results The Mini Mental State Examination (MMSE) and Montreal Cognitive Assessment (MoCA) scores of the electrical stimulation group and the control group after treatment were both better than before treatment, but the improvement in MMSE and MoCA scores of the electrical stimulation group after treatment was higher than that of the control group, with P<0.05. The global efficiency (Eg) and normalized clustering coefficient (γ) of the electrical stimulation group increased after treatment (P<0.05, FDR correction); The nodal efficiency (Enodal) of the inferior frontal gyrus in the left triangle and the nodal clustering coefficient (Cp nodal) of the superior frontal gyrus and posterior central gyrus in the left orbit increased (P<0.05, FDR correction). There was no significant difference in the global and local network topology properties between the control group after treatment. Correlation analysis found that the increase in Eg in the electrical stimulation group after treatment was positively correlated with the improvement in MMSE score (r=0.47, P=0.02).Conclusions The improvement of cognitive function in IS patients by tDCS combined with conventional rehabilitation therapy is superior to that of conventional rehabilitation therapy alone. At the same time, tDCS can have an impact on the global or local properties results of some brain functional networks, and the increase of Eg may be an effective predictor of cognitive function rehabilitation.
[Keywords] ischemic stroke；cognitive impairment；magnetic resonance imaging；resting state functional network；graph theory

ZHONG Jiali1   JING Xiaoshan2   LIANG Ying3   PENG Ruchen1   XIN Ruiqiang1*  

1 Department of Medical Imaging, Beijing Luhe Hospital, Capital Medical University, Beijing101149, China

2 Department of Rehabilitation, Beijing Luhe Hospital, Capital Medical University, Beijing101149, China

3 Department of Biomedical Engineering, Capital Medical University, Beijing100069, China

Corresponding author: XIN R Q, E-mail: rxin@ccmu.edu.cn

Conflicts of interest   None.

Received  2024-07-19
Accepted  2024-11-10
DOI: 10.12015/issn.1674-8034.2024.11.002
Cite this article as: ZHONG J L, JING X S, LIANG Y, et al. The application value of brain functional network topology properties in evaluating tDCS in improving cognitive impairment after ischemic stroke[J]. Chin J Magn Reson Imaging, 2024, 15(11): 6-11. DOI:10.12015/issn.1674-8034.2024.11.002.

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