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• Clinical Article •
Structural changes in gray matter of the brain in patients with early-onset schizophrenia: A meta-analysis of voxel-based morphometry
WANG Lu  LIU Ruishan  LIAO Juan  XIA Linfeng  ZHUO Lihua  LI Hongwei 

Cite this article as: WANG L, LIU R S, LIAO J, et al. Structural changes in gray matter of the brain in patients with early-onset schizophrenia: a meta-analysis of voxel-based morphometry[J]. Chin J Magn Reson Imaging, 2024, 15(11): 17-23. DOI:10.12015/issn.1674-8034.2024.11.004.


[Abstract] Objective An effective integrative analysis of brain regions with significant gray matter volume (GMV) abnormalities in early-onset schizophrenia (EOS) was conducted to identify the most consistent GMV changes in EOS, thus revealing possible pathophysiologic mechanisms of EOS.Materials and Methods A systematic searched of the PubMed, Web of Science, Embase, as well as the China Knowledge Network and Wanfang databases for studies that used voxel morphometrics (VBM) to explore the differences in whole-brain GMV between EOS patients and healthy controls were conducted, and the data were analyzed using Seed-based d Mapping with Permutation of Subject Images (SDM-PSI) software, from the time of database establishment until April 30, 2024, Brain regions with significant abnormalities in GMV in the patients with EOS relative to healthy controls were extracted and summarized, and the data were analyzed using SDM-PSI software.Results A total of 11 studies that met the criteria were included, with a total sample size of 729 cases, including 366 patients with EOS and 363 healthy controls. Voxel-based meta-analysis showed that GMV was significantly reduced in the right superior temporal gyrus extending to the right middle temporal gyrus, and temporal pole in patients with EOS, and no brain regions with significantly increased GMV were identified (P<0.005; peak height Z>1; cluster range>10 voxels).Conclusions In the present study, the voxel-based meta-analysis method revealed that the more consistently GMV significantly abnormal brain region in EOS patients was the right superior temporal gyrus (extending to the right middle temporal gyrus and temporal pole), and these findings will help to further deepen the understanding of the pathophysiological mechanisms of schizophrenia.
[Keywords] early-onset schizophrenia；gray matter volume；voxel-based morphometry；magnetic resonance imaging；meta-analysis

WANG Lu1, 2   LIU Ruishan1   LIAO Juan1, 2   XIA Linfeng3   ZHUO Lihua2*   LI Hongwei1*  

1 Department of Radiology, the Third Hospital of Mianyang, Sichuan Mental Health Center, Mianyang621000, China

2 Medical Imaging College, North Sichuan Medical College, Nanchong637000, China

3 Department of Neurosurgery, the Third Hospital of Mianyang, Sichuan Mental Health Center, Mianyang621000, China

Corresponding author: ZHUO L H, E-mail: 1029511104@qq.com LI H W, E-mail: lhw6321@163.com

Conflicts of interest   None.

Received  2024-06-26
Accepted  2024-09-23
DOI: 10.12015/issn.1674-8034.2024.11.004
Cite this article as: WANG L, LIU R S, LIAO J, et al. Structural changes in gray matter of the brain in patients with early-onset schizophrenia: a meta-analysis of voxel-based morphometry[J]. Chin J Magn Reson Imaging, 2024, 15(11): 17-23. DOI:10.12015/issn.1674-8034.2024.11.004.

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