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• Clinical Article •
Study on brain microstructure in patients with white matter hyperintensities and depressive symptoms based on multimodal MRI
ZHOU Ying  ZHANG Shuo  TAN Zhongjian  LU Yikun  GAO Jinyang  HAN Xiao  MA Lifang  CUI Fangyuan 

Cite this article as: ZHOU Y, ZHANG S, TAN Z J, et al. Study on brain microstructure in patients with white matter hyperintensities and depressive symptoms based on multimodal MRI[J]. Chin J Magn Reson Imaging, 2024, 15(11): 24-31. DOI:10.12015/issn.1674-8034.2024.11.005.


[Abstract] Objective To explore the changes in brain microstructure in patients with white matter hyperintensities and depression symptoms based on multimodal MRI.Materials and Methods Thirty-five patients with white matter hyperintensities and mild depression, as well as 35 healthy individuals matched by age, gender and years of education were recruited. Clinical assessments and MRI data were collected. Tract-based spatial statistics (TBSS) and voxel-based morphometry (VBM) were used to investigate the microstructural changes of the brain between the two groups, and the correlation between the structural differences and the Hamilton Depression Scale (HAMD) score was analyzed.Results Using the statistics of no-threshold-freecluster enhancement (TFCE) for permutation test and applying (family-wise error, FEW) to correct for multiple comparisons of the study results (P<0.05). Significantly lower FA (P＜0.05) values were found in areas including the body of corpus callosum, bilateral posterior thalamic radiation, the right retrolenticular part of internal capsule, and right superior longitudinal fasciculus in the experimental group were statistically significant compared to the healthy group (P<0.05); the experimental group showed a reduction in gray matter volume in brain regions such as bilateral hippocampus, right parahippocampal gyrus, anterior central gyrus, superior temporal gyrus, middle temporal gyrus, and lingual gyrus (FDR corrected, P<0.05). The FA value of the corpus callosum was negatively correlated with the volume of the right hippocampus (r=0.495, P=0.004), and significantly negatively correlated with the HAMD score (r=-0.530, P=0.002).Conclusions Patients with white matter hyperintensities and depression symptoms have extensive involvement of white matter fibers and changes in gray matter microstructure. The integrity of white matter fibers in the body of corpus callosum may be related to depressive symptom, which can provide reference for early clinical identification and intervention.
[Keywords] white matter hyperintensities；depression；cerebral microstructure；white matter；gray matter；magnetic resonance imaging；multimodal magnetic resonance imaging；diffusion tensor imaging；tract-based spatial statistics；voxel-based morphometry

ZHOU Ying1   ZHANG Shuo1   TAN Zhongjian2   LU Yikun1   GAO Jinyang1   HAN Xiao1   MA Lifang1   CUI Fangyuan1*  

1 Department of Neurology, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing100700, China

2 Department of Radiology, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing100700, China

Corresponding author: CUI F Y, E-mail: xmly2015@126.com

Conflicts of interest   None.

Received  2024-04-05
Accepted  2024-11-08
DOI: 10.12015/issn.1674-8034.2024.11.005
Cite this article as: ZHOU Y, ZHANG S, TAN Z J, et al. Study on brain microstructure in patients with white matter hyperintensities and depressive symptoms based on multimodal MRI[J]. Chin J Magn Reson Imaging, 2024, 15(11): 24-31. DOI:10.12015/issn.1674-8034.2024.11.005.

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