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• Clinical Article •
Application of MOLLI T1 mapping quantitative technology in the assessment of pediatric brain development
YANG Xue  JIA Fenglin  MA Xinmao  LI Xuesheng  LI Pei  ZHANG Lu  LIAO Yi  NING Gang  QU Haibo 

Cite this article as: YANG X, JIA F L, MA X M, et al. Application of MOLLI T1 mapping quantitative technology in the assessment of pediatric brain development[J]. Chin J Magn Reson Imaging, 2024, 15(11): 32-38. DOI:10.12015/issn.1674-8034.2024.11.006.


[Abstract] Objective To explore the value of the modified Look-Locker inversion recovery (MOLLI) T1 mapping quantitative technique in evaluating the development of brain in children quantitatively.Materials and Methods Fifty-three children with normal head magnetic resonance imaging results were included, and optimized MOLLI and magnetization prepared 2 rapid acquisition gradient echoes (MP2RAGE) sequences were used to perform T1 mapping quantitative analysis on 36 brain regions of each subject. We evaluate the consistency of T1 values in each brain region obtained from two sequences, compared the differences in T1 values in each brain region of the two sequences, and analyze the correlation between T1 values in each brain region of the two sequences and age.Results The intraclass correlation co-efficient (ICC) for the MOLLI sequence and MP2RAGE sequence in all brain regions were greater than 0.8 (P<0.001), except for the bilateral dorsal pontine and cerebral peduncle. The differences in T1 values between the two sequences in each brain region were statistically significant (P<0.05, FDR-corrected), the T1 values in each brain region of the MOLLI group were higher than those in the MP2RAGE group. The T1 values of each brain region in both sequences were negatively correlated with age (P<0.001).Conclusions The optimized MOLLI sequence can be used for the quantitative evaluation of brain development in children, showing good consistency with MP2RAGE sequence, and accurately quantifying T1 values of brain regions, providing a new sequence selection for the study of the nervous system of fetuses and children.
[Keywords] brain development；children；magnetic resonance imaging；modified Look-Locker inversion recover sequence；T1 mapping；myelin sheath

YANG Xue1   JIA Fenglin1   MA Xinmao1   LI Xuesheng1   LI Pei1   ZHANG Lu2   LIAO Yi1   NING Gang1   QU Haibo1*  

1 Department of Radiology, Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu610041, China

2 Department of Operation Management and Evaluation, West China Second University Hospital, Sichuan University, Chengdu610041, China

Corresponding author: QU H B, E-mail: windowsqhb@126.com

Conflicts of interest   None.

Received  2023-12-20
Accepted  2024-10-11
DOI: 10.12015/issn.1674-8034.2024.11.006
Cite this article as: YANG X, JIA F L, MA X M, et al. Application of MOLLI T1 mapping quantitative technology in the assessment of pediatric brain development[J]. Chin J Magn Reson Imaging, 2024, 15(11): 32-38. DOI:10.12015/issn.1674-8034.2024.11.006.

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