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• Clinical Article •
Clinical value of apparent diffusion coefficient in predicting distant metastasis in hepatic alveolar echinococcosis
DANZENG Yeang  BAO Haihua  ZHANG Xueqian  LONG Changyou  XING Yujie  TIAN Pengqi 

Cite this article as: DANZENG Y A, BAO H H, ZHANG X Q, et al. Clinical value of apparent diffusion coefficient in predicting distant metastasis in hepatic alveolar echinococcosis[J]. Chin J Magn Reson Imaging, 2024, 15(11): 90-95. DOI:10.12015/issn.1674-8034.2024.11.014.


[Abstract] Objective To explore the clinical value of apparent diffusion coefficient (ADC) in predicting distant metastasis of hepatic alveolar echinococcosis (HAE).Materials and Methods A retrospective analysis was conducted on 267 patients diagnosed with HAE at Qinghai University Affiliated Hospital from January 2019 to March 2024, including 88 cases with distant metastasis and 179 cases without metastasis. Clinical and imaging information was recorded, and the maximum apparent diffusion coefficient (ADCmax), minimum apparent diffusion coefficient (ADCmin), and mean apparent diffusion coefficient (ADCmean) of the solid part and peripheral zone of the lesions were measured on diffusion-weighted imaging (DWI). Statistical methods were used to compare the differences between patients with distant metastasis and those without metastasis in terms of age, sex, ethnicity, ADCmax, ADCmin, and ADCmean of the solid part and peripheral zone of the lesions. Receiver operating characteristic (ROC) curves were plotted, and the area under the curve (AUC) was calculated to evaluate the diagnostic performance of each parameter. The optimal diagnostic cutoff values and their corresponding sensitivities and specificities were calculated.Results There were no statistically significant differences in age, sex, or ethnicity between the group with distant metastasis of HAE and the group without metastasis (P>0.05). Regarding the solid part of the lesions, there were no significant differences in ADCmax, ADCmin, or ADCmean between the group with distant metastasis and the group without metastasis (P>0.05). However, significant differences in ADCmax, ADCmin, and ADCmean were observed between the two groups in the peripheral zone of the lesions (P<0.05). Additionally, regardless of metastasis occurrence, ADCmax, ADCmin, and ADCmean in the peripheral zone were lower than those in the solid component. ROC curve analysis demonstrated that ADC values in the peripheral zone could effectively predict distant metastasis of HAE. Among them, the combined index showed the best efficacy in predicting distant metastasis of HAE, the AUC is 0.955 (95% CI: 0.923-0.977), with a sensitivity of 93.2% and a specificity of 86.0%.Conclusions The ADC values in the peripheral zone have good predictive value for assessing whether HAE will develop distant metastasis in the clinical setting. The combined use of various parameters can further enhance the predictive efficacy of distant metastasis in HAE, facilitating the realization of individualized and precise medical decision-making.
[Keywords] hepatic alveolar echinococcosis；distant metastasis；peripheral zone；apparent diffusion coefficient；magnetic resonance imaging

DANZENG Yeang   BAO Haihua*   ZHANG Xueqian   LONG Changyou   XING Yujie   TIAN Pengqi  

Image Center of Affiliated Hospital of Qinghai University, Xining810001, China

Corresponding author: BAO H H, E-mail: baohelen@sina.com

Conflicts of interest   None.

Received  2024-05-04
Accepted  2024-11-08
DOI: 10.12015/issn.1674-8034.2024.11.014
Cite this article as: DANZENG Y A, BAO H H, ZHANG X Q, et al. Clinical value of apparent diffusion coefficient in predicting distant metastasis in hepatic alveolar echinococcosis[J]. Chin J Magn Reson Imaging, 2024, 15(11): 90-95. DOI:10.12015/issn.1674-8034.2024.11.014.

[1]
WANG Z, BIAN H Y, LI J Q, et al. Detection and subtyping of hepatic echinococcosis from plain CT images with deep learning: a retrospective, multicentre study[J/OL]. Lancet Digit Health, 2023, 5(11): e754-e762 [2024-01-02]. https://pubmed.ncbi.nlm.nih.gov/37770335/. DOI: 10.1016/S2589-7500(23)00136-X.
[2]
BAUMANN S, SHI R, LIU W Y, et al. Worldwide literature on epidemiology of human alveolar echinococcosis: a systematic review of research published in the twenty-first century[J]. Infection, 2019, 47(5): 703-727. DOI: 10.1007/s15010-019-01325-2.
[3]
YU X K, ZHANG L, MA W J, et al. An overview of hepatic echinococcosis and the characteristic CT and MRI imaging manifestations[J]. Infect Drug Resist, 2021, 14: 4447-4455. DOI: 10.2147/IDR.S331957.
[4]
ALVI M A, ALI R M A, KHAN S, et al. Past and present of diagnosis of echinococcosis: a review (1999-2021)[J/OL]. Acta Trop, 2023, 243: 106925 [2023-11-04]. https://pubmed.ncbi.nlm.nih.gov/37080264/. DOI: 10.1016/j.actatropica.2023.106925.
[5]
DEIBEL A, MEYER ZU SCHWABEDISSEN C, HUSMANN L, et al. Characteristics and clinical course of alveolar echinococcosis in patients with immunosuppression-associated conditions: a retrospective cohort study[J/OL]. Pathogens, 2022, 11(4): 441 [2023-11-04]. https://pubmed.ncbi.nlm.nih.gov/35456117/. DOI: 10.3390/pathogens11040441.
[6]
GRAETER T, SHI R, BAO H H, et al. Intrahepatic manifestation and distant extrahepatic disease in alveolar echinococcosis: a multicenter cohort study[J]. Acta Radiol, 2021, 62(8): 997-1005. DOI: 10.1177/0284185120951958.
[7]
BRUNETTI E, KERN P, VUITTON D A, et al. Expert consensus for the diagnosis and treatment of cystic and alveolar echinococcosis in humans[J]. Acta Trop, 2010, 114(1): 1-16. DOI: 10.1016/j.actatropica.2009.11.001.
[8]
ALTMAYER S, ARMELIN L M, PEREIRA J S, et al. MRI with DWI improves detection of liver metastasis and selection of surgical candidates with pancreatic cancer: a systematic review and meta-analysis[J]. Eur Radiol, 2024, 34(1): 106-114. DOI: 10.1007/s00330-023-10069-5.
[9]
MAHESHWARI E, NOUGARET S, STEIN E B, et al. Update on MRI in evaluation and treatment of endometrial cancer[J]. Radiographics, 2022, 42(7): 2112-2130. DOI: 10.1148/rg.220070.
[10]
JIANG L L, ZHANG J B, CHEN J, et al. rFOV-DWI and SMS-RESLOVE-DWI in patients with thyroid nodules: comparison of image quality and apparent diffusion coefficient measurements[J]. Magn Reson Imaging, 2022, 91: 62-68. DOI: 10.1016/j.mri.2022.05.010.
[11]
MICHOUX N F, CERANKA J W, VANDEMEULEBROUCKE J, et al. Repeatability and reproducibility of ADC measurements: a prospective multicenter whole-body-MRI study[J]. Eur Radiol, 2021, 31(7): 4514-4527. DOI: 10.1007/s00330-020-07522-0.
[12]
MEYER H J, MARTIN M, DENECKE T. DWI of the breast - possibilities and limitations[J]. Rofo, 2022, 194(9): 966-974. DOI: 10.1055/a-1775-8572.
[13]
KAYADIBI Y, KOCAK B, UCAR N, et al. Radioproteomics in breast cancer: prediction of ki-67 expression with MRI-based radiomic models[J/OL]. Acad Radiol, 2022, 29(Suppl 1): S116-S125 [2023-12-15]. https://pubmed.ncbi.nlm.nih.gov/33744071/. DOI: 10.1016/j.acra.2021.02.001.
[14]
TORGERSON P R, KELLER K, MAGNOTTA M, et al. The global burden of alveolar echinococcosis[J/OL]. PLoS Negl Trop Dis, 2010, 4(6): e722 [2023-10-12]. https://pubmed.ncbi.nlm.nih.gov/20582310/. DOI: 10.1371/journal.pntd.0000722.
[15]
WANG Q, KANG Y L, WANG H, et al. Effect of PTCD combined with albendazole on liver function and marginal ADC value in patients with end-stage hepatic alveolar echinococcosis[J]. Chin J Magn Reson Imag, 2019, 10(4): 254-257. DOI: 10.12015/issn.1674-8034.2019.04.003.
[16]
REN B, WANG J, LIU W Y, et al. Comparison between the MR diffusion weighted imaging and pathology of hepatic alveolar echinococcosis[J]. Chin J Radiol, 2012, 46(1): 57-60. DOI: 10.3760/cma.j.issn.1005-1201.2012.01.014.
[17]
BILGIN S S, GULTEKIN M A, YURTSEVER I, et al. Diffusion tensor imaging can discriminate the primary cell type of intracranial metastases for patients with lung cancer[J]. Magn Reson Med Sci, 2022, 21(3): 425-431. DOI: 10.2463/mrms.mp.2020-0183.
[18]
ZHANG G M, MOU Y L, FAN H N, et al. Growth properties of hepatic alveolar echinococcosis in mice at different stages by MRI[J]. J Clin Radiol, 2022, 41(7): 1370-1374.
[19]
SADE R, KANTARCI M, OGUL H, et al. Differentiation between hepatic alveolar echinococcosis and primary hepatic malignancy with diffusion-weighted magnetic resonance imaging[J]. Diagn Interv Imaging, 2018, 99(3): 169-177. DOI: 10.1016/j.diii.2017.09.007.
[20]
STEFANIAK M, DERDA M, ZMORA P, et al. Risk factors and the character of clinical course of the Echinococcus multilocularis infection in patients in Poland[J/OL]. Pathogens, 2023, 12(2): 199 [2023-12-17]. https://pubmed.ncbi.nlm.nih.gov/36839470/. DOI: 10.3390/pathogens12020199.
[21]
YANG J, BAI J H, ZHANG Y H, et al. Revolution CT hepatic perfusion imaging assessment of peripheral infiltration zone of hepatic alveolar echinococcosis[J]. Chin J Schistosomiasis Contr, 2018, 30(6): 678-681. DOI: 10.16250/j.32.1374.2018123.
[22]
EBERHARDT N, PETERS L, KAPP-SCHWOERER S, et al. 18F-FDG-PET/MR in alveolar echinococcosis: multiparametric imaging in a real-world setting[J/OL]. Pathogens, 2022, 11(3): 348 [2023-10-09]. https://pubmed.ncbi.nlm.nih.gov/35335672/. DOI: 10.3390/pathogens11030348.
[23]
WANG J, DING S, LIU W Y, et al. Value of MR diffusion weighted imaging in assessing the viability of hepatic alveolar echinococcosis[J]. Chin J Radiol, 2015, 49(2): 103-106. DOI: 10.3760/cma.j.issn.1005-1201.2015.02.006.
[24]
LI S X, BAO H H, LI M. Research status and progress of multimodal imaging technique in cerebral alveolar echinococcosis[J]. Chin J Magn Reson Imag, 2021, 12(8): 91-93, 97. DOI: 10.12015/issn.1674-8034.2021.08.020.
[25]
LIU Y M, TIAN F M, SHAN J Y, et al. Kupffer cells: important participant of hepatic alveolar echinococcosis[J/OL]. Front Cell Infect Microbiol, 2020, 10: 8 [2023-12-29]. https://pubmed.ncbi.nlm.nih.gov/32064239/. DOI: 10.3389/fcimb.2020.00008.
[26]
WANG J, GOTTSTEIN B. Immunoregulation in larval Echinococcus multilocularis infection[J]. Parasite Immunol, 2016, 38(3): 182-192. DOI: 10.1111/pim.12292.
[27]
GOTTSTEIN B, STOJKOVIC M, VUITTON D A, et al. Threat of alveolar echinococcosis to public health: a challenge for Europe[J]. Trends Parasitol, 2015, 31(9): 407-412. DOI: 10.1016/j.pt.2015.06.001.
[28]
ŠIMEKOVÁ K, ROSOĽANKA R, SZILÁGYOVÁ M, et al. Alveolar echinococcosis of the liver with a rare infiltration of the adrenal gland[J]. Helminthologia, 2021, 58(1): 100-105. DOI: 10.2478/helm-2021-0002.
[29]
ZHENG J J, WANG J, ZHAO J Q, et al. Diffusion-weighted MRI for the initial viability evaluation of parasites in hepatic alveolar echinococcosis: comparison with positron emission tomography[J]. Korean J Radiol, 2018, 19(1): 40-46. DOI: 10.3348/kjr.2018.19.1.40.
[30]
CALAME P, WECK M, BUSSE-COTE A, et al. Role of the radiologist in the diagnosis and management of the two forms of hepatic echinococcosis[J/OL]. Insights Imaging, 2022, 13(1): 68 [2023-11-03]. https://pubmed.ncbi.nlm.nih.gov/35394226/. DOI: 10.1186/s13244-022-01190-y.
[31]
BECCE F, POMONI A, ULDRY E, et al. Alveolar echinococcosis of the liver: diffusion-weighted MRI findings and potential role in lesion characterisation[J]. Eur J Radiol, 2014, 83(4): 625-631. DOI: 10.1016/j.ejrad.2013.12.025.

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