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Potential of the nuclear overhauser effect in precision medicine: From basic research to clinical applications
ZHAO Nannan  XU Dongyuan  YAN Gen 

Cite this article as: ZHAO N N, XU D Y, YAN G. Potential of the nuclear overhauser effect in precision medicine: From basic research to clinical applications[J]. Chin J Magn Reson Imaging, 2024, 15(11): 227-234. DOI:10.12015/issn.1674-8034.2024.11.036.


[Abstract] The nuclear overhauser effect (NOE) in nuclear magnetic resonance (NMR) spectroscopy is a critical phenomenon that provides essential information on intra- and intermolecular distances and conformations. By analyzing the NOE effect, researchers can gain deeper insights into molecular structures, particularly the three-dimensional conformations of complex biomolecules and pharmaceutical compounds, which are of great significance for the advancement of modern medicine. With the rapid growth of precision medicine, the application potential of the NOE effect in drug design, disease diagnosis, and personalized therapy has become increasingly prominent. This review focuses on the various applications of the NOE effect in precision medicine, with an emphasis on its contributions to elucidating drug-target interactions, detecting conformational changes in biomolecules under pathological conditions, and identifying biomarkers for personalized treatment. Specific case studies and experimental data are incorporated to further explain the role of the NOE effect in bridging basic research and clinical applications. Through this review, the broad application prospects of the NOE effect in modern medicine are demonstrated, and potential breakthroughs in precision medicine are highlighted, offering new directions and insights for future research and applications.
[Keywords] glioblastoma；Alzheimer's disease；nuclear magnetic resonance；nuclear overhauser effect；magnetic resonance imaging；precision medicine

ZHAO Nannan1, 2   XU Dongyuan2   YAN Gen1*  

1 Department of Radiology, Xiamen Medical College Affiliated Second Hospital, Xiamen361000, China

2 Department of Center of Morphological Experiment, Medical College of Yanbian University, Yanji133002, China

Corresponding author: YAN G, E-mail: gyan@stu.edu.cn

Conflicts of interest   None.

Received  2024-06-25
Accepted  2024-11-04
DOI: 10.12015/issn.1674-8034.2024.11.036
Cite this article as: ZHAO N N, XU D Y, YAN G. Potential of the nuclear overhauser effect in precision medicine: From basic research to clinical applications[J]. Chin J Magn Reson Imaging, 2024, 15(11): 227-234. DOI:10.12015/issn.1674-8034.2024.11.036.

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