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Assessment of middle cerebral artery atherosclerotic stenosis by 7.0 T MR HR-VWI: A consistency analysis with DSA
HE Min  DENG Yali  LI Chuan  ZHEN Zhiming  ZUO Meng  WANG Jian  CHEN Wei  CHEN Wei  CHEN Jiafei 

Cite this article as: HE M, DENG Y L, LI C, et al. Assessment of middle cerebral artery atherosclerotic stenosis by 7.0 T MR HR-VWI: A consistency analysis with DSA[J]. Chin J Magn Reson Imaging, 2024, 15(12): 42-47. DOI:10.12015/issn.1674-8034.2024.12.006.


[Abstract] Objective To analyze the accuracy and reproducibility of 7.0 T high resolution vessel wall imaging (HR-VWI) in assessing the degree of atherosclerotic stenosis in the middle cerebral artery (MCA) patients with ischemic stroke.Materials and Methods The present study retrospectively collected data from a total of 47 patients diagnosed with atherosclerosis in the middle cerebral artery at our hospital from September 2022 to November 2023. All patients underwent 7.0 T HR-VWI and digital subtraction angiography (DSA) examinations within 2 weeks. Two senior physicians independently measured the stenosis diameter, stenosis length, inner and outer wall areas at the site of the atherosclerotic plaques in the MCA patients, and the intra-observer and inter-observer consistency was assessed using intra-class correlation coefficient (ICC). The stenotic rate and length of the MCA vessel affected by atherosclerotic plaque are measured by an experienced interventional neurologist, followed by conducting Bland-Altman analysis and correlation analysis to compare these measurements with the mean value obtained through HR-VWI.Results The mean lumen diameter at the most stenotic site was independently measured by two observers for all 47 patients [(1.19±0.49) mm]. Additionally, measurements were also taken for mean plaque length (6.12±3.06 mm), mean inner wall area [(1.88±1.11) mm2], mean outer wall area [(8.99±2.49) mm2], mean normal lumen diameter [(2.31±0.35) mm], and mean inner wall area [(4.74±1.31) mm2] as well as mean outer wall area [(10.54±2.44) mm2]. The ICC values for all measurement was greater than 0.8, and the P value was less than 0.001. In the Bland-Altman analysis of consistency between DSA and HR-VWI in measuring stenotic rate and stenotic length, a high percentage of difference values fell within the mean difference ±1.96 standard deviations: 94.74% (54/57) for stenotic rate and 96.49% (55/57) for stenotic length, with ICC values of 0.944 and 0.897, respectively. Furthermore, strong correlations were observed between the two methods regarding both stenotic rate and stenotic length (r=0.955, P<0.001; r=0.890, P<0.001).Conclusions The 7.0 T HR-VWI demonstrates excellent reproducibility and accuracy in evaluating the degree of atherosclerotic stenosis in the MCA among patients with ischemic stroke.
[Keywords] middle cerebral artery；atherosclerotic stenosis；cerebral arterial thrombosis；high resolution vessel wall imaging；magnetic resonance imaging；7.0 T；digital subtraction angiography

HE Min1   DENG Yali1   LI Chuan1   ZHEN Zhiming1   ZUO Meng2   WANG Jian1   CHEN Wei1   CHEN Wei3   CHEN Jiafei1*  

1 7 T Magnetic Resonance Translation Medicine Research Center, Department of Radiology, Southwest Hospital, Army Medical University (Third Military Medical University), Chongqing400038, China

2 Department of Neurology, Southwest Hospital, Army Medical University (Third Military Medical University), Chongqing400038, China

3 MR Research Collaboration Teams, Siemens Healthineers Ltd., Guangzhou510620, China

Corresponding author: CHEN J F, E-mail: t2mu.singular@163.com

Conflicts of interest   None.

Received  2024-03-30
Accepted  2024-07-12
DOI: 10.12015/issn.1674-8034.2024.12.006
Cite this article as: HE M, DENG Y L, LI C, et al. Assessment of middle cerebral artery atherosclerotic stenosis by 7.0 T MR HR-VWI: A consistency analysis with DSA[J]. Chin J Magn Reson Imaging, 2024, 15(12): 42-47. DOI:10.12015/issn.1674-8034.2024.12.006.

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