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• Clinical Article •
Alterations in gray matter structure in adolescents with non-suicidal self-injury comorbid with depressive disorder
YU Rui  LIU Nian  LIAO Kaike  CHEN Xinyue  PENG Shiji  LI Ying  LI Hangyu 

Cite this article as: YU R, LIU N, LIAO K K, et al. Alterations in gray matter structure in adolescents with non-suicidal self-injury comorbid with depressive disorder[J]. Chin J Magn Reson Imaging, 2024, 15(12): 73-78. DOI:10.12015/issn.1674-8034.2024.12.011.


[Abstract] Objective To explore the characteristics of gray matter structure and clinical symptoms in adolescents with non-suicidal self-injury (NSSI) comorbid with major depressive disorder (MDD).Materials and Methods Forty-six adolescents with NSSI comorbid with MDD (MDD-NSSI group) and 15 adolescents with NSSI without MDD (NSSI group) were included. And 40 healthy controls matched in age and gender were recruited (HC group). The clinical symptoms of participants were assessed using the Self-Rating Depression Scale, Self-Rating Anxiety Scale, Beck Scale for Suicide Ideation, and Ottawa Self-Injury Inventory. A 3.0 T magnetic resonance scanner was used for 3D T1WI high-resolution scanning. Calculate the gray matter volume, thickness, and surface area of all subjects. Analyze the differences in gray matter surface area, thickness, and volume among the three groups and their correlations with clinical symptoms.Results There were no significant differences in age and sex among the three groups (P>0.05). Compared with the HC group, the depression and anxiety scores of the NSSI group and the MDD-NSSI group were increased (F=80.068, 117.630). Compared with the NSSI group, the suicide ideation, anxiety and depression scores of the MDD-NSSI group were also increased (t=-3.138, P<0.05). Compared with the HC group, the NSSI group showed increased surface area in the left transverse temporal gyrus, and decreased volume of the left isthmus of the cingulate gyrus (F=6.739, 4.290, P<0.05). Compared with the HC group, the MDD-NSSI group showed decreased surface area in the left superior parietal gyrus, increased surface area in the left transverse temporal, and increased volume in the left lateral occipital gyrus and the transverse temporal gyrus (F=3.182, 6.739, 3.331, 4.624, P<0.05). The volume of the left isthmus of the cingulate gyrus in the NSSI group was smaller than that in the MDD-NSSI group (F=4.290, P<0.05). The surface area of the left transverse temporal gyrus in the MDD-NSSI group was positively correlated with anxiety, suicide ideation and sensation seeking scores (r=0.320, 0.354, 0.367). The volume of the left isthmus of the cingulate gyrus was positively correlated with sensation seeking score (r=0.383). The volume of the left transverse temporal gyrus was positively correlated with anxiety and suicide ideation scores (r=0.320, 0.314, P<0.05).Conclusions Adolescents with NSSI comorbid with MDD have more extensive gray matter structure abnormalities than those without MDD, and these abnormalities are related to the severity of clinical symptoms, providing an important theoretical basis for an in-depth understanding of this complex mental disorder.
[Keywords] non-suicidal self-injury；major depressive disorder；magnetic resonance imaging；gray matter surface area；gray matter volume

YU Rui1, 3   LIU Nian1, 2, 3*   LIAO Kaike1, 3   CHEN Xinyue1, 3   PENG Shiji1, 3   LI Ying1, 3   LI Hangyu1, 3  

1 Department of Radiology, Affiliated Hospital of North Sichuan Medical College, Nanchong637000, China

2 Functional and Molecular Imaging Key Laboratory of Sichuan Province, Chengdu610041, China

3 School of Medical Imaging, North Sichuan Medical College, Nanchong637000, China

Corresponding author: LIU N, E-mail: 232402432@qq.com

Conflicts of interest   None.

Received  2024-09-11
Accepted  2024-12-10
DOI: 10.12015/issn.1674-8034.2024.12.011
Cite this article as: YU R, LIU N, LIAO K K, et al. Alterations in gray matter structure in adolescents with non-suicidal self-injury comorbid with depressive disorder[J]. Chin J Magn Reson Imaging, 2024, 15(12): 73-78. DOI:10.12015/issn.1674-8034.2024.12.011.

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