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• Clinical Article •
Preliminary study on different stages of Parkinson's Disease combined with amide proton transfer imaging and quantitative susceptibility mapping
YANG Chen  LIAO Qi  JU Chao  WANG Hong  HAO Lu 

Cite this article as: YANG C, LIAO Q, JU C, et al. Preliminary study on different stages of Parkinson's Disease combined with amide proton transfer imaging and quantitative susceptibility mapping[J]. Chin J Magn Reson Imaging, 2024, 15(12): 79-86. DOI:10.12015/issn.1674-8034.2024.12.012.


[Abstract] Objective To analyze the differences of amid proton transfer weighted (APTw) value and magnetic susceptibility value (MSV) of the substantia nigra dentate system between different stages of Parkinson's disease (PD) and healthy control (HC) by amid proton transfer (APT) and quantitative susceptibility mapping (QSM). To evaluate whether the APTw value or MSV in substantia nigra (SN), red nucleus (RN) and dentate nucleus (DN) could serve as imaging findings for determining different stages of Parkinson's disease.Materials and Methods A total of 35 patients with PD and 25 HCs (age and sex matched) were recruited from the Second Affiliated Hospital of Xinjiang Medical University. The PD group was divided into an early-stage PD (ESPD) group of 22 cases and an advanced-stage PD (ASPD) group of 13 cases based on Hoehn-Yahr grading, then, comparing the differences between APTw values and MSV among different regions of nuclei in each group. Finally, the receiver operating characteristic (ROC) curves were used to analyze the diagnostic performance of APT, QSM, and their combined use. The receiver operating characteristic (ROC) curves and DeLong test were used to evaluate the efficiency of APT, QSM and combined parameters. Finally, the correlation of clinical scales with APTw values and MSV were analyzed.Results The APTw values between the ESPD group and the HC group, the ESPD group and the ASPD group, the ASPD group and the HC group in the SN, between the ASPD group and the HC group in the RN, and between the ESPD group and the HC group, the ASPD group and the HC group in the DN show statistically significant differences (P<0.05). The MSV values between the ESPD group and the HC group, the ESPD group and the ASPD group, the ASPD group and the HC group in the SN, between the ASPD group and the HC group, the ASPD group and the ESPD group in the RN, and between the ASPD group and the HC group, the ASPD group and the ESPD group in the DN show statistically significant differences (P<0.05). The area under the curve (AUC) of APT, QSM, and their combination in distinguishing the ESPD group from the HC group are 0.886, 0.792, and 0.926, respectively, with statistically significant differences (P<0.05); in distinguishing the ESPD group from the ASPD group, the AUC are 0.787, 0.885, and 0.939, respectively, with statistically significant differences (P<0.05). There is a positive correlation between the APTw values in the SN and MoCA scores, and a negative correlation between the MSV in the SN, RN and MoCA scores; there is a positive correlation between the APTw values in the SN, RN and MMSE scores, all showing significant differences (P<0.05).Conclusions APT and QSM could be used as imaging indicators for evaluating the stages of PD, and the combined application of APT and QSM can significantly improve diagnostic efficiency.
[Keywords] Parkinson's disease；amide proton transfer imaging；quantitative susceptibility mapping；magnetic resonance imaging；staging

YANG Chen1, 2   LIAO Qi1, 2   JU Chao1, 2   WANG Hong1   HAO Lu1*  

1 Department of Medical Imaging Center, the Second Affiliated Hospital of Xinjiang Medical University, Urumqi830063, China

2 Xinjiang Medical University, Urumqi830063, China

Corresponding author: HAO L, E-mail: 362314559@qq.com

Conflicts of interest   None.

Received  2024-07-16
Accepted  2024-11-22
DOI: 10.12015/issn.1674-8034.2024.12.012
Cite this article as: YANG C, LIAO Q, JU C, et al. Preliminary study on different stages of Parkinson's Disease combined with amide proton transfer imaging and quantitative susceptibility mapping[J]. Chin J Magn Reson Imaging, 2024, 15(12): 79-86. DOI:10.12015/issn.1674-8034.2024.12.012.

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