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• Clinical Article •
Combined analysis based on the characteristics of intracranial atherosclerotic plaque and apparent diffusion coefficient histogram in predicting the recurrence of ischemic stroke
LUO Tong  GAO Yang  WU Qiong  HE Jinlong  WANG Zehua 

Cite this article as: LUO T, GAO Y, WU Q, et al. Combined analysis based on the characteristics of intracranial atherosclerotic plaque and apparent diffusion coefficient histogram in predicting the recurrence of ischemic stroke[J]. Chin J Magn Reson Imaging, 2024, 15(12): 94-100. DOI:10.12015/issn.1674-8034.2024.12.014.


[Abstract] Objective To explore the apparent diffusion coefficient (ADC) histogram and plaque characteristics of patients with symptomatic intracranial atherosclerotic stenosis in the prediction of ischemic stroke recurrence.Materials and Methods This study retrospectively analyzed the clinical data of 114 patients with anterior circulation ischemic stroke who were treated in the Affiliated Hospital of Inner Mongolia Medical University from June 2022 to June 2024. According to clinical and imaging data, the patients were divided into initial stroke group (n=56) and recurrent stroke group (n=58). Compare two groups of patients with clinical data, ADC histogram parameters and characteristics of intracranial atherosclerotic plaque. Compare two groups of patients with clinical data, ADC histogram parameters and characteristics of intracranial atherosclerotic plaque. Using multivariable logistic regression model analysis of independent risk factors for recurrence of ischemic stroke, the receiver operating characteristic (ROC) curve was drawn to analyze the predictive value of clinical data, ADC histogram parameters and intracranial atherosclerotic plaque characteristics for recurrence of ischemic stroke patients.Results Among 114 patients with anterior ischemic stroke, 56 had primary stroke and 58 had recurrent stroke. There were significant differences in hyperhomocysteinemia, ADCmin, kurtosis, intracranial atherosclerotic plaque load and plaque enhancement rate between the primary stroke group and the recurrent stroke group (P<0.05). Multivariate logistic regression analysis showed that kurtosis value, plaque enhancement rate and hyperhomocysteinemia were independent risk factors for ischemic stroke recurrence (P<0.05). Logistic regression model had the best overall predictive power (AUC=0.810, 95% CI: 0.734 to 0.887) were higher than any of the independent predictors, such as plaque enhancement rate (AUC=0.714, 95% CI : 0.619 to 0.808) and kurtosis value (AUC=0.702, 95% CI: 0.607 to 0.796).Conclusions The kurtosis of ADC histogram, plaque area, plaque surface irregularity and plaque enhancement rate are independently correlated with the recurrence of anterior circulation ischemic stroke. The combination of ADC histogram and atherosclerotic plaque features have a high predictive value for the recurrence of anterior circulation ischemic stroke, and can provide relevant technical support for early clinical diagnosis and treatment.
[Keywords] vascular wall imaging；stroke；stroke recurrence；plaques；magnetic resonance imaging；apparent diffusion coefficient histogram

LUO Tong   GAO Yang*   WU Qiong   HE Jinlong   WANG Zehua  

Department of Radiology, Affiliated Hospital of Inner Mongolia Medical University, Hohhot010050, China

Corresponding author: GAO Y, E-mail: 1390903990@qq.com

Conflicts of interest   None.

Received  2024-07-26
Accepted  2024-12-10
DOI: 10.12015/issn.1674-8034.2024.12.014
Cite this article as: LUO T, GAO Y, WU Q, et al. Combined analysis based on the characteristics of intracranial atherosclerotic plaque and apparent diffusion coefficient histogram in predicting the recurrence of ischemic stroke[J]. Chin J Magn Reson Imaging, 2024, 15(12): 94-100. DOI:10.12015/issn.1674-8034.2024.12.014.

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