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Progress in cerebellar high-field and ultra-high-field magnetic resonance imaging and their applications in neurodegenerative diseases
HU Yuwei  YANG Xianfei  LI Congwei  OU Peiling  SHI Linfeng  LIU Chen 

Cite this article as: HU Y W, YANG X F, LI C W, et al. Progress in cerebellar high-field and ultra-high-field magnetic resonance imaging and their applications in neurodegenerative diseases[J]. Chin J Magn Reson Imaging, 2024, 15(12): 194-199, 211. DOI:10.12015/issn.1674-8034.2024.12.030.


[Abstract] Although the cerebellum of humans is quite small in volume, it plays a crucial role in motor control, balance maintenance, and cognitive functions. A variety of diseases, especially neurodegenerative diseases, involve the cerebellum during their progression, severely affecting the daily lives of patients. Therefore, studying the cerebellum in patients with neurodegenerative diseases (NDs) helps us understand their pathological mechanisms. Currently, the application of cerebellar high field magnetic resonance imaging (HF-MRI) in NDs has provided a wealth of imaging evidence for changes in cerebellar structure and function. Advanced ultra-high field magnetic resonance imaging (UHF-MRI) of the cerebellum allows us to further investigate the subtle structures and functional characteristics of the cerebellum, which holds broad prospects, but has not yet been widely applied in the study of NDs. This paper reviews the research progress of cerebellar HF-MRI and UHF-MRI, as well as their applications in NDs, and analyzes the advantages and challenges of cerebellar UHF-MRI. In the future, with the empowerment of cerebellar UHF-MRI, there is hope to identify neuroimaging biomarkers for the early and precise diagnosis of NDs from the cerebellar perspective.
[Keywords] cerebellum；neuroimaging；magnetic resonance imaging；ultra-high-field；brain structure；brain function；neurodegenerative diseases

HU Yuwei1, 2   YANG Xianfei1, 2   LI Congwei1, 2   OU Peiling1, 2   SHI Linfeng1, 2   LIU Chen1, 2*  

1 7 T Magnetic Resonance Imaging Translational Medical Center, Southwest Hospital, Army Medical University (Third Military Medical University), Chongqing400038, China

2 Department of Radiology, Southwest Hospital, Army Medical University (Third Military Medical University), Chongqing400038, China

Corresponding author: LIU C, E-mail: liuchen@tmmu.edc.cn

Conflicts of interest   None.

Received  2024-11-11
Accepted  2024-12-10
DOI: 10.12015/issn.1674-8034.2024.12.030
Cite this article as: HU Y W, YANG X F, LI C W, et al. Progress in cerebellar high-field and ultra-high-field magnetic resonance imaging and their applications in neurodegenerative diseases[J]. Chin J Magn Reson Imaging, 2024, 15(12): 194-199, 211. DOI:10.12015/issn.1674-8034.2024.12.030.

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