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Advances in brain MRI research on the correlation between obesity and cognitive decline
JIANG Chunrong  LIANG Lingyan  LIU Siqiu  LEI Miao  DENG Demao 

Cite this article as: JIANG C R, LIANG L Y, LIU S Q, et al. Advances in brain MRI research on the correlation between obesity and cognitive decline[J]. Chin J Magn Reson Imaging, 2025, 16(1): 170-174, 186. DOI:10.12015/issn.1674-8034.2025.01.027.


[Abstract] Obesity is a high risk factor for many diseases and an independent risk factor for death worldwide. The six key areas of cognitive function include complex attention, executive function, learning and memory, language, sensorimotor control, and social cognition. Studies at home and abroad have shown that obesity causes cognitive function decline, involving reward and motivation, sensorimotor, memory and cognitive control. Obesity can cause changes in brain structure and function, and then lead to cognitive function decline, but its mechanism is still unclear. MRI has been widely used in the study of neurological and psychiatric diseases. This review analyzes the effects of obesity on cognitive function and summarizes its potential mechanisms. This paper discusses and summarizes the brain MRI characteristics of obesity induced cognitive function decline, and reveals its correlation from the aspects of brain structure, function, metabolism, blood perfusion, etc., providing directions for the prevention and treatment of cognitive function decline in obese patients in the future.
[Keywords] obesity；cognitive function；magnetic resonance imaging；brain structure；brain function

JIANG Chunrong1, 2   LIANG Lingyan3   LIU Siqiu2   LEI Miao3   DENG Demao3*  

1 Graduate School of Guangxi University of Traditional Chinese Medicine, Nanning 530001, China

2 Department of Radiology, Guilin People's Hospital, Guilin 541000, China

3 Departmen of Radiology, Guangxi Zhuang Autonomous Region People's Hospital, Nanning 530021, China

Corresponding author: DENG D M, E-mail: demaodeng@163.com

Conflicts of interest   None.

Received  2024-10-11
Accepted  2025-01-10
DOI: 10.12015/issn.1674-8034.2025.01.027
Cite this article as: JIANG C R, LIANG L Y, LIU S Q, et al. Advances in brain MRI research on the correlation between obesity and cognitive decline[J]. Chin J Magn Reson Imaging, 2025, 16(1): 170-174, 186. DOI:10.12015/issn.1674-8034.2025.01.027.

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