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• Clinical Article •
Study on cerebral perfusion patterns in premature infants based on multi-delayed arterial spin labeling imaging
CHANG Miao  YUE Songhong  ZHANG Jing 

Cite this article as: CHANG M, YUE S H, ZHANG J. Study on cerebral perfusion patterns in premature infants based on multi-delayed arterial spin labeling imaging[J]. Chin J Magn Reson Imaging, 2025, 16(2): 1-6, 13. DOI:10.12015/issn.1674-8034.2025.02.001.


[Abstract] Objective To explore the changes of cerebral perfusion in premature infants with postmenstrual age (PMA) and the differences in cerebral perfusion between premature infants and normal full-term infants at term equivalent age (TEA) based on multidelay arterial spin labeling (MDASL).Materials and Methods Prospective data collection included 36 premature infants (gestational age < 37 weeks) and 18 normal full-term infants (gestational age ≥ 37 weeks), of which 18 premature infants with TEA were matched with 14 normal full-term infants in terms of PMA. All subjects underwent conventional MRI and MDASL scanning at 3.0 T GE premier. MDASL generated cerebral blood flow (CBF) images from 7 different postlabeling delays (PLD) through 8 acquisitions. The original images were processed by functool software to obtain arterial transit times (ATT) and transit time–corrected cerebral blood flow (tCBF) images. Linear regression was used to analyze the trend of tCBF changes with PMA in premature infants and normal full-term infants, and independent sample t-test was used to analyze the differences in tCBF and ATT between premature infants and full-term infants with TEA.Results The tCBF of all regions (except the pons) of normal full-term and premature infants increased with the increase of PMA (P < 0.05), among which the tCBF of the cerebellar hemisphere changed the most. The change of the cerebellar hemisphere in normal full-term infants (b = 0.829, P < 0.05) was greater than that in premature infants (b = 0.518, P < 0.05). Compared with normal full-term infants, the tCBF of premature infants with TEA was significantly higher in frontal white matter, temporal white matter, occipital white matter, frontal cortex, occipital cortex, lenticular nucleus, caudate nucleus, thalamus, hippocampus, cerebellar hemisphere and pons (P < 0.05). ATT in frontal cortex, thalamus and hippocampus of normal full-term infants was longer than that of premature TEA infants (P < 0.05).Conclusions MDASL can more accurately show the regional differences in cerebral perfusion between premature infants and normal full-term infants and the spatiotemporal trajectory of early brain development.
[Keywords] premature infants；cerebral blood flow；multidelay arterial spin labeling；magnetic resonance imaging；arterial transit times

CHANG Miao1, 2, 3   YUE Songhong1, 2, 3   ZHANG Jing1, 2, 3, 4*  

1 Department of Magnetic Resonance Imaging, the Second Hospital of Lanzhou University, Lanzhou 730030, China

2 The Second Clinical Medical School, Lanzhou University, Lanzhou 730030, China

3 Gansu Province Clinical Research Center for Functional and Molecular Imaging, Lanzhou 730030, China

4 Gansu Medical MRI Equipment Application Industry Technology Center, Lanzhou 730030, China

Corresponding author: ZHANG J, E-mail: ery_zhangjing@lzu.edu.cn

Conflicts of interest   None.

Received  2024-10-15
Accepted  2025-02-10
DOI: 10.12015/issn.1674-8034.2025.02.001
Cite this article as: CHANG M, YUE S H, ZHANG J. Study on cerebral perfusion patterns in premature infants based on multi-delayed arterial spin labeling imaging[J]. Chin J Magn Reson Imaging, 2025, 16(2): 1-6, 13. DOI:10.12015/issn.1674-8034.2025.02.001.

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