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• Clinical Article •
3D-pCASL in the developmental brain abnormalities of preterm infants born to hypertensive mothers during pregnancy
LI Sike  CHENG Meiying  ZHANG Lingjie  LU Yu  FENG Zhanqi  LIU Shipeng  FENG Liujuan  ZHOU Liang  ZHAO Xin 

Cite this article as: LI S K, CHENG M Y, ZHANG L J, et al. 3D-pCASL in the developmental brain abnormalities of preterm infants born to hypertensive mothers during pregnancy[J]. Chin J Magn Reson Imaging, 2025, 16(2): 7-13. DOI:10.12015/issn.1674-8034.2025.02.002.


[Abstract] Objective To quantitatively assess the cerebral blood flow (CBF) values of preterm infants delivered by hypertensive pregnant women during pregnancy using three-dimensional pseudo-continuous arterial spin labeling (3D-pCASL) imaging, and to investigate the potential association between CBF and inflammatory factor levels and Neonatal Behavioral Neurological Assessment (NBNA) scores in preterm infants.Materials and Methods The present study prospectively analyzed 80 preterm infants attending our hospital from July 2023 to June 2024, who were divided into a case group (40 cases) and a control group (40 cases) based on whether their mothers suffered from gestational hypertension or not. Conventional MRI and 3D-pCASL sequence scans were performed in both groups, and the CBF values of each brain region were compared between the two groups. The correlation between the CBF values and inflammatory factors and NBNA scores was analyzed.Results CBF values and inflammatory factor levels in several brain regions of preterm infants born to hypertensive mothers during pregnancy were significantly higher than those of the control group (P < 0.05), whereas NBNA scores were lower than those of the control group (P < 0.05). CBF values in the left frontal lobe, right temporal lobe, left parietal lobe, bilateral basal ganglia regions and thalamus showed some positive correlation with calcitoninogen ( r = 0.399, 0.469, 0.482, 0.535, 0.606, 0.692, 0.689, P < 0.05), and CBF values in the bilateral basal ganglia regions and thalamus showed a negative correlation with NBNA scores (r = -0.395, -0.429, -0.414, -0.438, P < 0.05).Conclusions The 3D-pCASL technique can non-invasively assess the CBF values of preterm infants with gestational hypertension in mothers, and elevated CBF values may be associated with poor prognosis of preterm infants with gestational hypertension in mothers, which will help in early diagnosis of brain dysplasia in their preterm infants and interventional treatment.
[Keywords] preterm infants；brain development；hypertension in pregnancy；arterial spin labeling；magnetic resonance imaging；inflammatory factor；Neonatal Behavioral Neurological Assessment scores

LI Sike1, 2, 3   CHENG Meiying1, 2, 3   ZHANG Lingjie1, 2, 3   LU Yu1, 2, 3   FENG Zhanqi1, 2, 3   LIU Shipeng1, 2, 3   FENG Liujuan1, 2, 3   ZHOU Liang1, 2, 3   ZHAO Xin1, 2, 3*  

1 Department of Medical Imaging, the Third Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China

2 Henan International Joint Laboratory of Neuroimaging, Zhengzhou 450052, China

3 Henan Provincial Key Laboratory of Pediatric Neuroimaging Medicine, Zhengzhou 450052, China

Corresponding author: ZHAO X, E-mail: zdsfyzx@zzu.edu.cn

Conflicts of interest   None.

Received  2024-11-14
Accepted  2025-01-10
DOI: 10.12015/issn.1674-8034.2025.02.002
Cite this article as: LI S K, CHENG M Y, ZHANG L J, et al. 3D-pCASL in the developmental brain abnormalities of preterm infants born to hypertensive mothers during pregnancy[J]. Chin J Magn Reson Imaging, 2025, 16(2): 7-13. DOI:10.12015/issn.1674-8034.2025.02.002.

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