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Advances in structural-functional connectivity coupling analysis for understanding post-stroke functional impairments
FANG Shengjie  LIU Zaixing  WU Yanan  HONG Wenjun  XU Rong 

Cite this article as: FANG S J, LIU Z X, WU Y N, et al. Advances in structural-functional connectivity coupling analysis for understanding post-stroke functional impairments[J]. Chin J Magn Reson Imaging, 2025, 16(2): 119-123, 129. DOI:10.12015/issn.1674-8034.2025.02.019.


[Abstract] As a prevalent neurological disorder, stroke can result in a variety of functional impairments, significantly impacting patients' quality of life. Structural connectivity (SC) and functional connectivity (FC), along with the SC-FC connectivity coupling analysis, have garnered considerable attention in the research of uncovering the neural mechanisms underlying post-stroke functional impairments. This review outlines the fundamental principles of SC-FC connectivity coupling analysis by summarizing the fundamentals of SC and FC and their mechanisms, and focus on the role of SC-FC connectivity coupling analysis applied to motor dysfunction, cognitive dysfunction, and mood disorders after stroke. By evaluating the coupling relationship between SC and FC, we can systematically analyze the potential neuroimaging features of the severity of dysfunction and rehabilitation potential. In turn, it can provide novel ideas for the personalized rehabilitation strategies for post-stroke patients.
[Keywords] stroke；functional impairment；magnetic resonance imaging；structural-functional connectivity coupling；neuroimaging；neurorehabilitation

FANG Shengjie1   LIU Zaixing2   WU Yanan2   HONG Wenjun2*   XU Rong1*  

1 Department of Rehabilitation Medicine, Nanjing Drum Tower Hospital Clinical College of Jiangsu University, Nanjing 210008, China

2 Department of Rehabilitation Medicine, Nanjing Drum Tower Hospital, the Affiliated Hospital of Nanjing University Medical School, Nanjing 210008, China

Corresponding author: HONG W J, E-mail: hwj_rehab@njglyy.com XU R, E-mail: xurong3973@163.com

Conflicts of interest   None.

Received  2024-10-30
Accepted  2025-02-10
DOI: 10.12015/issn.1674-8034.2025.02.019
Cite this article as: FANG S J, LIU Z X, WU Y N, et al. Advances in structural-functional connectivity coupling analysis for understanding post-stroke functional impairments[J]. Chin J Magn Reson Imaging, 2025, 16(2): 119-123, 129. DOI:10.12015/issn.1674-8034.2025.02.019.

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