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Research progress of blood-brain barrier evaluation methods based on arterial spin labeling in central nervous system diseases
LI Mengyao  ZHANG Hao  CAO Jibin 

Cite this article as: LI M Y, ZHANG H, CAO J B. Research progress of blood-brain barrier evaluation methods based on arterial spin labeling in central nervous system diseases[J]. Chin J Magn Reson Imaging, 2025, 16(2): 142-148. DOI:10.12015/issn.1674-8034.2025.02.023.


[Abstract] The blood-brain barrier (BBB) is a critical component of the neurovascular unit and is crucial for maintaining the stability of the central nervous system. Its dysfunction is associated with various neurological disorders. Arterial spin labeling (ASL) technology, a non-invasive magnetic resonance imaging (MRI) method, uses water protons as a natural endogenous tracer. By monitoring the exchange of ASL signals from microvessels to brain tissue, it assesses the functional status of the BBB. This article will discuss the application of three BBB assessment techniques based on ASL in Alzheimer's disease (AD), sickle cell disease (SCD), demyelinating diseases, cerebral small vessel disease (CSVD), and schizophrenia spectrum disorder (SSD), with the aim of providing important references for researchers to use these techniques to study the functional impairment of BBB in central nervous system diseases.
[Keywords] Alzheimer's disease；sickle cell disease；magnetic resonance imaging；arterial spin labeling；brain-blood barrier

LI Mengyao   ZHANG Hao   CAO Jibin*  

Department of Radiology, the First Hospital of China Medical University, Shenyang 110001, China

Corresponding author: CAO J B, E-mail: cmucao@163.com

Conflicts of interest   None.

Received  2024-11-12
Accepted  2025-02-10
DOI: 10.12015/issn.1674-8034.2025.02.023
Cite this article as: LI M Y, ZHANG H, CAO J B. Research progress of blood-brain barrier evaluation methods based on arterial spin labeling in central nervous system diseases[J]. Chin J Magn Reson Imaging, 2025, 16(2): 142-148. DOI:10.12015/issn.1674-8034.2025.02.023.

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