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Application of blood flow analysis method based on computational fluid dynamics and 4D Flow MRI in diagnosis and treatment of cardiovascular and cerebrovascular diseases
REN Lei  LIU Jihua  DING Jing  GUO Yu  XIA Shuang 

Cite this article as: REN L, LIU J H, DING J, et al. Application of blood flow analysis method based on computational fluid dynamics and 4D Flow MRI in diagnosis and treatment of cardiovascular and cerebrovascular diseases[J]. Chin J Magn Reson Imaging, 2025, 16(2): 172-178. DOI:10.12015/issn.1674-8034.2025.02.028.


[Abstract] In recent years, blood flow analysis of cardiovascular and cerebrovascular diseases has played an increasingly important role in clinic. Computational fluid dynamics (CFD) and 4D flow magnetic resonance imaging (4D Flow MRI) both can realize the visualization and quantification of blood flow in cardiovascular and cerebrovascular diseases. CFD is the calculation of blood flow by solving the hydrodynamic governing equations based on medical images. It has high spatial and temporal resolution, but depends on model setting and vessel wall boundary condition assumptions. 4D Flow MRI can directly measure true blood flow in the body, but the acquisition time is long and the resolution and accuracy are limited. Therefore, this paper aims to review the advantages and limitations of CFD and 4D Flow MRI, the combined application of the two methods, and the application progress in cardiovascular and cerebrovascular diseases, in order to provide clinicians with a beneficial tool for the diagnosis and treatment of vascular diseases.
[Keywords] cardiovascular and cerebrovascular diseases；computational fluid dynamics；4D flow magnetic resonance imaging；hemodynamics；magnetic resonance imaging

REN Lei1   LIU Jihua1   DING Jing2   GUO Yu2   XIA Shuang2*  

1 Department of Radiology, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin 300381, China

2 Department of Radiology, Tianjin First Central Hospital, Medical Imaging Institute of Tianjin, School of Medicine, Nankai University, Tianjin 300192, China

Corresponding author: XIA S, E-mail: xiashuang77@163.com

Conflicts of interest   None.

Received  2024-10-27
Accepted  2025-02-10
DOI: 10.12015/issn.1674-8034.2025.02.028
Cite this article as: REN L, LIU J H, DING J, et al. Application of blood flow analysis method based on computational fluid dynamics and 4D Flow MRI in diagnosis and treatment of cardiovascular and cerebrovascular diseases[J]. Chin J Magn Reson Imaging, 2025, 16(2): 172-178. DOI:10.12015/issn.1674-8034.2025.02.028.

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