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Research progress in the application of surface-based morphometry for brain structural MRI study in major depressive disorder
YANG Fan  XU Li  LIU Wei  YANG Jianzhong 

Cite this article as: YANG F, XU L, LIU W, et al. Research progress in the application of surface-based morphometry for brain structural MRI study in major depressive disorder[J]. Chin J Magn Reson Imaging, 2025, 16(3): 116-121, 132. DOI:10.12015/issn.1674-8034.2025.03.019.


[Abstract] Major depressive disorder (MDD) exhibits significant heterogeneity in its clinical symptoms, treatment responses, and pathological mechanisms, making it challenging for traditional neuroimaging techniques to untangle its complex brain structural characteristics. Surface-based morphometry (SBM), which quantifies indicators such as cortical thickness (CT), surface area (SA), and local gyrification index (LGI), offers a fresh perspective for elucidating the neurobiological heterogeneity of MDD. This article systematically reviews the critical advancements of SBM in MDD research, aiming to provide crucial imaging biomarkers for the precise classification of MDD.
[Keywords] depression；magnetic resonance imaging；structural magnetic resonance imaging；surface-based morphometry；surface area

YANG Fan1, 2   XU Li1   LIU Wei3   YANG Jianzhong1, 4*  

1 Department of Psychiatry, Second Affiliated Hospital of Kunming Medical University, Kunming 650000, China

2 Department of Clinical Medicine, Baoshan College of Traditional Chinese Medicine, Baoshan 678000, China

3 First Department of Mood Disorder, Second Affiliated Hospital of Xinxiang Medical College, Xinxiang 453002, China

4 Department of Psychiatry, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310000, China

Corresponding author: YANG J Z, E-mail: jzhyang2004@163.com

Conflicts of interest   None.

Received  2025-01-16
Accepted  2025-03-10
DOI: 10.12015/issn.1674-8034.2025.03.019
Cite this article as: YANG F, XU L, LIU W, et al. Research progress in the application of surface-based morphometry for brain structural MRI study in major depressive disorder[J]. Chin J Magn Reson Imaging, 2025, 16(3): 116-121, 132. DOI:10.12015/issn.1674-8034.2025.03.019.

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