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Advances in time-dependent diffusion MRI for tumor diagnosis and treatment response evaluation
LI Yanwan  CHEN Xiaoli 

Cite this article as: LI Y W, CHEN X L. Advances in time-dependent diffusion MRI for tumor diagnosis and treatment response evaluation[J]. Chin J Magn Reson Imaging, 2025, 16(3): 228-234. DOI:10.12015/issn.1674-8034.2025.03.039.


[Abstract] Time-dependent diffusion magnetic resonance imaging (TDD-MRI) is an emerging diffusion-weighted imaging technique, which can non-invasively quantify neoplastic cellular microstructural parameters such as cell diameter and cellularity, through established mathematical models fitting diffusion MRI data from using of oscillating gradient spin echo and pulsed gradient spin echo. TDD-MRI has been extensively investigated in oncology, including its application in differentiating benign from malignant tumors, evaluating tumor staging, and predicting tumor invasiveness, thereby demonstrating promising diagnostic performance. Consequently, this review aims to summarize the clinical research value and potential applications of TDD-MRI in tumors such as those of the head and neck, prostate, and breast, with the goal of providing insights for future research.
[Keywords] magnetic resonance imaging；diffusion-weighted imaging；time-dependent diffusion magnetic resonance imaging；oscillating gradient spin echo；tumor

LI Yanwan1, 2   CHEN Xiaoli2*  

1 School of Medicine University of Electronic Science and Technology of China, Chengdu 610051, China

2 Department of Radiology, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, Affiliated Cancer Hospital of University of Electronic Science and Technology of China, Chengdu 610041, China

Corresponding author: CHEN X L, E-mail: xiaolichen20@163.com

Conflicts of interest   None.

Received  2024-10-08
Accepted  2025-02-27
DOI: 10.12015/issn.1674-8034.2025.03.039
Cite this article as: LI Y W, CHEN X L. Advances in time-dependent diffusion MRI for tumor diagnosis and treatment response evaluation[J]. Chin J Magn Reson Imaging, 2025, 16(3): 228-234. DOI:10.12015/issn.1674-8034.2025.03.039.

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