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Progress on multimodal imaging technology in the brains of Crohn's disease patients with negative emotions
YU Li  YANG Ling  WU Xinyan  TANG Kaiqiang  ZHANG Lingqin  LI Kang 

Cite this article as: YU L, YANG L, WU X Y, et al. Progress on multimodal imaging technology in the brains of Crohn's disease patients with negative emotions[J]. Chin J Magn Reson Imaging, 2025, 16(4): 132-138. DOI:10.12015/issn.1674-8034.2025.04.021.


[Abstract] Patients with Crohn's disease (CD) often experience negative emotions such as anxiety and depression, which not only potentially compromise their mental health but also aggravate the disease progression and diminish their quality of life. Currently, clinical recognition of the negative emotions commonly associated with CD is limited. Standard anti-inflammatory treatments are ineffective in alleviating these symptoms, and the diagnostic methods available are subjective and restricted. Therefore, finding objective assessment methods to guide clinical diagnosis and treatment has become a critical issue. An increasing number of studies suggest that the development of negative emotions in CD patients is closely linked to structural and functional changes in specific brain regions. Currently, multimodal imaging techniques, such as structural magnetic resonance imaging, functional magnetic resonance imaging, and near-infrared spectroscopy, have been widely applied in the study of brain function and structural changes, demonstrating significant clinical value. This review will summarize the recent findings based on multimodal imaging techniques that have identified brain structural and functional changes associated with negative emotions such as anxiety and depression in CD patients. These findings provide neuroimaging-based evidence for future assessments and treatments of CD patients with comorbid negative emotions.
[Keywords] Crohn's disease；anxiety；depression；magnetic resonance imaging；structural magnetic resonance imaging；functional magnetic resonance imaging；near-infrared spectroscopy

YU Li1, 2, 3   YANG Ling2, 3   WU Xinyan2, 3, 4   TANG Kaiqiang2, 3   ZHANG Lingqin2, 3   LI Kang1, 2, 3*  

1 Chongqing Medical University, Chongqing 400016, China

2 Department of Radiology, Chongqing General Hospital, Chongqing University, Chongqing 401147, China

3 Department of Radiology, Chongqing General Hospital, Chongqing 401147, China

4 North Sichuan Medical Colledge, Nanchong 637100, China

Corresponding author: LI K, E-mail: lkrmyydoctor@126.com

Conflicts of interest   None.

Received  2025-01-09
Accepted  2025-04-10
DOI: 10.12015/issn.1674-8034.2025.04.021
Cite this article as: YU L, YANG L, WU X Y, et al. Progress on multimodal imaging technology in the brains of Crohn's disease patients with negative emotions[J]. Chin J Magn Reson Imaging, 2025, 16(4): 132-138. DOI:10.12015/issn.1674-8034.2025.04.021.

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