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Research progress on multimodal MRI of cognitive impairment in type 2 diabetes mellitus
ZHAO Kaidi  CAO Xinshan 

Cite this article as: ZHAO K D, CAO X S. Research progress on multimodal MRI of cognitive impairment in type 2 diabetes mellitus[J]. Chin J Magn Reson Imaging, 2025, 16(4): 145-150. DOI:10.12015/issn.1674-8034.2025.04.023.


[Abstract] Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder characterized by insulin resistance and dysfunction of β cells.In recent years, studies on brain damage in T2DM patients have gradually increased, such as voxel-based morphometry, brain structural networks, arterial spin labeling, quantitative magnetization transfer imaging, neurovascular coupling, etc, in multimodal MRI, as well as the monitoring and analysis of T2DM patients with cognitive impairment in terms of artificial intelligence and gut microbiota in multimodal MR. These are emerging methods for predicting and evaluating brain damage in T2DM patients. This article summarizes the latest application progress of multimodal MRI in brain structure, cerebral perfusion, iron deposition, neurovascular coupling, artificial intelligence, and gut microbiota in T2DM patients, with the aim of revealing the neurophysiological mechanism, making more accurate judgments on the disease progression of patients, formulating the best treatment strategies for patients, improving the prognosis of patients, and providing reference directions for future research.
[Keywords] type 2 diabetes；cognitive impairment；multimodal magnetic resonance imaging；magnetic resonance imaging；artificial intelligence；gut microbiota microorganisms

ZHAO Kaidi   CAO Xinshan*  

Department of Radiology, Affiliated Hospital of Binzhou Medical University, Binzhou 256600, China

Corresponding author: CAO X S, E-mail: byfycxs@126.com

Conflicts of interest   None.

Received  2025-03-07
Accepted  2025-04-10
DOI: 10.12015/issn.1674-8034.2025.04.023
Cite this article as: ZHAO K D, CAO X S. Research progress on multimodal MRI of cognitive impairment in type 2 diabetes mellitus[J]. Chin J Magn Reson Imaging, 2025, 16(4): 145-150. DOI:10.12015/issn.1674-8034.2025.04.023.

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