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• Clinical Article •
Preliminary exploration of the value of magnetic resonance arterial spin labeling imaging in the focal evaluation of febrile seizures
YANG Yang  ZHANG Shun  SHI Yan  QIN Yuanyuan  XU Sanqing 

Cite this article as: YANG Y, ZHANG S, SHI Y, et al. Preliminary exploration of the value of magnetic resonance arterial spin labeling imaging in the focal evaluation of febrile seizures[J]. Chin J Magn Reson Imaging, 2025, 16(5): 108-112, 119. DOI:10.12015/issn.1674-8034.2025.05.017.


[Abstract] Objective To explore the role of arterial spin labeling (ASL) imaging in the focal assessment of febrile seizures (FS).Materials and Methods The clinical and imaging data of FS children admitted to pediatric Neurology Department of Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology from January 2022 to July 2024 were retrospectively analyzed. Two senior radiologists performed blind reading of ASL cerebral blood flow images (ASL-CBF) and gave visual scores.Results A total of 24 eligible FS patients were included in this study, of which 3 patients showed no perfusion abnormality in ASL of the whole brain (1 point, 12.5%), and 21 patients (87.5%) showed abnormal perfusion, all with reduced perfusion, including 20 patients (83.3%) involved in the temporal region. Electroencephalogram (EEG) was performed in 22 of the 24 patients within 24 hours of FS onset, and there was no significant difference in ASL-CBF visual scores between normal and abnormal EEG groups (P = 0.698). According to the clinical symptomatology and EEG results, 6 of the 24 patients were classified as simple FS (25.0%), 14 as complex FS (58.3%), and 4 as persistent FS (16.7%); Among them, 4 patients with FS persistence showed bilateral asymmetry reduction (ASL-CBF score was 3 points). There were significant differences between the three groups in the time from FS onset to ASL collection, whether there was recurrence within 24 hours, and ASL-CBF visual score (P < 0.05). Post hoc analysis indicated that although there was no significant difference in ASL-CBF visual score between complex FS and FS persistence group (χ2 = 5.143, P = 0.162), the ASL-CBF visual score between simple FS and FS persistent state group showed significant difference (χ2 = 10.000, P = 0.019). Compared with simple FS, there were no significant differences in gender, age, time from FS onset to ASL collection, previous FS history, familial FS history, and EEG in patients with complex FS group (P > 0.05), except for whether there was recurrence within 24 hours (χ2 = 0.008, P = 0.008), which was basically consistent with clinical practice.Conclusions The underlying lesion of febrile seizures may be located in the temporal region, and the continuous state of FS showed asymmetric reduction of bilateral perfusion. ASL techniques are helpful in evaluating focal problems in FS, especially in those cases that had normal EEG and negative structural MRI.
[Keywords] febrile seizure；arterial spin labeling；magnetic resonance imaging；focal；temporal region

YANG Yang1   ZHANG Shun1   SHI Yan1   QIN Yuanyuan1*   XU Sanqing2  

1 Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430000, China

2 Department of Pediatric Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430000, China

Corresponding author: QIN Y Y, E-mail: qinyuanyuan-1021@163.com

Conflicts of interest   None.

Received  2024-12-31
Accepted  2025-05-10
DOI: 10.12015/issn.1674-8034.2025.05.017
Cite this article as: YANG Y, ZHANG S, SHI Y, et al. Preliminary exploration of the value of magnetic resonance arterial spin labeling imaging in the focal evaluation of febrile seizures[J]. Chin J Magn Reson Imaging, 2025, 16(5): 108-112, 119. DOI:10.12015/issn.1674-8034.2025.05.017.

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