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• Clinical Article •
Evaluation of the influence of left ventricular myocardial fibrosis on biventricular function in patients with coronary artery disease based on cardiac magnetic resonance feature tracking
NI Luying  ZHANG Qian  BAO Changjin  YU Mengmeng  ZHANG Di  JIANG Xingyue 

Cite this article as: NI L Y, ZHANG Q, BAO C J, et al. Evaluation of the influence of left ventricular myocardial fibrosis on biventricular function in patients with coronary artery disease based on cardiac magnetic resonance feature tracking[J]. Chin J Magn Reson Imaging, 2025, 16(5): 149-156. DOI:10.12015/issn.1674-8034.2025.05.023.


[Abstract] Objective To evaluate the influence of left ventricular myocardial fibrosis on left and right ventricular function in patients with coronary artery disease (CAD) based on cardiac magnetic resonance feature tracking (CMR-FT) technique, and to explore the biventricular interaction.Materials and Methods A total of 50 patients diagnosed with CAD and 32 healthy subjects from September 2023 to March 2025 were retrospectively analyzed. The left and right ventricle conventional cardiac function parameters, global strain parameters, including circumferential peak strain (PCS), radial peak strain (PRS) and longitudinal peak strain (PLS), and left ventricular late gadolinium enhancement percentage (%LGE) were measured after post-processing. According to the median value of %LGE, CAD patients were divided into %LGE ≥ 6% group and %LGE < 6% group. One-way analysis of variance, non-parametric test, Chi-square test and other statistical methods were used to compare the differences in clinical data and CMR parameters between the control group and different patient groups. Spearman or Pearson correlation coefficient was used to analyze the correlation between right ventricular function and left ventricular function as well as myocardial fibrosis, and multiple linear regression analysis was further performed.Results Compared with the %LGE < 6% group, left ventricle global PCS, PRS, PLS, ejection fraction (EF) and right ventricle global PLS were decreased, while left ventricular end-diastolic volume (EDV), end-diastolic volume index (EDVi), end-systolic volume (ESV), end-systolic volume index (ESVi), left ventricular mass (LVM), left ventricular mass index (LVMi) and %LGE were increased in the %LGE ≥ 6% group (all P < 0.05). Correlation analysis showed that right ventricle global PCS and PLS were positively correlated with left ventricular global PCS, PRS, PLS and EF, and negatively correlated with left ventricular EDVi, ESVi and %LGE (r = -0.762 to 0.731, all P < 0.05). Linear regression analysis showed that right ventricular global PCS was independently and positively correlated with left ventricular global PLS (β = 0.356, P = 0.011), and independently and negatively correlated with left ventricular ESVi (β = -0.362, P = 0.010); Right ventricular global PLS was independently and positively correlated with left ventricular global PRS (β = 0.291, P = 0.022), and independently and negatively correlated with %LGE (β = -0.344, P = 0.003).Conclusions Even though there are no significant changes in the conventional cardiac function parameters of the right ventricle, the left and right ventricular strains in CAD patients are impaired after left ventricular myocardial fibrosis. In addition, the right ventricular strain is independently and positively correlated with the left ventricular strain, and independently and negatively correlated with the degree of left ventricular myocardial fibrosis. CMR-FT can provide earlier and more accurate information for ventricular function impairment in CAD patients, and provide a new basis for early treatment.
[Keywords] feature tracking；strain；coronary artery disease；ventricular function；magnetic resonance imaging

NI Luying1, 2   ZHANG Qian1, 2   BAO Changjin1   YU Mengmeng1   ZHANG Di1   JIANG Xingyue1, 2*  

1 Department of Radiology, Binzhou Medical University Hospital, Binzhou 256603, China

2 School of Medical Imaging, Binzhou Medical University, Yantai 264003, China

Corresponding author: JIANG X Y, E-mail: xyjiang188@sina.com

Conflicts of interest   None.

Received  2025-01-26
Accepted  2025-05-09
DOI: 10.12015/issn.1674-8034.2025.05.023
Cite this article as: NI L Y, ZHANG Q, BAO C J, et al. Evaluation of the influence of left ventricular myocardial fibrosis on biventricular function in patients with coronary artery disease based on cardiac magnetic resonance feature tracking[J]. Chin J Magn Reson Imaging, 2025, 16(5): 149-156. DOI:10.12015/issn.1674-8034.2025.05.023.

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