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• Clinical Article •
Resting functional magnetic resonance imaging study of cerebral local consistency abnormality in patients with breast cancer after EC-T chemotherapy
FENG Wei  LIU Tonghui  LI Guoqiang  ZHANG Huawen  ZHANG Ming 

Cite this article as: FENG W, LIU T H, LI G Q, et al. Resting functional magnetic resonance imaging study of cerebral local consistency abnormality in patients with breast cancer after EC-T chemotherapy[J]. Chin J Magn Reson Imaging, 2025, 16(6): 21-26. DOI:10.12015/issn.1674-8034.2025.06.003.


[Abstract] Objective To explore the potential neural mechanism related to cognitive impairment in breast cancer patients treated with EC-T (E: epirubicin, C: cyclophosphamide, T: paclitaxel) chemotherapy using resting-state functional magnetic resonance imaging.Materials and Methods Twenty-nine breast cancer patients who underwent standard EC-T sequential chemotherapy were included in the study. Cognitive function assessments and MRI examinations were conducted before and after postoperative chemotherapy. We compared the longitudinal changes of cognitive function and regional homogeneity (ReHo) of related brain regions in breast cancer patients before and after chemotherapy and analyzed the correlation.Results Compared to before chemotherapy, breast cancer patients exhibited reduced scores in word learning, short-term delayed recall, long-term delayed recall, Color Block Connection Test - 1, Color Block Connection Test-2, and the number backward task (P < 0.05) after chemotherapy. Additionally, the ReHo values of the left anterior cingulate gyrus, left middle cingulate gyrus, right middle temporal gyrus, and left putamen decreased significantly (P < 0.001). Partial correlation analysis revealed that the difference in ReHo values of the left anterior cingulate gyrus before and after chemotherapy was positively correlated with the differences in word learning scores (r = 0.526, P < 0.05).Conclusions Chemotherapy can induce alterations in the local consistency of multiple brain regions in breast cancer patients, and can also result in cognitive impairment. The abnormal ReHo value of the left anterior cingulate gyrus can serve as a clinically meaningful imaging biomarker for monitoring cognitive function changes in breast cancer patients who have undergone chemotherapy.
[Keywords] breast cancer；chemotherapy；cognitive impairment；magnetic resonance imaging；regional homogeneity

FENG Wei1, 2   LIU Tonghui2   LI Guoqiang2   ZHANG Huawen2   ZHANG Ming1*  

1 Department of Medical Imaging, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710000, China

2 Department of Medical Imaging, NO.215 Hospital of Shaanxi Nuclear Industry, Xianyang 712000, China

Corresponding author: ZHANG M, E-mail: zmmri@163.com

Conflicts of interest   None.

Received  2025-01-16
Accepted  2025-06-10
DOI: 10.12015/issn.1674-8034.2025.06.003
Cite this article as: FENG W, LIU T H, LI G Q, et al. Resting functional magnetic resonance imaging study of cerebral local consistency abnormality in patients with breast cancer after EC-T chemotherapy[J]. Chin J Magn Reson Imaging, 2025, 16(6): 21-26. DOI:10.12015/issn.1674-8034.2025.06.003.

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