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• Clinical Article •
Changes in cerebral gray matter volume in patients with tremor-dominant Parkinson's disease: A voxel-based morphometry study
ZHANG Jiawen  HU Tao  ZHAO Beibei  LIN Bixia  CUI Xiaofeng  HUANG Rucheng  FENG Zehui  JIANG Yang 

Cite this article as: ZHANG J W, HU T, ZHAO B B, et al. Changes in cerebral gray matter volume in patients with tremor-dominant Parkinson's disease: A voxel-based morphometry study[J]. Chin J Magn Reson Imaging, 2025, 16(6): 42-47. DOI:10.12015/issn.1674-8034.2025.06.006.


[Abstract] Objective To apply voxel-based morphometry (VBM) to investigate the changes in gray matter volume (GMV) in the brains of patients with tremor-dominant Parkinson's disease (TD-PD).Materials and Methods Three-dimensional T1-weighted imaging scans were performed on 22 randomly selected TD-PD patients and 22 age- and gender-matched healthy control (HC). Voxel-based morphometry (VBM) analysis was conducted on the three-dimensional structural images using SPM12 to detect gray matter volume.Results Compared with the HC group, the gray matter volume of the right middle temporal gyrus (Temporal_Mid_L, MTG.R), the left superior orbitofrontal gyrus (Frontal_Mid_Orb_R, ORBsupmed.L), and the left calcarine cortex (Calcarine_L, CAL.L) were all reduced in the TD-PD group (FWE correction, cluster level P < 0.001). The gray matter volume of the above-mentioned brain regions was negatively correlated with the tremor score (disease severity) of PD patients (r = -0.491, -0.512, -0.522, all P < 0.05).Conclusions The tremor symptoms of PD patients are related to visual information processing disorders and the decline in spatial perception ability, which leads to the deterioration of autonomous motor functions. Moreover, as the severity of clinical tremor symptoms in PD patients increases, the degree of structural damage in the related brain regions also further worsens.
[Keywords] Parkinson's disease；tremor；magnetic resonance imaging；voxel-based morphometry；middle temporal gyrus；medial orbital frontal gyrus；pericalcarine cortex

ZHANG Jiawen1   HU Tao2   ZHAO Beibei1*   LIN Bixia2   CUI Xiaofeng3   HUANG Rucheng4   FENG Zehui5   JIANG Yang2  

1 Department of Radiology, Bao'an Traditional Chinese Medicine Hospital, Shenzhen 518100, China

2 Department of Rehabilitation, Bao'an Traditional Chinese Medicine Hospital, Shenzhen 518100, China

3 Department of Acupuncture and Moxibustion, Bao'an Traditional Chinese Medicine Hospital, Shenzhen 518100, China

4 Department of Encephalopathy (or Neurology), Bao'an Traditional Chinese Medicine Hospital, Shenzhen 518100, China

5 Department of Geriatrics, Bao'an Traditional Chinese Medicine Hospital, Shenzhen 518100, China

Corresponding author: ZHAO B B, E-mail: 67543816@qq.com

Conflicts of interest   None.

Received  2025-01-03
Accepted  2025-05-16
DOI: 10.12015/issn.1674-8034.2025.06.006
Cite this article as: ZHANG J W, HU T, ZHAO B B, et al. Changes in cerebral gray matter volume in patients with tremor-dominant Parkinson's disease: A voxel-based morphometry study[J]. Chin J Magn Reson Imaging, 2025, 16(6): 42-47. DOI:10.12015/issn.1674-8034.2025.06.006.

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