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• Clinical Article •
Study on the correlation between high resolution MRA of lenticularis artery and white matter injury of cerebral small vascular disease
WU Pengfei  WU Feiyun  SU Chunqiu  HOU Jingwen  LU Shanshan 

Cite this article as: WU P F, WU F Y, SU C Q, et al. Study on the correlation between high resolution MRA of lenticularis artery and white matter injury of cerebral small vascular disease[J]. Chin J Magn Reson Imaging, 2025, 16(6): 66-71, 77 DOI:10.12015/issn.1674-8034.2025.06.010.


[Abstract] Objective To explore the imaging effect of high-resolution compressed sensing (CS) TOF-MRA on lenticulostriate arteries (LSA), and the correlation between the morphological characteristics of LSA and white matter injury in cerebral small vessel disease (SVD).Materials and Methods Patients with SVD who underwent 3 T cranial MRI examination from April 2023 to February 2024 were prospectively included, including conventional MRI sequences and CS TOF-MRA sequences, and the SVD-related risk factors of the patients were collected, and SVD-related risk factors of the patients were collected. The patients were divided into four groups (F0, F1, F2, and F3 respectively) according to the Fazekas classification of white matter injury. The total number, total length, longest length and average length of LSAs in each group of patients were calculated based on the CS TOF-MRA sequence. Random block difference analysis and logistic regression analysis were used to analyze the relationship between each quantitative index of LSA, clinical index and the degree of white matter injury of the brain.Results A total of 72 patients with SVD were included, among which there were 15 cases in group F0, 25 cases in group F1, 15 cases in group F2, and 17 cases in group F3. There were statistically significant differences among the four groups of patients in terms of the total number and total length of LSAs (P < 0.05), while there were no statistically significant differences in the longest length and average length of LSAs (P > 0.05). Further pairwise comparisons showed that the total number of LSAs: F0 (6.40 ± 1.12) > F1 (5.24 ± 1.09) > F2 (4.46 ± 1.06) > F3 (3.76 ± 1.25), and the difference was statistically significant (P < 0.05). The total length of LSA: F0 (21.05 ± 4.20) cm > F1 (17.20 ± 5.69) cm > F2 (13.59 ± 4.22) cm > F3 (11.73 ± 5.38) cm, and the difference was statistically significant (P < 0.05). The longest length of LSA, F0 was higher than that of the other three groups, but there was no significant difference among the other three groups. The average length of LSA: F0 (3.29 ± 0.34) cm > F1 (3.22 ± 0.56) cm > F2 (2.99 ± 0.39) cm > F3 (2.98 ± 0.62) cm, and the difference was not statistically significant (P > 0.05). Logistic regression analysis showed the total number of LSAs (OR = 0.30, P < 0.001), total length of LSA (OR = 0.85, P = 0.048), age (OR = 1.09, P = 0.002), hypertension (OR = 3.36, P = 0.009) was independently correlated with the Fazekas classification.Conclusions High-resolution compressive sensing TOF-MRA technology can effectively evaluate the morphological characteristics of lentostriated arteries. Among them, the reduction in the total number and total length of LSAs is associated with the aggravation of white matter injury in patients with cerebral small vessel disease, while age and hypertension are independent risk factors. This technology provides a new imaging approach for the early diagnosis and risk assessment of cerebral small vessel diseases.
[Keywords] cerebral small vessel disease；white matter injury；lenticulostriate arteries；compressed sensing；magnetic resonance imaging；cerebral angiography

WU Pengfei   WU Feiyun   SU Chunqiu   HOU Jingwen   LU Shanshan*  

Department of Radiology, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China

Corresponding author: LU S S, E-mail: shanshanlu@njmu.edu.cn

Conflicts of interest   None.

Received  2025-03-12
Accepted  2025-06-10
DOI: 10.12015/issn.1674-8034.2025.06.010
Cite this article as: WU P F, WU F Y, SU C Q, et al. Study on the correlation between high resolution MRA of lenticularis artery and white matter injury of cerebral small vascular disease[J]. Chin J Magn Reson Imaging, 2025, 16(6): 66-71, 77 DOI:10.12015/issn.1674-8034.2025.06.010.

[1]
REN S X, YAO H B, ZHANG Y Y, et al. Study on the relationship between the characteristics of lenticulostriate artery and cerebral small vascular disease and the subtypes of infarct in lenticulostriate artery[J]. Chongqing Med, 2023, 52(16): 2453-2458. DOI: 10.3969/j.issn.1671-8348.2023.16.010.
[2]
TOZER D J, PFLANZ C P, MARKUS H S. Reproducibility of regional structural and functional MRI networks in cerebral small vessel disease compared to age matched and stroke-free controls[J/OL]. Cereb Circ Cogn Behav, 2023, 4: 100167 [2025-03-11]. https://pubmed.ncbi.nlm.nih.gov/37397269/. DOI: 10.1016/j.cccb.2023.100167.
[3]
WARDLAW J M, SMITH E E, BIESSELS G J, et al. Neuroimaging standards for research into small vessel disease and its contribution to ageing and neurodegeneration[J]. Lancet Neurol, 2013, 12(8): 822-838. DOI: 10.1016/S1474-4422(13)70124-8.
[4]
WARDLAW J M, SMITH C, DICHGANS M. Small vessel disease: mechanisms and clinical implications[J]. Lancet Neurol, 2019, 18(7): 684-696. DOI: 10.1016/S1474-4422(19)30079-1.
[5]
TAKASE K I, MURAI H, TASAKI R, et al. Initial MRI findings predict progressive lacunar infarction in the territory of the lenticulostriate artery[J]. Eur Neurol, 2011, 65(6): 355-360. DOI: 10.1159/000327980.
[6]
LIU X, ZHANG X L, LIU Q L. The effect of blood pressure variability on cognitive function in elderly patients with hypertension complicated with cerebral small vessal disease[J]. Chin J Clin Healthc, 2023, 26(5): 642-646. DOI: 10.3969/J.issn.1672-6790.2023.05.014.
[7]
ZHANG Z H, FAN Z Y, KONG Q L, et al. Visualization of the lenticulostriate arteries at 3T using black-blood T1-weighted intracranial vessel wall imaging: comparison with 7T TOF-MRA[J]. Eur Radiol, 2019, 29(3): 1452-1459. DOI: 10.1007/s00330-018-5701-y.
[8]
ZHANG X, CAO Y Z, MU X H, et al. Highly accelerated compressed sensing time-of-flight magnetic resonance angiography may be reliable for diagnosing head and neck arterial Steno-occlusive disease: a comparative study with digital subtraction angiography[J]. Eur Radiol, 2020, 30(6): 3059-3065. DOI: 10.1007/s00330-020-06682-3.
[9]
TAKAHASHI S, GOMYO M, TSUCHIYA K, et al. Anatomical information of the lenticulostriate arteries on high-resolution 3D-TOF MRA at 3 T: comparison with 3D-DSA[J]. Surg Radiol Anat, 2023, 45(10): 1287-1293. DOI: 10.1007/s00276-023-03232-6.
[10]
BYKANOV A E, PITSKHELAURI D I, BATALOV A I, et al. Sensitivity of three-dimensional time-of-flight 3.0 ​T magnetic resonance angiography in visualizing the number and course of lenticulostriate arteries in patients with insular gliomas[J/OL]. Brain Spine, 2021, 2: 100856 [2025-03-11]. https://pubmed.ncbi.nlm.nih.gov/36248136/. DOI: 10.1016/j.bas.2021.100856.
[11]
WEI N, JING J, ZHUO Y, et al. Morphological characteristics of lenticulostriate arteries in a large age-span population: Results from 7T TOF-MRA[J/OL]. Front Neurol, 2022, 13: 944863 [2025-03-11]. https://pubmed.ncbi.nlm.nih.gov/35937056/. DOI: 10.3389/fneur.2022.944863.
[12]
REN S J, WU W, SU C Q, et al. High-resolution compressed sensing time-of-flight MR angiography outperforms CT angiography for evaluating patients with Moyamoya disease after surgical revascularization[J/OL]. BMC Med Imaging, 2022, 22(1): 64 [2025-03-11]. https://pubmed.ncbi.nlm.nih.gov/35387607/. DOI: 10.1186/s12880-022-00790-w.
[13]
LI Q, SU C Q, WU P F, et al. Clinical value of high-resolution compressed sensing TOF-MRA in assessing Suzuki classification and the dilatation of hemorrhage related vascular in patients with moyamoya disease[J]. Chin J Magn Reson Imag, 2023, 14(4): 29-33. DOI: 10.12015/issn.1674-8034.2023.04.006.
[14]
WU P F, LU S S, LI Q, et al. Study on high resolution compressed sensing TOF-MRA imaging of lentiform artery[J]. J Nanjing Med Univ Nat Sci, 2023, 43(9): 1291-1294, 1332. DOI: 10.7655/NYDXBNS20230917.
[15]
SUZUKI T, NATORI T, SASAKI M, et al. Evaluating recanalization of relevant lenticulostriate arteries in acute ischemic stroke using high-resolution MRA at 7T[J]. Int J Stroke, 2021, 16(9): 1039-1046. DOI: 10.1177/1747493019897868.
[16]
LIANG J Y, LIU Y Y, XU X S, et al. Cerebral perforating artery disease: characteristics on high-resolution magnetic resonance imaging[J]. Clin Neuroradiol, 2019, 29(3): 533-541. DOI: 10.1007/s00062-018-0682-4.
[17]
HU W T, WANG Y, XIE Z H, et al. Functional segregation-integration preference configures the cognitive decline against cerebral small vessel disease: an MRI study[J/OL]. CNS Neurosci Ther, 2024, 30(12): e70162 [2025-03-11]. https://pubmed.ncbi.nlm.nih.gov/39690801/. DOI: 10.1111/cns.70162.
[18]
GUAN M, LIN J, HUANG S, et al. High-degree middle cerebral artery stenosis: can advanced 3D DSA-MRI fusion imaging better illustrate plaques and perforators?[J]. Clin Neuroradiol, 2021, 31(1): 51-59. DOI: 10.1007/s00062-020-00927-w.
[19]
HUANG F L, GUO Y R, CHEN R C, et al. Visualization of the Lenticulostriate artery with 3-dimensional time-of-flight magnetic resonance angiography combined with the compressed sensing technique using a 3-T magnetic resonance imaging system[J/OL]. Magn Reson Imaging, 2023, 102: 38-42 [2025-03-11]. https://pubmed.ncbi.nlm.nih.gov/36608910/. DOI: 10.1016/j.mri.2022.12.028.
[20]
LI Z X, SUN D B, LING C, et al. Quantitative modeling of lenticulostriate arteries on 7-T TOF-MRA for cerebral small vessel disease[J/OL]. Eur Radiol Exp, 2024, 8(1): 126 [2025-03-11]. https://pubmed.ncbi.nlm.nih.gov/39499373/. DOI: 10.1186/s41747-024-00512-7.
[21]
LI Q, LU S S, SUN T, et al. The applied research on the CS technique in intracranial MRA[J]. China Med Equip, 2020, 17(2): 66-70. DOI: 10.3969/J.ISSN.1672-8270.2020.02.018.
[22]
HIRANO Y, FUJIMA N, KAMEDA H, et al. High resolution TOF-MRA using compressed sensing-based deep learning image reconstruction for the visualization of lenticulostriate arteries: a preliminary study[J/OL]. Magn Reson Med Sci, 2024 [2025-03-11]. https://pubmed.ncbi.nlm.nih.gov/39034144/. DOI: 10.2463/mrms.mp.2024-0025.
[23]
DU Z W, ZHAO D L, MIAO Y Y, et al. Research progress of high-resolution magnetic resonance imaging in lentiform artery lesions[J]. J Clin Radiol, 2021, 40(2): 392-396. DOI: 10.13437/j.cnki.jcr.2021.02.042.
[24]
BAI X Y, FAN P P, LI Z Y, et al. Evaluating middle cerebral artery plaque characteristics and lenticulostriate artery morphology associated with subcortical infarctions at 7T MRI[J]. J Magn Reson Imag, 2024, 59(3): 1045-1055. DOI: 10.1002/jmri.28839.
[25]
OSUAFOR C N, RUA C, MACKINNON A D, et al. Visualisation of lenticulostriate arteries using contrast-enhanced time-of-flight magnetic resonance angiography at 7 Tesla[J/OL]. Sci Rep, 2022, 12(1): 20306 [2025-03-11]. https://pubmed.ncbi.nlm.nih.gov/36434036/. DOI: 10.1038/s41598-022-24832-z.
[26]
LEE C H, CHUNG J W, GUK H S, et al. Cerebral artery signal intensity gradient from Time-of-Flight Magnetic Resonance Angiography and clinical outcome in lenticulostriate infarction: a retrospective cohort study[J/OL]. Front Neurol, 2023, 14: 1220840 [2025-03-11]. https://pubmed.ncbi.nlm.nih.gov/37799283/. DOI: 10.3389/fneur.2023.1220840.
[27]
KANG C K, PARK C A, PARK C W, et al. Lenticulostriate arteries in chronic stroke patients visualised by 7 T magnetic resonance angiography[J]. Int J Stroke, 2010, 5(5): 374-380. DOI: 10.1111/j.1747-4949.2010.00464.x.
[28]
GROCHOWSKI C, KRUKOW P, JONAK K, et al. The assessment of lenticulostriate arteries originating from middle cerebral artery using ultra high-field magnetic resonance time-of-flight angiography[J/OL]. J Clin Neurosci, 2019, 68: 262-265 [2025-03-11]. https://pubmed.ncbi.nlm.nih.gov/31331750/. DOI: 10.1016/j.jocn.2019.07.003.
[29]
XIE W W, WANG C, LIU S, et al. Visualization of lenticulostriate artery by intracranial dark-blood vessel wall imaging and its relationships with lacunar infarction in basal Ganglia: a retrospective study[J]. Eur Radiol, 2021, 31(8): 5629-5639. DOI: 10.1007/s00330-020-07642-7.
[30]
LIANG H Q, GU Y W, ZHANG H P, et al. 7-Tesla magnetic resonance imaging for monitoring microstructural changes in the lenticulostriate artery-neural complex in patients with hypertension[J]. Quant Imaging Med Surg, 2024, 14(12): 8308-8319. DOI: 10.21037/qims-24-869.
[31]
Expert Consensus on Diagnosis and Treatment of small cerebral vascular Diseases in China, et al. Chinese consensus on diagnosis and therapy of cerebral small vessel disease 2021[J]. Chin J Stroke, 2021, 16(7): 716-726. DOI: 10.3969/j.issn.1673-5765.2021.07.013.
[32]
CHENG Z Y, YANG L F, LIANG C H, et al. Advancing cerebral small vessel disease diagnosis: Integrating quantitative susceptibility mapping with MRI-based radiomics[J/OL]. Hum Brain Mapp, 2024, 45(13): e70022 [2025-03-11]. https://pubmed.ncbi.nlm.nih.gov/39254181/. DOI: 10.1002/hbm.70022.
[33]
ZHANG Y K, CHANG P P, GAO B B, et al. 3.0T three-dimensional high resolution vessel wall MRI for displaying lenticulostriate artery changes of cerebral small vessel disease[J]. Chin J Med Imag Technol, 2023, 39(5): 665-669. DOI: 10.13929/j.issn.1003-3289.2023.05.005.
[34]
TANG J N, ZHAO T R, JOE E B, et al. Association of pulsatility of lenticulostriate arteries with cognitive decline in elderly adults: a 7T dual-VENC PC-MRI study[J/OL]. Alzheimers Dement, 2024, 20(S2): e093252 [2025-03-11]. https://alz-journals.onlinelibrary.wiley.com/doi/10.1002/alz.093252. DOI: 10.1002/alz.093252.
[35]
MA S J, SARABI M S, YAN L R, et al. Characterization of lenticulostriate arteries with high resolution black-blood T1-weighted turbo spin echo with variable flip angles at 3 and 7 Tesla[J/OL]. Neuroimage, 2019, 199: 184-193 [2025-03-11]. https://pubmed.ncbi.nlm.nih.gov/31158475/. DOI: 10.1016/j.neuroimage.2019.05.065.
[36]
ZHENG D L, LI X M, FU Y P. Risk factors of acute cerebral infarction in patients with primary hypertension[J]. Ir J Med Sci 1971, 2023, 192(5): 2441-2445. DOI: 10.1007/s11845-022-03206-4.
[37]
LIU Y, LI S, TIAN X, et al. More severe cerebral small vessel disease associated with poor leptomeningeal collaterals in symptomatic intracranial atherosclerotic stenosis[J]. J Cereb Blood Flow Metab, 2025, 45(4): 655-663. DOI: 10.1177/0271678x241292537.
[38]
CHEN Y C, LI Y H, LU J, et al. Correlation between the reduction in lenticulostriate arteries caused by hypertension and changes in brain metabolism detected with MRI[J]. AJR Am J Roentgenol, 2016, 206(2): 395-400. DOI: 10.2214/AJR.15.14514.
[39]
ZHANG Z, KONG Q L, ZHANG Y K, et al. Improved characterization of lenticulostriate arteries using compressed sensing time-of-flight at 7T[J]. Eur Radiol, 2023, 33(10): 6939-6947. DOI: 10.1007/s00330-023-09629-6.

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