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• Clinical Article •
MRI-based study of gray matter morphological in children with bilateral spastic cerebral palsy
LIU Junwei  XU Gaoqiang  HE Yulun  LIU Heng  ZHANG Tijiang 

Cite this article as: LIU J W, XU G Q, HE Y L, et al. MRI-based study of gray matter morphological in children with bilateral spastic cerebral palsy[J]. Chin J Magn Reson Imaging, 2025, 16(6): 72-77. DOI:10.12015/issn.1674-8034.2025.06.011.


[Abstract] Objective To investigate the cortical morphological changes in children with bilateral spastic cerebral palsy (BSCP) associated with periventricular white matter lesions (PWML).Materials and Methods Data of 19 clinically diagnosed BSCP children and 20 control children from April 2019 to September 2021 were collected. All children underwent high-resolution 3D-T1WI structural imaging and gross motor function assessments was performed for the BSCP group. Voxel-based morphometric analysis (VBM) was used to detect differences in gray matter volume between the two groups. Surface-based morphometric analysis (SBM) was employed to assess cortical thickness changes between groups. Group differences in gray matter volume and cortical thickness were analyzed using two-sample t-tests, with multiple comparison corrections applied using the FDR method.Results Compared to the control group, the BSCP group showed reduced gray matter volume in the bilateral medial prefrontal cortex, premotor area, middle cingulate cortex, caudate nucleus, thalamus, and right dorsolateral prefrontal cortex (P < 0.05, FDR corrected), with a negative correlation between the average gray matter volume of the right medial prefrontal cortex and gross motor function classification system (GMFCS) levels (r = -0.623, P = 0.004). Cortical thickness was reduced in the bilateral medial prefrontal cortex, left anterior cingulate cortex, precuneus, inferior parietal lobule, and right middle cingulate cortex (P < 0.05, FDR corrected).Conclusions Children with BSCP associated with PWML exhibit abnormalities in gray matter volume and cortical thickness across multiple brain regions, reflecting changes in the microstructure of their brains, providing imaging evidence for potential pathophysiological mechanisms.
[Keywords] cerebral palsy；magnetic resonance imaging；voxel-based morphometric analysis；surface-based morphometric analysis；grey matter

LIU Junwei   XU Gaoqiang   HE Yulun   LIU Heng   ZHANG Tijiang*  

Department of Radiology, the Affiliated Hospital of Zunyi Medical University, Guizhou Medical Image Center, Zunyi 563000, China

Corresponding author: ZHANG T J, E-mail: tijzhang@163.com

Conflicts of interest   None.

Received  2024-11-06
Accepted  2025-06-05
DOI: 10.12015/issn.1674-8034.2025.06.011
Cite this article as: LIU J W, XU G Q, HE Y L, et al. MRI-based study of gray matter morphological in children with bilateral spastic cerebral palsy[J]. Chin J Magn Reson Imaging, 2025, 16(6): 72-77. DOI:10.12015/issn.1674-8034.2025.06.011.

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