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Research progress of functional MRI radiomics in Parkinson's disease
CUI Jiaqi  YU Qian'e  ZHANG Tijiang 

Cite this article as: CUI J Q, YU Q E, ZHANG T J. Research progress of functional MRI radiomics in Parkinson's disease[J]. Chin J Magn Reson Imaging, 2025, 16(6): 132-138. DOI:10.12015/issn.1674-8034.2025.06.020.


[Abstract] Parkinson's disease (PD) constitutes an age-related neurodegenerative disorder characterized by progressive deterioration, imposing substantial burdens on patients and their families while generating significant strain on healthcare resources. Early diagnosis and therapeutic intervention are crucial for mitigating disease progression; however, current diagnostic approaches demonstrate superior sensitivity for motor symptoms compared to non-motor manifestations, and the underlying neuropathophysiological mechanisms remain incompletely elucidated. Biomarker discovery represents a pivotal research priority. Whereas conventional imaging diagnostics rely on visual assessment of low-dimensional data, radiomics employs high-throughput computational methodologies to extract high-dimensional features from medical images, thereby enriching PD research with quantifiable markers. This technique has been extensively implemented across multiple domains, including presymptomatic detection, subtype classification, progression monitoring, and outcome prognostication. However, existing reviews have relatively few studies on radiomics based on functional magnetic resonance imaging (fMRI) in PD, lacking systematic and comprehensive sorting and in-depth analysis. This article aims to provide a new perspective for the diagnosis and treatment research of PD in the future, systematically sort out the research progress of fMRI radiomics in PD, analyze the current challenges and propose the future development directions, expecting to promote the further development of this field.
[Keywords] Parkinson's disease；neurodegenerative disease；magnetic resonance imaging；functional magnetic resonance imaging；radiomics

CUI Jiaqi   YU Qian'e   ZHANG Tijiang*  

Department of Radiology, Affiliated Hospital of Zunyi Medical University, Medical Imaging Center of Guizhou Province, Zunyi 563003, China

Corresponding author: ZHANG T J, E-mail: tijzhang@163.com

Conflicts of interest   None.

Received  2025-03-08
Accepted  2025-06-10
DOI: 10.12015/issn.1674-8034.2025.06.020
Cite this article as: CUI J Q, YU Q E, ZHANG T J. Research progress of functional MRI radiomics in Parkinson's disease[J]. Chin J Magn Reson Imaging, 2025, 16(6): 132-138. DOI:10.12015/issn.1674-8034.2025.06.020.

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