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Advances in MRI studies of changes in choroid plexus structure and function in neurodegenerative diseases in MRI research
LI Yuxin  ZHAO Yang  GONG Tao  CHEN Yufan  ZHUO Mengyuan  WANG Guangbin 

Cite this article as: LI Y X, ZHAO Y, GONG T, et al. Advances in MRI studies of changes in choroid plexus structure and function in neurodegenerative diseases in MRI research[J]. Chin J Magn Reson Imaging, 2025, 16(6): 139-143, 149. DOI:10.12015/issn.1674-8034.2025.06.021.


[Abstract] With the accelerating global trend of population aging, the incidence of neurodegenerative diseases such as Alzheimer's disease (AD) and Parkinson's disease (PD) is rising significantly, posing a major public health challenge due to their complex pathogenesis and the current lack of effective early diagnostic tools, which creates substantial obstacles in clinical management. The choroid plexus (ChP), serving as the primary site of cerebrospinal fluid production and a critical component of the blood-cerebrospinal fluid barrier, exhibits structural and functional alterations closely associated with brain microenvironmental imbalance and glymphatic system dysfunction. Extensive laboratory and clinical evidence demonstrates significant changes in the ChP within aging populations and individuals afflicted by neurodegenerative disorders. Consequently, precise assessment of the ChP is critically important for elucidating pathological mechanisms, enabling early diagnosis, and guiding personalized therapeutic strategies in neurodegenerative diseases. However, current understanding of the ChP's role in neurological diseases remains incomplete, and comprehensive systematic reviews are notably lacking. This article systematically reviews the research progress in utilizing MRI technology to evaluate structural and functional changes of the ChP in neurodegenerative diseases, analyzes prevailing challenges in technical application and mechanistic exploration, and proposes future research directions, aiming to provide valuable insights for improving the diagnosis and treatment of these conditions. We contend that future efforts should focus on advancing novel MRI techniques specifically for ChP imaging, elucidating the causal relationships underlying ChP alterations in the pathogenesis of neurological diseases, and exploring the potential of ChP-derived metrics as biomarkers to pave the way for enhanced early diagnosis, disease monitoring, and personalized therapeutic interventions in neurodegenerative disorders.
[Keywords] choroid plexus；magnetic resonance imaging；neurodegenerative diseases；Alzheimer's disease；Parkinson's disease

LI Yuxin1   ZHAO Yang1   GONG Tao1   CHEN Yufan1   ZHUO Mengyuan2   WANG Guangbin1*  

1 Department of Radiology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan 250021, China

2 Shandong University, Jinan 250012, China

Corresponding author: WANG G B, E-mail: cjr.wangguangbin@vip.163.com

Conflicts of interest   None.

Received  2024-12-12
Accepted  2025-06-06
DOI: 10.12015/issn.1674-8034.2025.06.021
Cite this article as: LI Y X, ZHAO Y, GONG T, et al. Advances in MRI studies of changes in choroid plexus structure and function in neurodegenerative diseases in MRI research[J]. Chin J Magn Reson Imaging, 2025, 16(6): 139-143, 149. DOI:10.12015/issn.1674-8034.2025.06.021.

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