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Advances in MRI research of thalamic structural and functional alterations in insomnia disorder
CUI Jiahe  YUE Hongyu  XIE Fangfang  XIE Chaoqun  MA Jianwen  HAN Haotian  YAO Fei 

Cite this article as: CUI J H, YUE H Y, XIE F F, et al. Advances in MRI research of thalamic structural and functional alterations in insomnia disorder[J]. Chin J Magn Reson Imaging, 2025, 16(6): 144-149. DOI:10.12015/issn.1674-8034.2025.06.022.


[Abstract] Insomnia disorder (ID) represents a critical public health issue requiring urgent resolution, characterized by core clinical features including dissatisfaction with sleep duration or quality, and difficulties in sleep initiation or maintenance. The thalamus, a key brain region regulating sleep-wake cycles, plays a crucial role in both wakefulness and sleep. Prior studies have shown structural, functional, and metabolic alterations in the thalamus of individuals with ID. However, these studies often focus on single changes within the ID thalamus, lacking a holistic perspective and a unified understanding of systemic alterations. This review aims to summarize research progress on ID-related thalamic changes, to broaden understanding of thalamic alterations in ID patients and to provide new avenues for future research.
[Keywords] insomnia disorder；thalamus；magnetic resonance imaging；structural magnetic resonance imaging；resting state functional magnetic resonance imaging；arterial spin labeling

CUI Jiahe1   YUE Hongyu1   XIE Fangfang2   XIE Chaoqun2   MA Jianwen2   HAN Haotian2   YAO Fei1, 2, 3*  

1 Department of Tuina, Shanghai municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200071, China

2 School of Acupuncture-Moxibustion and Tuina, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China

3 Department of Tuina, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China

Corresponding author: YAO F, E-mail: doctoryaofei@126.com

Conflicts of interest   None.

Received  2025-03-11
Accepted  2025-06-10
DOI: 10.12015/issn.1674-8034.2025.06.022
Cite this article as: CUI J H, YUE H Y, XIE F F, et al. Advances in MRI research of thalamic structural and functional alterations in insomnia disorder[J]. Chin J Magn Reson Imaging, 2025, 16(6): 144-149. DOI:10.12015/issn.1674-8034.2025.06.022.

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