Share:
Share this content in WeChat
X
Case Report
Imaging and pathological analysis of a high-grade astrocytoma with piloid features: A case report and literature review
LEI Yan  NIU Fengnan  ZHANG Xin  ZHANG Bing 

Cite this article as: LEI Y, NIU F N, ZHANG X, et al. Imaging and pathological analysis of a high-grade astrocytoma with piloid features: A case report and literature review[J]. Chin J Magn Reson Imaging, 2025, 16(7): 81-84, 90. DOI:10.12015/issn.1674-8034.2025.07.012.


[Keywords] high-grade astrocytoma with piloid features;magnetic resonance imaging;pathological diagnosis;deoxyribo-nucleic acid methylation

LEI Yan1, 2, 3   NIU Fengnan1, 2, 3   ZHANG Xin1, 2, 3   ZHANG Bing1, 2, 3*  

1 Department of Medical Imaging, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing 210008, China

2 Institute of Medical Imaging and Artificial Intelligence, Nanjing University, Nanjing 210008, China

3 Medical Imaging Center, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing 210008,China

Corresponding author: ZHANG B, E-mail: zhangbing_nanjing@nju.edu.cn

Conflicts of interest   None.

Received  2025-04-27
Accepted  2025-07-07
DOI: 10.12015/issn.1674-8034.2025.07.012
Cite this article as: LEI Y, NIU F N, ZHANG X, et al. Imaging and pathological analysis of a high-grade astrocytoma with piloid features: A case report and literature review[J]. Chin J Magn Reson Imaging, 2025, 16(7): 81-84, 90. DOI:10.12015/issn.1674-8034.2025.07.012.

[1]
REINHARDT A, STICHEL D, SCHRIMPF D, et al. Anaplastic astrocytoma with piloid features, a novel molecular class of IDH wildtype glioma with recurrent MAPK pathway, CDKN2A/B and ATRX alterations[J]. Acta Neuropathol, 2018, 136(2): 273-291. DOI: 10.1007/s00401-018-1837-8.
[2]
LOUIS D N, PERRY A, WESSELING P, et al. The 2021 WHO Classification of Tumors of the Central Nervous System: a summary[J]. Neuro Oncol, 2021, 23(8): 1231-1251. DOI: 10.1093/neuonc/noab106.
[3]
BICZOK A, STRUBING F L, EDER J M, et al. Molecular diagnostics helps to identify distinct subgroups of spinal astrocytomas[J/OL]. Acta Neuropathol Commun, 2021, 9(1): 119 [2025-04-27]. https://doi.org/10.1186/s40478-021-01222-6. DOI: 10.1186/s40478-021-01222-6.
[4]
CIELO B. QLTI-01. High-grade astrocytoma with piloid features response to treatment with carboplatin and vincristine[J]. Neuro Oncol, 2023, 25(Supplement_5): v244-v245. DOI: 10.1093/neuonc/noad179.0939.
[5]
EJAZ Z H, MEMON A H, ANWAR S S M, et al. High-grade astrocytoma with piloid features: A case report and review of literature[J/OL]. Surg Neurol Int, 2025, 16: 66 [2025-04-27]. https://pubmed.ncbi.nlm.nih.gov/40041064/. DOI: 10.25259/sni_889_2024.
[6]
NIWA H, KATO T, HASEGAWA T, et al. Recurrent symptomatic intracranial hemorrhage in high-grade astrocytoma with piloid features: illustrative case[J/OL]. J Neurosurg Case Lessons, 2024, 8(15): CASE24395 [2025-04-27]. https://pubmed.ncbi.nlm.nih.gov/39378520/. DOI: 10.3171/CASE24395.
[7]
BENDER K, PEREZ E, CHIRICA M, et al. High-grade astrocytoma with piloid features (HGAP): the Charite experience with a new central nervous system tumor entity[J]. J Neuro-Oncol, 2021, 153(1): 109-120. DOI: 10.1007/s11060-021-03749-z.
[8]
GOETHE E A, SRINIVASAN S, KUMAR S, et al. High-grade astrocytoma with piloid features: a single-institution case series and literature review[J/OL]. Acta Neuropathol Commun, 2025, 13(1): 82 [2025-04-27]. https://doi.org/10.1186/s40478-025-01987-0. DOI: 10.1186/s40478-025-01987-0.
[9]
LIU K, HUANG Z, ZHAO L, et al. Significant Response to Palbociclib Plus Lenvatinib as Second-line Treatment for CDKN2A/2B Deletion Intrahepatic Cholangiocarcinoma: A Case Report[J]. J Clin Transl Hepatol, 2025, 13(2): 169-172. DOI: 10.14218/JCTH.2024.00404.
[10]
CIMINO P J, KETCHUM C, TURAKULOV R, et al. Expanded analysis of high-grade astrocytoma with piloid features identifies an epigenetically and clinically distinct subtype associated with neurofibromatosis type 1[J]. Acta Neuropathol, 2023, 145(1): 71-82. DOI: 10.1007/s00401-022-02513-5.
[11]
FORTIN ENSIGN S P, JENKINS R B, GIANNINI C, et al. Translational significance of CDKN2A/B homozygous deletion in isocitrate dehydrogenase-mutant astrocytoma[J]. Neuro Oncol, 2023, 25(1): 28-36. DOI: 10.1093/neuonc/noac205.
[12]
DINCER A, KIM M, HUSEYINOGLU Z, et al. Reclassification of pineal tumor as high-grade astrocytoma with piloid features through methylation profiling: illustrative case[J/OL]. J Neurosurg Case Lessons, 2025, 9(18): CASE24778 [2025-04-27]. https://doi.org/10.3171/CASE24778. DOI: 10.3171/CASE24778.
[13]
SONI N, AGARWAL A, AJMERA P, et al. High-Grade Astrocytoma with Piloid Features: A Dual Institutional Review of Imaging Findings of a Novel Entity[J]. Am J Neuroradiol, 2024, 45(4): 468-474. DOI: 10.3174/ajnr.A8166.
[14]
MUGHAL A U R, KHAN M N. High-grade astrocytoma with piloid features: MRI findings associated with a novel entity[J]. Radiology case reports, 2024, 19(12): 6436-6439. DOI: 10.1016/j.radcr.2024.09.097
[15]
ZHU Z Y, HAN X W, YE M P, et al. Progress of MRI in differentiating treatment-related changes and recurrence of glioblastoma[J]. Chin J Magn Reson Imaging, 2023, 14(4): 147-153. DOI: 10.12015/issn.1674-8034.2023.04.026.

PREV Clinical evaluation of a transportable MRI detection array for multi-site human imaging applications
NEXT A case of anti-NMDAR encephalitis with bilateral basal ganglia symmetry lesions
  



Tel & Fax: +8610-67113815    E-mail: editor@cjmri.cn