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Research progress of dynamic functional connectivity in adolescent depression
CAI Wenyu  HE Changjing  TIAN Yu  LIU Songjiang 

Cite this article as: CAI W Y, HE C J, TIAN Y, et al. Research progress of dynamic functional connectivity in adolescent depression[J]. Chin J Magn Reson Imaging, 2025, 16(7): 97-101. DOI:10.12015/issn.1674-8034.2025.07.016.


[Abstract] Depression is a severe mental disorder that poses a significant threat to the physical and mental health of adolescents. Its underlying neuropathological mechanisms, particularly the core neural circuits associated with abnormalities in dynamic functional networks, remain incompletely elucidated. Dynamic functional connectivity (dFC) can capture the dynamic characteristics of brain functional networks over time, which is crucial for a deeper understanding of the occurrence and development mechanisms of adolescent depression. However, the application of dFC analysis methods in adolescent depression has not yet been systematically reviewed and summarized. This article reviews the important results, limitations, and development prospects of dFC analysis methods such as sliding window correlation (SWC), co-activation patterns (CAPs), dynamic independent component analysis (dyn-ICA), and dynamic causal modeling (DCM) in adolescent depression research from the perspectives of technical principles and clinical applications. It provides a new perspective for further understanding the neuropathological mechanisms of adolescent depression, exploring new imaging markers, and potential clinical treatment plans. This article suggests that analyzing the dynamic features of adolescent brain networks can provide new ideas for developing precise diagnosis and treatment strategies for adolescent depression.
[Keywords] depression；adolescent；magnetic resonance imaging；functional magnetic resonance imaging；dynamic functional connectivity；brain network

CAI Wenyu1   HE Changjing1   TIAN Yu2   LIU Songjiang1*  

1 Department of Radiology, Affiliated Hospital of Zunyi Medical University, Zunyi 563000, China

2 Department of Radiology, Chongqing Tongliang District People's Hospital, Chongqing 402560, China

Corresponding author: LIU S J, E-mail: haitliu0817@163.com

Conflicts of interest   None.

Received  2025-04-21
Accepted  2025-07-07
DOI: 10.12015/issn.1674-8034.2025.07.016
Cite this article as: CAI W Y, HE C J, TIAN Y, et al. Research progress of dynamic functional connectivity in adolescent depression[J]. Chin J Magn Reson Imaging, 2025, 16(7): 97-101. DOI:10.12015/issn.1674-8034.2025.07.016.

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